How Can We Obtain a Large Majorana-Mass in Calabi-Yau Models ?

In a certain type of Calabi-Yau superstring models it is clarified that the symmetry breaking occurs by stages at two large intermediate energy scales and that two large intermediate scales induce large Majorana-masses of right-handed neutrinos. Peculiar structure of the effective nonrenormalizable interactions is crucial in the models. In this scheme Majorana-masses possibly amount to O(10^{9 \sim 10}\gev) and see-saw mechanism is at work for neutrinos. Based on this scheme we propose a viable model which explains the smallness of masses for three kind of neutrinos $\nu _e, \nu _{\mu} \ {\rm and}\ \nu _{\tau}$. Special forms of the nonrenormalizable interactions can be understood as a consequence of an appropriate discrete symmetry of the compactified manifold.Comment: 30-pages + 6-figures, LaTeX, Preprint DPNU-94-02, AUE-01-9

Relationship between period of survival and clinicopathological characteristics in patients with colorectal liver metastasis

AIM: Cancer death in the early period after hepatectomy still occurs in patients with colorectal liver metastasis (CLM). We examined the relationship between clinicopathological parameters and survival periods in 130 CLM patients who underwent hepatectomy. PATIENTS/METHODS: Patients were divided into four groups: Group 1 (5-year survivors without tumor relapse), Group 2 (survivors at 2-5years), Group 3 (cancer death at 2-5years), and Group 4 (cancer death within 2years). RESULTS: A short surgical margin was frequent in Group 4 compared to Group 1 (31 vs. 78%, P<0.05). Primary node-positive status, absence of fibrous pseudo-capsular formation, higher Clinical Risk Score, and tumor recurrence within 12months were frequent in Group 4 (P<0.05). Multivariate analysis revealed a short surgical margin (HR; 3.5) and early tumor relapse (HR; 5.9) as independently significant related parameters (P<0.05). CONCLUSIONS: Sufficient surgical margins and careful follow-up for early tumor relapse may be important for improving postoperative outcomes for CLM patients