4 research outputs found
Bicyclic Hybrid Sugars as Glycosidase Inhibitors: Synthesis and Comparative Study of Inhibitory Activities of Fused Oxa-Oxa, Oxa‑Aza, and Oxa-Carbasugar Hybrid Molecules
A few bicyclic hybrid sugar molecules
comprising of oxa-aza, oxa-oxa,
and oxa-carbasugar fused skeletons were designed and synthesized from
C-2 acetoxyglucal involving Ferrier rearrangement, Grignard addition,
and ring-closing metathesis as key steps. The inhibitory activities
of the synthesized molecules were tested against commercially available
enzymes, which revealed the sugar–piperidine and sugar–pyran
hybrids as potent and selective inhibitors