31 research outputs found

    A minimal HIV-AIDS infection model with general incidence rate and application to Morocco data

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    We study the global dynamics of a SICA infection model with general incidence rate. The proposed model is calibrated with cumulative cases of infection by HIV-AIDS in Morocco from 1986 to 2015. We first prove that our model is biologically and mathematically well-posed. Stability analysis of different steady states is performed and threshold parameters are identified where the model exhibits clearance of infection or maintenance of a chronic infection. Furthermore, we examine the robustness of the model to some parameter values by examining the sensitivity of the basic reproduction number. Finally, using numerical simulations with real data from Morocco, we show that the model predicts well such reality.Comment: This is a preprint of a paper whose final and definite form is with 'Statistics Opt. Inform. Comput.', Vol. 7, No 2 (2019). See [http://www.IAPress.org]. Submitted 16/Sept/2018; Revised 10 & 15/Dec/2018; Accepted 15/Dec/201

    Modeling and forecasting of COVID-19 spreading by delayed stochastic differential equations

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    The novel coronavirus disease (COVID-19) pneumonia has posed a great threat to the world recent months by causing many deaths and enormous economic damage worldwide. The first case of COVID-19 in Morocco was reported on 2 March 2020, and the number of reported cases has increased day by day. In this work, we extend the well-known SIR compartmental model to deterministic and stochastic time-delayed models in order to predict the epidemiological trend of COVID-19 in Morocco and to assess the potential role of multiple preventive measures and strategies imposed by Moroccan authorities. The main features of the work include the well-posedness of the models and conditions under which the COVID-19 may become extinct or persist in the population. Parameter values have been estimated from real data and numerical simulations are presented for forecasting the COVID-19 spreading as well as verification of theoretical results.publishe

    Dynamics of a Stochastic Viral Infection Model with Immune Response

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    The aim of this work is to study the dynamical behavior of a stochastic viral infection model which is formulated by four nonlinear stochastic differential equations to describe the interactions between virus, host cells, and immune response represented by cytotoxic T lymphocytes (CTL) cells. The infection transmission process is modeled by Hattaf-Yousfi incidence function which includes many special cases existing in the literature. The positivity of solutions is investigated. In addition, the extinction of the infection is established in terms of the basic reproduction number R0. Moreover, sufficient conditions for the fluctuation of solutions around the two infection equilibria are obtained. Numerical simulations are presented to illustrate our theoretical results

    Lyapunov functions and stability analysis of fractional-order systems

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    This study presents new estimates for fractional derivatives without singular kernels defined by some specific functions. Based on obtained inequalities, we give a useful method to establish the global stability of steady states for fractional-order systems and generalize some works existing in the literature. Finally, we apply our results to prove the global stability of a fractional-order SEIR model with a general incidence rate.FCTpublishe

    Modeling the spread of Covid-19 pandemic in Morocco

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    Nowadays, coronavirus disease 2019 (Covid-19) poses a great threat to public health and economy worldwide. Unfortunately, there is yet no effective drug for this disease. For this, several countries have adopted multiple preventive interventions to avoid the spread of Covid-19. Here, we propose a delayed mathematical model to predict the epidemiological trend of Covid-19 in Morocco. Parameter estimation and sensitivity analysis of the proposed model are rigorously studied. Moreover, numerical simulations are presented in order to test the effectiveness of the preventive measures and strategies that were imposed by the Moroccan authorities and also help policy makers and public health administration to develop such strategies.FCTpublishe
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