480 research outputs found
Urban Lymphatic Filariasis in the Metropolis of\ud Dar es Salaam, Tanzania
The last decades have seen a considerable increase in urbanization in Sub-Saharan Africa, and it is estimated that over 50% of the population will live in urban areas by 2040. Rapid growth of cities combined with limited economic resources often result in informal settlements and slums with favorable conditions for proliferation of vectors of lymphatic filariasis (LF). In Dar es Salaam, which has grown more than 30 times in population during the past 55 years (4.4 million inhabitants in 2012), previous surveys have indicated high prevalences of LF. This study investigated epidemiological aspects of LF in Dar es Salaam, as a background for planning and implementation of control. Six sites with varying distance from the city center (3–30 km) and covering different population densities, socioeconomic characteristics, and water, sewerage and sanitary facilities were selected for the study. Pupils from one public primary school at each site were screened for circulating filarial antigen (CFA; marker of adult worm infection) and antibodies to Bm14 (marker of exposure to transmission). Community members were examined for CFA, microfilariae and chronic manifestations. Structured questionnaires were administered to pupils and heads of community households, and vector surveys were carried out in selected households. The study indicated that a tremendous decrease in the burden of LF infection had occurred, despite haphazard urbanisation. Contributing factors may be urban malaria control targeting Anopheles vectors, short survival time of the numerous Culex quinquefasciatus vectors in the urban environment, widespread use of bed nets and other mosquito proofing measures, and mass drug administration (MDA) in 2006 and 2007. Although the level of ongoing transmission was low, the burden of chronic LF disease was still high. The development has so far been promising, but continued efforts are necessary to ensure elimination of LF as a public health problem. These will include improving the awareness of people about the role of mosquitoes in transmission of LF, more thorough implementation of environmental sanitation to reduce Cx. Quinquefasciatus breeding, continued MDA to high-risk areas, and set-up of programmes for management of chronic LF disease
Foot-and-mouth disease in Tanzania from 2001 to 2006.
Foot-and-mouth disease (FMD) is endemic in Tanzania, with outbreaks occurring almost each year in different parts of the country. There is now a strong political desire to control animal diseases as part of national poverty alleviation strategies. However, FMD control requires improving the current knowledge on the disease dynamics and factors related to FMD occurrence so control measures can be implemented more efficiently. The objectives of this study were to describe the FMD dynamics in Tanzania from 2001 to 2006 and investigate the spatiotemporal patterns of transmission. Extraction maps, the space-time K-function and space-time permutation models based on scan statistics were calculated for each year to evaluate the spatial distribution, the spatiotemporal interaction and the spatiotemporal clustering of FMD-affected villages. From 2001 to 2006, 878 FMD outbreaks were reported in 605 different villages of 5815 populated places included in the database. The spatial distribution of FMD outbreaks was concentrated along the Tanzania-Kenya, Tanzania-Zambia borders, and the Kagera basin bordering Uganda, Rwanda and Tanzania. The spatiotemporal interaction among FMD-affected villages was statistically significant (P≤0.01) and 12 local spatiotemporal clusters were detected; however, the extent and intensity varied across the study period. Dividing the country in zones according to their epidemiological status will allow improving the control of FMD and delimiting potential FMD-free areas
Over-diagnosis of malaria is not a lost cause.
BACKGROUND: Recent studies have highlighted the over-diagnosis of malaria in clinical settings in Africa. This study assessed the impact of a training programme implemented as part of an intervention trial on diagnostic behaviour of clinicians in a rural district hospital in a low-moderate malaria transmission setting. METHODS: From the beginning of 2005, a randomized controlled trial (RCT) of intermittent preventive treatment for malaria in infants (IPTi) has been conducted at the study hospital. As part of the RCT, the study team offered laboratory quality assurance, and supervision and training of paediatric ward staff using information on malaria epidemiology in the community. Data on clinical and blood slide confirmed cases of malaria from 2001 to 2005 were extracted from the hospital records. RESULTS: The proportion of blood slides positive for malaria parasites had decreased from 21% in 2001 to 7% in 2005 (p < .01). The proportion of outpatient and inpatient cases diagnosed as malaria ranged between 34% and 28% from 2001 to 2004 and this decreased substantially to 17% after the introduction of the package of training and support in 2005 (p < .01). There was no clear trend in the ratio of blood slide examined versus total diagnosis of malaria. CONCLUSION: It may be possible to change the diagnostic behaviour of clinicians by rigorous training using local malaria epidemiology data and supportive supervision
Prevalence and awareness of type 2 diabetes mellitus among adult population in Mwanza city, Tanzania
Type 2 diabetes mellitus (T2DM) prevalence is increasing rapidly around the world. This cross-sectional study was conducted to assess the prevalence and awareness of type 2 diabetes mellitus in Mwanza city, Tanzania. A multistage random sampling technique was used to obtain representative subjects. Information about causes and risk factors were collected using structured questionnaire. In addition, community random blood glucose testing was employed to identify those at risk. Subjects with ≥200mg/dl on the following day were subjected to fasting blood glucose testing and they were confirmed to have T2DM if they had blood glucose level of ≥126mg/dl. In each subject, height, weight, waist and hip circumferences and total fat and fat free mass were measured using standard procedures. A total of 640 participants were included in this study, 55% were females and 45% were males. Mean age of the respondent was 43.84 ± 10.80 years. Most (46.4%) respondents were in the age group 30-40 years. Mean age for females was 44.0 ± 10.31 years while for males was 43.6 ± 11.3 years (Table 1). Overall prevalence of T2DM was 11.9%, (n=76). Prevalence was high in females (7.2%; n=46) than in males (4.7%; n=30). The age between 41-50 years had the highest prevalence of T2DM 28.6% followed by 51-60 years age group (17.2%). Significant independent associations were found for age (OR 3.88, 95% CI: 2.16-6.95) positive first degree relative with T2DM (OR 1.34; 95%C: 1.10-1.64) alcohol intake (OR 1.23; 95%CI: 1.02-1.48,) smoking (OR 3.86; 95%CI: 2.57-5.78) and hypertension (OR 0.096; 95%CI: 1.954-18.251). Only 49.2 (n=315) of the respondents knew about the causes and symptoms of T2DM. Public education on T2DM should be emphasized and routine measurement of blood glucose levels is recommended among adults
Ferroelectric Polarization Dependent Interactions at Pd-LiNbO\u3csub\u3e3\u3c/sub\u3e(0001) Interfaces
A combination of Auger electron spectroscopy and temperature-programed desorption was used to characterize the growth and interaction of Pd films with positively and negatively terminated ferroelectric LiNbO3(0001) surfaces. The growth mode of vapor-deposited Pd layers at 300 K was found to be dependent on the direction of the ferroelectric polarization with layer-by-layer growth occurring on the negative (c−) surface and particle formation occurring on the positive (c+) surface. The Pd metal layers were also found to be more thermally stable on the c− surface relative to the c+ surface. These results provide another example of how the polarization orientation in ferroelectric materials affects adsorption and reaction on their exposed surfaces
The Sexual health of pupils in years 4 to 6 of primary schools in rural Tanzania
Background/objectives: There is an urgent need for effective interventions to improve the sexual and\ud
reproductive health of adolescents. Reliable data on the sexual health of adolescents are needed to guide\ud
the development of such interventions. The aim was to describe the sexual health of pupils in years 4 to 6 of\ud
121 rural primary schools in north western Tanzania, before the implementation of an innovative sexual\ud
health intervention in 58 of the schools.\ud
Methods: A cross sectional survey of primary school pupils in rural Tanzania was carried out. The study\ud
population comprised pupils registered in years 4 to 6 of 121 primary schools in 20 rural communities in\ud
1998. Basic demographic information was collected from all pupils seen. Those born before 1 January\ud
1985 (aged approximately 14 years and over) were invited to participate in the survey, and asked about\ud
their knowledge and attitudes towards sexual health issues, and their sexual experience. A urine specimen\ud
was requested and tested for HIV, Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and, for\ud
females, pregnancy.\ud
Results: 9283 pupils born before 1 January 1985 were enrolled and provided demographic information\ud
and a urine sample. Male pupils were significantly older than females (mean age 15.5 years v 14.8 years,\ud
p,0.001), but all other demographic characteristics were similar between the sexes. 14 (0.2%) of the\ud
enrolled pupils (four male and 10 female) were HIV positive, 83 (0.9%) were positive for CT, and 12\ud
(0.1%) for NG. 32 female pupils (0.8%) were positive by pregnancy test. Sexual experience was reported\ud
by one fifth of primary school girls, and by almost half of boys. Only 45/114 (39%) girls with biological\ud
markers of sexual activity reported having had sex.\ud
Conclusions: HIV, CT, NG, and pregnancy were present though at relatively low levels among pupils in\ud
years 4 to 6 of primary school. A high proportion of pupils with a biological marker of sexual activity\ud
denied ever having had sex. Alternative ways of collecting sensitive data about the sexual behaviour of\ud
school pupils should be explored
Role of cattle treated with deltamethrine in areas with a high population of Anopheles arabiensis in Moshi, Northern Tanzania
Malaria control measures were initiated from in October 2005 to August 2006 in the Lower Moshi irrigation schemes, Tanzania. This manuscript reports on the entomological evaluation of the impact of pyrethroid-treated cattle in reducing the population of the Anopheles arabiensis for selected houses in the Lower Moshi irrigation scheme. Cattle were sprayed with the pyrethroid (deltamethrin) acaricide. Grazing and non-grazing cattles were compared and assessed for difference in knockdown resistance (kdr) time using cone or contact bioassay and residual effect (mortality). In experimental huts, mortality was compared between the huts with treated and untreated cattle. Results from contact bioassays of cattle treated with deltamethrin showed a knockdown effect of 50% within 21 days for grazing cattle and 29 days for non-grazing cattle. Residual effect at 50% was achieved within 17 days for grazing cattle compared to 24 days for inshed cattle. In discussing the results, reference has been made to the exophilic and zoophilic tendencies of An. arabiensis, which are conducive for zooprophylaxis. Experimental studies in Verandah huts at Mabogini compared An. arabiensis and Culex spp collected from huts with different baits, i e. human, untreated cow and treated cow. Results indicate higher mortality rates in mosquitoes collected from the hut containing the treated cow (mean = 2) compared to huts with untreated cow (mean = 0.3) and human (mean = 0.8). A significantly higher number of Culex spp. was recorded in huts with treated cows compared to the rest. This study has demonstrated the role of cattle treated with pyrethroid in the control of malaria and reduction of vector density. It showed that, in areas with a predominant An. arabiensis population, cattle should be placed close to dwelling houses in order to maximize the effects of zooprophylaxis. Protective effects of cattle can further be enhanced by regular treatment with pyrethroids at least every three weeks. This paper demonstrates that cattle can be considered as Insecticide-Treated Material (ITM) as long as acaricide treatment is conducted regularly
Increased tolerance of Anopheles gambiae s.s. to chemical insecticides after exposure to agrochemical mixture
Resistance of mosquitoes to insecticides is mainly attributed to their adaptation to insecticide-based vector control interventions. Although pesticides used in agriculture have been frequently mentioned as an additional force driving the selection of resistance, only a few studies were dedicated to validate this hypothesis. The objective of this study was to investigate the effect of exposure of the malaria mosquito, Anopheles gambiae s.s. larvae for 72h to sub-lethal concentrations of the agrochemical mixture (pesticides, herbicides and fungicides). Their subsequent tolerances were measured to deltamethrin (pyrethroid), DDT (organochlorine) and bendiocarb (carbamate) currently used for vector control. The mean LC50 was determined and tolerance ratios for larvae exposed to agrochemical comparatively with unexposed larvae were calculated and expressed as fold increased tolerance. Bioassays revealed a significant increase in larval tolerance to detamethrin (1.83-2.86 fold), DDT (1.31-1.53 fold) and bendiocarb (1.14-1.19 fold) following exposure to 0.1 µM and 1µM agrochemical mixture. The observed increased tolerance in this study is likely to be based on metabolic resistance mechanisms. Overall, this study reveals the potential of agrochemicals to increase the tolerance of mosquito larvae to chemical insecticides
Experimental hut and bioassay evaluation of the residual activity of a polymer-enhanced suspension concentrate (SC-PE) formulation of deltamethrin for IRS use in the control of Anopheles arabiensis.
BACKGROUND: The Stockholm Convention on Persistent Organic Pollutants (POPs) came into effect in 2004; the use of DDT for malaria control has been allowed to continue under exemption since then due to a perceived absence of equally effective and efficient alternatives. Alternative classes of insecticide for indoor residual spraying (IRS) have a relatively short residual duration of action (2-6 months according to WHO). In areas of year-round transmission multiple spray cycles are required, resulting in significantly higher costs for malaria control programs and user fatigue. This study evaluated performance of a new formulation of deltamethrin (pyrethroid) with polymer (SC-PE) to prolong the effective residual action to >6 months. METHODS: Deltamethrin SC-PE was evaluated alongside an existing water dispersible granule (WG) formulation and DDT water dispersible powder (WP) in laboratory and hut bioassays on mud, concrete, palm thatch and plywood substrates. An experimental hut trial was conducted in Lower Moshi Rice Irrigation Zone, Tanzania from 2008-2009 against wild, free-flying, pyrethroid susceptible An. arabiensis. Performance was measured in terms of insecticide-induced mortality, and blood-feeding inhibition. Bioassays were carried out monthly on sprayed substrates to assess residual activity. RESULTS: Bioassays in simple huts (designed for bioassay testing only) and experimental huts (designed for testing free flying mosquitoes) showed evidence that SC-PE improved longevity on mud and concrete over the WG formulation. Both deltamethrin SC-PE and WG outperformed DDT in bioassays on all substrates tested in the laboratory and simple huts. In experimental hut trials SC-PE, WG and DDT produced high levels of An. arabiensis mortality and the treatments were equivalent over nine months' duration. Marked seasonal changes in mortality were recorded for DDT and deltamethrin treatments, and may have been partly influenced by outdoor temperature affecting indoor resting duration of mosquitoes on sprayed surfaces, although no clear correlation was demonstrated. CONCLUSIONS: There is a limited range of alternative insecticides for IRS, and deltamethrin SC-PE is likely to have an important role as part of a rotation strategy with one or more different insecticide classes rotated annually, particularly in areas that currently have low levels of pyrethroid resistance or low LLIN coverage and year-round malaria transmission
Indoor residual spraying with microencapsulated DEET repellent (N, N-diethyl-m-toluamide) for control of Anopheles arabiensis and Culex quinquefasciatus.
BACKGROUND: Evolution of insecticide resistance in Anopheles gambiae complex necessitates evaluation of alternative chemical classes to complement existing insecticides for long lasting insecticidal nets (LLIN) and indoor residual spraying (IRS). Microencapsulated (MC) DEET (N, N-diethyl-m-toluamide) is a formulation of the popular repellent, which gives long lasting activity when applied to nets. Its suitability for IRS use has not been evaluated before. This study assessed the efficacy of DEET MC, for IRS in experimental huts. METHODS: DEET MC was tested alongside standard repellent and non-repellent residual insecticides: lambdacyhalothrin, permethrin, pirimiphos methyl and DDT. Residual formulations of these compounds were sprayed on plywood panels attached to walls of experimental huts to assess efficacy against pyrethroid resistant, wild free-flying Anopheles arabiensis and Culex quinquefasciatus. The panel treatments were rotated weekly between huts. RESULTS: The overall mortalities of An. arabiensis induced by the various treatments (range: 76-86%) were significantly greater than mortality in the untreated control (8%, P < 0.001). Mortality of An. arabiensis in DEET sprayed huts (82%) was higher than in lambdacyhalothrin CS (76%, P = 0.043) but not significantly different to pirimiphos methyl CS (86%, P = 0.204) or DDT huts (81%, P = 0.703). Against Cx. quinquefasciatus DEET MC was less effective, inducing lower mortality (29%) than other treatments. An arabiensis blood feeding rates were higher in the unsprayed control (34%) than in sprayed huts (range between treatments: 19-22%, P < 0.002), and DEET provided equivalent or superior blood feeding inhibition (44%) to other insecticides. Against Cx. quinquefasciatus there was no significant reduction in blood-feeding for any treatment relative to the control. There was a significantly higher exiting of An. arabiensis from huts sprayed with DEET (98%), lambdacyhalothrin (98%) and permethrin (96%) relative to the control (80%, P < 0.01). Exiting rates of Cx. quinquefasciatus did not differ between treatment huts and the control. CONCLUSION: Microencapsulated DEET acts like an insecticide at ambient temperature and induces mosquito mortality when applied to walls made from wooden panels. This trial demonstrated the potential of microencapsulated DEET to control An. arabiensis and warrants further studies of residual activity on interior substrates
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