Sepiolite with enhanced chemical reactivity as filler for rubber compounds

Reinforcing fillers are essential ingredients of rubber composites and, among them, inorganic oxides/hydroxides play a crucial role. Silica, with adequate coupling agents, is the best filler for tyre compounds with low energy dissipation and fuel consumption [1]. In recent years, interest has been increasing for biosourced fillers. Sepiolite is one of the most studied, thanks to its nanometric size and high aspect ratio [1-2]. However, sepiolite can hardly behave as a reinforcing filler, without establishing a chemical interaction with the rubber matrix. It is possible to pursue such objective by using an efficient coupling agent. In this study, sepiolite was functionalized with a pyrrole derivative, (2,5-dimethyl-1-(3-(triethoxysilyl) propyl)-1H-pyrrole) (APTESP), by simply mixing in water and heating, performing first evaporation and then the functionalization reaction. The Sepiolite/APTESP adduct was used as reinforcing filler in NR based composites, as the only filler or in a hybrid filler system with carbon black. The composites were prepared via melt blending in internal mixers. Sulfur based crosslinking was carried out and characterization was performed by means of dynamic-mechanical and tensile tests. Results The adduct Sepiolite/APTESP was successfully prepared, by using water as the reaction medium. The amount of APTESP was between 5 and 10% and the functionalization yield was higher than 70%. Sepiolite promoted the dynamic-mechanical reinforcement of the rubber composites, thanks to APTESP as coupling agent. The mechanical percolation threshold in sepiolite, as the only filler in NR, was observed at a sepiolite content of about 15 phr. When sepiolite/APTESP were used in place of CB, similar or lower values of hysteresis were obtained

The use of Genetic Algorithms to solve the allocation problems in the Life Cycle Assessment

The paper applies a GA (Genetic Algorithms) to a multi-output productive process of essential oils, natural and concen-trated juices from oranges and lemonsThe results obtained for the case study taken into consideration showed that the application of GA allows to respect the energ y and mass balances for the examined system

Heterogeneity of neuroinflammatory responses in amyotrophic lateral sclerosis: A challenge or an opportunity?

Amyotrophic Lateral Sclerosis (ALS) is a complex pathology: (i) the neurodegeneration is chronic and progressive; it starts focally in specific central nervous system (CNS) areas and spreads to different districts; (ii) multiple cell types further than motor neurons (i.e., glial/immune system cells) are actively involved in the disease; (iii) both neurosupportive and neurotoxic neuroinflammatory responses were identified. Microglia cells (a key player of neuroinflammation in the CNS) attracted great interest as potential target cell population that could be modulated to counteract disease progression, at least in preclinical ALS models. However, the heterogeneous/multifaceted microglia cell responses occurring in different CNS districts during the disease represent a hurdle for clinical translation of single-drug therapies. To address this issue, over the past ten years, several studies attempted to dissect the complexity of microglia responses in ALS. In this review, we shall summarize these results highlighting how the heterogeneous signature displayed by ALS microglia reflects not only the extent of neuronal demise in different regions of the CNS, but also variable engagement in the attempts to cope with the neuronal damage. We shall discuss novel avenues opened by the advent of single-cell and spatial transcriptomics technologies, underlining the potential for discovery of novel therapeutic targets, as well as more specific diagnostic/prognostic not-invasive markers of neuroinflammation

Motor skills in children with primary headache: A pilot case-control study

Background: Headache is the most common painful manifestation in the developmental age, often accompanied by severe disability such as scholastic absenteeism, low quality of academic performance and compromised emotional functioning. The aim of the study is to evaluate praxic abilities in a population of children without aural migraine. Materials and methods: The test population consists of 10 subjects without migraine without aura (MwA), (8 Males) (mean age 8.40, SD ± 1.17) and 11 healthy children (7 Males) (mean age 8.27; SD ± 1.10; p = 0.800). All subjects underwent evaluation of motor coordination skills through the Battery for Children Movement Assessment (M-ABC). Results: The two groups (10 MwA vs 11 Controls) were similar for age (8.40 ± 1.17 vs 8.27 ± 1.10; p = 0.800), sex (p = 0.730), and BMI (p = 0.204). The migraine subjects show an average worse performance than the Movement ABC; specifically, migraineurs show significantly higher total score values (31.00 ± 23.65 vs 4.72 ± 2.61; p = 0.001), manual dexterity (12.10 ± 11.20 vs 2.04 ± 2.65; p = 0.009) and balance (14.85 ± 10.08 vs. 1.04 ± 1.05; p <0.001). The mean percentile of migraine performance is significantly reduced compared to controls (9.00 ± 3.82 vs 51.00 ± 24.34, p <0.001) (Table 1). Conclusion: Migraine can alter many cognitive and executive functions such as motor skills in developmental age

Animals-assisted therapy: A brief review

In rehabilitative setting, the presence of animals can be considered as an important stimulus for verbal and social communication, and for mood regulation. Interaction with an animal is beneficial for children's development and numerous psychological tests have revealed that growing up with pets has a beneficial effect on children's self-esteem and self-confidence, can improve empathy, a sense of responsibility and cognitive development, as well as social status within the peer group

Neuropsychomotricity in water: A new rehabilitative tool for neruodevelop-mental disorders

Neuropsychomotricity in water is a rehabilitative practice that avails itself just of the liquid element, as a mediator of relationships: in water yes they upset all dynamics, be they relational, of equilibrium, of movement and perception, due to the fact that proprioceptive sensations, created by bodily contact with water, they are different than those generated by contact with air

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cells (iPSCs). Here we reprogrammed primary fibroblasts from two patients with familial Alzheimer's disease, both caused by a duplication of the amyloid-β precursor protein gene (APP; termed APP(Dp)), two with sporadic Alzheimer's disease (termed sAD1, sAD2) and two non-demented control individuals into iPSC lines. Neurons from differentiated cultures were purified with fluorescence-activated cell sorting and characterized. Purified cultures contained more than 90% neurons, clustered with fetal brain messenger RNA samples by microarray criteria, and could form functional synaptic contacts. Virtually all cells exhibited normal electrophysiological activity. Relative to controls, iPSC-derived, purified neurons from the two APP(Dp) patients and patient sAD2 exhibited significantly higher levels of the pathological markers amyloid-β(1-40), phospho-tau(Thr 231) and active glycogen synthase kinase-3β (aGSK-3β). Neurons from APP(Dp) and sAD2 patients also accumulated large RAB5-positive early endosomes compared to controls. Treatment of purified neurons with β-secretase inhibitors, but not γ-secretase inhibitors, caused significant reductions in phospho-Tau(Thr 231) and aGSK-3β levels. These results suggest a direct relationship between APP proteolytic processing, but not amyloid-β, in GSK-3β activation and tau phosphorylation in human neurons. Additionally, we observed that neurons with the genome of one sAD patient exhibited the phenotypes seen in familial Alzheimer's disease samples. More generally, we demonstrate that iPSC technology can be used to observe phenotypes relevant to Alzheimer's disease, even though it can take decades for overt disease to manifest in patients

A PC-Based Instrument for Automatic Monitoring and Control of a CPVT Power Plant

A PC-based instrument has been developed for the monitoring and control of a concentrated photovoltaic and thermal (CPVT) power plant. The instrument allows acquiring both electrical and thermal quantities. Moreover it implements the solar tracking algorithm used to optimize the power production

Analysis of appeals against the ruling of occupational physicians lodged with the Prevention and Occupational Epidemiology Operative Unit, ASP Palermo (Palermo Health Authority), from 2008-2010

Introduction: The responsibility of the Department for Prevention and Safety at the workplace of the Palermo Health Authority (ASP) is to monitor and coordinate the activity of occupational physicians operating in Palermo and its province. One of its obligations is to examine appeals “against the judgment of occupational physicians”, “...and, after carrying out further investigation, confirm, modify or reverse the ruling itself ” (art. 41, par. 6, legislative Decree 81/08). Objectives: The purpose of this study was to analyze the appeals lodged against a “judgment of fitness for work” submitted to the “Health Prevention and Occupational Epidemiology Operative Unit” of the Department of Prevention and Safety at the Workplace of the ASP Palermo, from 2008 to 2010. Methods: The total number of appeals lodged during the three-year period was 211, 174 of which were finalized. Results: The most frequent job category among the appellants was that of blue-collar workers, in various sectors, covering 44.5% of the subjects under study (93 cases). In 64.2% of the processed appeals (131 cases), the judgment of the physician was modified, while in the remaining 36.8% (73 cases) it was confirmed.The work fitness judgment with restrictions was the category against which most appeals were lodged, and the diseases in question mostly concerned the osteoarticular and cardiovascular systems. Conclusion: In a context of continuous change in the labour field and the related risks to the health and safety of workers, the occupational physician must approach the worker in a comprehensive manner,through an assessment of the possible health problems and the working environment in which he/she operates