95 research outputs found
Implantation of Autologous Bone-Marrow-Derived Cells Reconstructs Functional Urethral Sphincters in Rabbits
The purpose of this study was to determine if implantation of autologous bone-marrow-derived cells has the potential to treat stress urinary incontinence caused by intrinsic sphincter deficiency. Bone marrow cells harvested from femurs of New Zealand White rabbits were cultured for 10 days. Seven days before implantation, the urethral sphincters located at the internal urethral orifice were cryo-injured by spraying liquid nitrogen for 15 s. The cultured autologous bone-marrow-derived cells were implanted 7 days after cryo-injury. For controls, cell-free solutions were injected. At 7 and 14 days after implantation, leak point pressures were determined and the urethral sphincters were examined by immunohistochemistry. At 7 and 14 days, the cell-implanted regions contained numerous striated and smooth muscle-like cells expressing myoglobin and smooth muscle actin, respectively. The proportions of myoglobin- and smooth muscle actin-expressing areas in both the 7- and 14-day cell-implanted regions were significantly higher than in controls. By 14 days, these differentiated cells formed contacts with similar cells, creating layered muscle structures. At that time, the leak point pressure of the cell-implanted rabbits was significantly higher than that of the controls. In conclusion, autologous bone-marrow-derived cells can reconstruct functional urethral sphincters.ArticleTISSUE ENGINEERING PART A. 17(41098):1069-1081 (2011)journal articl
Visible light induced electron transfer behavior of a CeO2-loaded HfO2/carbon cluster nanocomposite material
The microwave-irradiated calcination of HfOCl2/starch complex I under an air atmosphere produced the HfO2/carbon cluster composite material which is denoted as Ic. The obtained composite material could decompose methylene blue under the irradiation of light (λ > 460 nm). The surface of Ic was loaded with CeO2 particles to obtain CeO2-loaded composite material, which can decompose the aqueous silver nitrate solution and produce O2 and Ag in the ratio of 1:4.2. Water photo-decomposition experiment was also carried out using Pt-modified composite materials
Patient outcomes of monotherapy with hypofractionated three-dimensional conformal radiation therapy for stage T2 or T3 non-small cell lung cancer: a retrospective study
Solitary pulmonary metastasis from prostate cancer with neuroendocrine differentiation: a case report and review of relevant cases from the literature
Closure of iatrogenic large mucosal and full-thickness defects of the stomach with endoscopic interrupted sutures in in vivo porcine models: are they durable enough?
Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors
Studies on the Gelation Mechanism of Polysaccharides, and Development and Application of Fucoidan from Commercially Cultured Cladosiphon okamuranus
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