Signatures of the self-modulation instability of relativistic proton bunches in the AWAKE experiment

We investigate numerically the detection of the self-modulation instability in a virtual detector located downstream from the plasma in the context of AWAKE. We show that the density structures, appearing in the temporally resolving virtual detector, map the transverse beam phase space distribution at the plasma exit. As a result, the proton bunch radius that appears to grow along the bunch in the detector results from the divergence increase along the bunch, related with the spatial growth of the self-modulated wakefields. In addition, asymmetric bunch structures in the detector are a result of asymmetries of the bunch divergence, and do not necessarily reflect asymmetric beam density distributions in the plasma.Comment: Accepted for publication in NIM-A for the proceedings of the 3rd European Advanced Accelerator Workshop. 5 pages, 2 figure

Novel diagnostic for precise measurement of the modulation frequency of Seeded Self-Modulation via Coherent Transition Radiation in AWAKE

We present the set-up and test-measurements of a waveguide-integrated heterodyne diagnostic for coherent transition radiation (CTR) in the AWAKE experiment. The goal of the proof-of-principle experiment AWAKE is to accelerate a witness electron bunch in the plasma wakefield of a long proton bunch that is transformed by Seeded Self-Modulation (SSM) into a train of proton micro-bunches. The CTR pulse of the self-modulated proton bunch is expected to have a frequency in the range of 90-300 GHz and a duration of 300-700 ps. The diagnostic set-up, which is designed to precisely measure the frequency and shape of this CTR-pulse, consists of two waveguide-integrated receivers that are able to measure simultaneously. They cover a significant fraction of the available plasma frequencies: the bandwidth 90-140 GHz as well as the bandwidth 255-270 GHz or 170-260 GHz in an earlier or a latter version of the set-up, respectively. The two mixers convert the CTR into a signal in the range of 5-20 GHz that is measured on a fast oscilloscope, with a high spectral resolution of 1-3 GHz dominated by the pulse length. In this contribution, we will describe the measurement principle, the experimental set-up and a benchmarking of the diagnostic in AWAKE.Comment: Conference proceedings to 3rd European Advanced Accelerator Concepts Worksho

Zystoskopie bei einem Rind mit Urachus persistens-Ruptur

Die Arbeit beschreibt die klinischen, sonographischen und zystoskopischen Befunde sowie die Therapie bei einem 2-jährigen, 7 Monate trächtigen Braunviehrind mit Ruptur des Urachus persistens. Das Leitsymptom war ein birnförmiges Abdomen bei stark gestörtem Allgemeinbefinden. Die Blutuntersuchung ergab eine hochgradige Azotämie. Bei der Ultraschalluntersuchung wurde ein Aszites festgestellt, welcher aufgrund der massiv erhöhten Kreatininkonzentration im Punktat als Uroperitoneum klassiert wurde. Bei der Zystoskopie konnte das Endoskop über die Harnblase in einen persistierenden Urachus eingeführt werden. Aufgrund sämtlicher Befunde wurde die Diagnose Uroperitoneum infolge Ruptur eines Urachus persistens gestellt. Als Therapie wurde eine Laparotomie in der linken Flanke mit doppelter Ligation des Urachus durchgeführt. Innerhalb von wenigen Tagen normalisierte sich der Zustand des Rindes. Es hat inzwischen normal gekalbt und erfreut sich bester Gesundheit This case report describes the clinical, ultrasonographic and cystoscopic findings and treatment in a two-year-old Swiss Braunvieh heifer with rupture of a patent urachus. The lead signs in the seven-month-pregnant heifer were markedly abnormal general condition and demeanour and a pear-shaped abdomen. The heifer had severe azotaemia, and abdominal ultrasonography revealed ascites, which was diagnosed as uroperitoneum based on an elevated creatinine level in the fluid. A patent urachus was identified during cystoscopy; the endoscope could be advanced beyond the apex of the urinary bladder into the urachus. Based on all the findings, a diagnosis of uroperitoneum attributable to rupture of a patent urachus was made. The urachus was ligated twice via a left-flank laparotomy. The general condition normalised within a few days of surgery, and the patient calved normally and was in good health at follow-up evaluation

Experimental Observation of Energy Modulation in Electron Beams Passing Through Terahertz Dielectric Wakefield Structures

We report observation of a strong wakefield induced energy modulation in an energy-chirped electron bunch passing through a dielectric-lined waveguide. This modulation can be effectively converted into a spatial modulation forming micro-bunches with a periodicity of 0.5 - 1 picosecond, hence capable of driving coherent THz radiation. The experimental results agree well with theoretical predictions.Comment: v3. Reviewers' suggestions incorporated. Accepted by PR

British American Tobacco and the “insidious impact of illicit trade” in cigarettes across Africa

OBJECTIVES: To provide an overview of the complicity of British American Tobacco (BAT) in the illicit trade of cigarettes across the African continent in terms of rationale, supply routes and scale. METHODS: Analysis of internal BAT documents and industry publications. RESULTS: BAT has relied on illegal channels to supply markets across Africa since the 1980s. Available documents suggest smuggling has been an important component of BAT's market entry strategy in order to gain leverage in negotiating with governments for tax concessions, compete with other transnational tobacco companies, circumvent local import restrictions and unstable political and economic conditions and gain a market presence. BAT worked through distributors and local agents to exploit weak government capacity to gain substantial market share in major countries. CONCLUSIONS: Documents demonstrate that the complicity of BAT in cigarette smuggling extends to Africa, which includes many of the poorest countries in the world. This is in direct conflict with offers by the company to contribute to stronger international cooperation to tackle the illicit tobacco trade

Rational invariants of even ternary forms under the orthogonal group

In this article we determine a generating set of rational invariants of minimal cardinality for the action of the orthogonal group $\mathrm{O}_3$ on the space $\mathbb{R}[x,y,z]_{2d}$ of ternary forms of even degree $2d$. The construction relies on two key ingredients: On one hand, the Slice Lemma allows us to reduce the problem to dermining the invariants for the action on a subspace of the finite subgroup $\mathrm{B}_3$ of signed permutations. On the other hand, our construction relies in a fundamental way on specific bases of harmonic polynomials. These bases provide maps with prescribed $\mathrm{B}_3$-equivariance properties. Our explicit construction of these bases should be relevant well beyond the scope of this paper. The expression of the $\mathrm{B}_3$-invariants can then be given in a compact form as the composition of two equivariant maps. Instead of providing (cumbersome) explicit expressions for the $\mathrm{O}_3$-invariants, we provide efficient algorithms for their evaluation and rewriting. We also use the constructed $\mathrm{B}_3$-invariants to determine the $\mathrm{O}_3$-orbit locus and provide an algorithm for the inverse problem of finding an element in $\mathbb{R}[x,y,z]_{2d}$ with prescribed values for its invariants. These are the computational issues relevant in brain imaging.Comment: v3 Changes: Reworked presentation of Neuroimaging application, refinement of Definition 3.1. To appear in "Foundations of Computational Mathematics

Comparison of office, home and ambulatory blood pressure measurements in hypertensive and suspected hypertensive SWICOS participants.

PURPOSE Hypertension should be confirmed with the use of home BP measurement (HBPM) or 24h ambulatory BP measurement (ABPM). The aim of our study was to compare measurements obtained by OBPM, HBPM and ABPM in individuals with elevated OBPM participating in the population-based Swiss Longitudinal Cohort Study (SWICOS). MATERIAL AND METHODS Participants with OBPM ≥140/90 mmHg assessed their BP using HBPM and ABPM. The cut-off for hypertension was ≥135/85 mmHg for HBPM, ≥130/80 mmHg for ABPM. White-coat hypertension (WCH) was defined as normal HPBM and ABPM in participants not taking antihypertensive drugs. Uncontrolled hypertension was defined as hypertension in HBPM or ABPM despite antihypertensive treatment. RESULTS Of 72 hypertensive subjects with office BP ≥140/90 mmHg and valid measurements of HBPM and ABPM, 39 were males (aged 62.8 ± 11.8y), 33 were females (aged 57.4 ± 14.2y). Hypertension was confirmed with HBPM and ABPM in 17 participants (24%), with ABPM only in 24 further participants (33%), and with HBPM only in 2 further participants (3%). Participants who had hypertension according to ABPM but not HBPM were younger (59 ± 11 y versus 67 ± 16 y; p < 0.001) and more frequently still working (83% versus 23%; p < 0.001). The prevalence of WCH was 28%. Among the 32 subjects taking antihypertensive drugs, uncontrolled hypertension was found in 49%. CONCLUSION This population-based study found a high prevalence of WCH and potential uncontrolled hypertension among individuals with elevated OBPM. This study, therefore, supports the ESH recommendations of complementing OBPM by ABPM or HBPM. The use of HBPM instead of ABPM for the confirmation of hypertension in individuals with elevated OBPM might lead to underdiagnosis and uncontrolled hypertension, in particular in the younger working population. In these individuals, this study suggests using ABPM instead of HBPM