Operating in an 'expanded field'

Not availabl

Hybrid vigour and the art of mixing

A large number of current projects-particularly speculative onesrequire multiple functions to be housed together. The concentration of various activities into one structure, as Steven Holl has written, places pressures on the architecture and has a capacity to' .. . distend and warp a pure building type ' 1 ' The current boom in high density buildings has in part been fed by exploding economies, astronomical rises in land value and the rise of emerging economic zones, in particular China, over the last twenty years. The increasing tendency among designers in dealing with this problem has seen the re-emergence of the hybrid building, in preference to a 'sum of all parts' mixed use solution, a level of concentration and hybridisation is increasingly understood as a way of activating the building, its individual uses and the surrounding urban fabric

The effects of cyclophosphamide on pulmonary thrombopoiesis in rats

Cyclophosphamide (CP), an antineoplastic and immunosuppresive agent, even when administered in large doses, slightly affects the quantity of blood platelets. The aim of the present study was to analyse the effect of single intraperitoneal administration of CP (150mg/kg b.w.) on the quantitative changes in platelets obtained from the left and right ventricle of the heart, as well as to evaluate the occurrence of megakaryocytes in lung tissue depending on the period of time that passed from CP administration.In control subgroups, fewer platelets were found in the blood collected from the RV compared with the left ventricle at all time intervals. After 1 and 3 days following i.p, administration of CP, a decrease was observed in the number of platelets both in the blood from the right ventricle and left ventricle when compared with control. However, after 14 days, the number of platelets in the blood from the left ventricle was higher, compared with the left ventricle and right ventricle of control animals, and significantly higher (p<0.001747), compared with their number obtained from the right ventricle of CP-receiving animals.Simultaneous ultrastructural examinations with transmission electron microscopy revealed the increased number of platelets in the lung vascular bed of CPreceiving rats at all time intervals. However, megakaryocytes were found 7 and 14 days after administration of CP. The findings clearly indicate that the lungs could be a major place of thrombopoiesis following therapy with a single large dose of CP

How public is your private? Background to Melbourne's e(i)xample

Not availabl

The effects of cyclophosphamide on pulmonary thrombopoiesis in rats

Cyclophosphamide (CP), an antineoplastic and immunosuppresive agent, even when administered in large doses, slightly affects the quantity of blood platelets. The aim of the present study was to analyse the effect of single intraperitoneal administration of CP (150mg/kg b.w.) on the quantitative changes in platelets obtained from the left and right ventricle of the heart, as well as to evaluate the occurrence of megakaryocytes in lung tissue depending on the period of time that passed from CP administration. In control subgroups, fewer platelets were found in the blood collected from the RV compared with the left ventricle at all time intervals. After 1 and 3 days following i.p, administration of CP, a decrease was observed in the number of platelets both in the blood from the right ventricle and left ventricle when compared with control. However, after 14 days, the number of platelets in the blood from the left ventricle was higher, compared with the left ventricle and right ventricle of control animals, and significantly higher (p<0.001747), compared with their number obtained from the right ventricle of CP-receiving animals. Simultaneous ultrastructural examinations with transmission electron microscopy revealed the increased number of platelets in the lung vascular bed of CPreceiving rats at all time intervals. However, megakaryocytes were found 7 and 14 days after administration of CP. The findings clearly indicate that the lungs could be a major place of thrombopoiesis following therapy with a single large dose of CP