Effect of exercise training before mating on mRNA expression of breast cancer-related genes in offspring in rats | [Effet de l'entraînement physique avant l'accouplement sur l'expression de l'ARNm de gènes liés au cancer du sein chez la progéniture du rat]

Purpose. — Exercise is associated with reduced risk of breast cancer, however, effect of parental exercise on risk of breast cancer in children has not been studied. Thus, the aim of the present study was evaluating the effect of aerobic training of parents before pregnancy on the expression of some of the main genes in breast cancer in breast tissue of their offspring. Method. — Eighteen female and 6 male Sprague Dawley rats were randomly divided into two exercise training and control group. After training each male mated with 2 females. Parental aerobic training with moderate intensity was performed running on treadmill for 4 weeks, 5 sessions per week. Finally Pairs 4, 5, and 6 of adult breast tissues was performed to evaluate the expression of BRCA1, TP53, ER-, IGF-1 and IGF-1R

Effect of exercise training before mating on mRNA expression of breast cancer-related genes in offspring in rats

Purpose: Exercise is associated with reduced risk of breast cancer, however, effect of parental exercise on risk of breast cancer in children has not been studied. Thus, the aim of the present study was evaluating the effect of aerobic training of parents before pregnancy on the expression of some of the main genes in breast cancer in breast tissue of their offspring. Method: Eighteen female and 6 male Sprague Dawley rats were randomly divided into two exercise training and control group. After training each male mated with 2 females. Parental aerobic training with moderate intensity was performed running on treadmill for 4 weeks, 5 sessions per week. Finally Pairs 4, 5, and 6 of adult breast tissues was performed to evaluate the expression of BRCA1, TP53, ER-α, IGF-1 and IGF-1R. Results: We found that prepregnancy moderate aerobic training of mother, especially along with father caused a significant increase in the mRNA of the BRCA1, P53 and ER-α genes, and a significant reduction in IGF-1 and IGF-1R. Conclusion: Exercise with moderate intensity before mating significantly affected the expression of BRCA1, P53, IGF-1, IGF-1R and ER-α genes. So we suggest that parents regular exercise before pregnancy can reduce the risk of breast cancer in children

The Effect of a 4 Week Isometric Handgrip Training on Changes of Peripheral Resistance and Blood Pressure in Women Suffering from Hypertension

Introduction: According to many studies, hypertension is considered as the second leading risk factor for coronary artery disease (CAD) and cardiac infarction after smoking The purpose of the present study was to investigate the effect of four weeks of Isometric Handgrip (IHG) Training on peripheral resistance and hypertension among hypertensive women. Methods: 14 middle aged women, aged 40 to 55 years old, were randomly selected. The training program included 4 sets of 2 minute IHG training with 1 minute resting between each period, performed 3 days a week for four weeks. Doppler ultrasound method was used to measure the vascular resistance. Data were analyzed using paired t-test. Results: According to the results, there was a significant difference between systolic blood pressure (p=0.006) and diastolic blood pressure (p=0.001) after 4 weeks of training. However, no significant difference was observed in vascular resistance (p=0.66). Conclusion: These results demonstrate that IHG training can reduce blood pressure in the hypertensive patients 24 hours after the last training session. It is also revealed that reduced blood pressure is not always associated with reduced vascular resistance and other influential factors may play a role in this regard

The Effect of 4-week Isometric Handgrip Exercise on Changes of Flow Mediated Dilation and Blood Pressure in Females Suffering from Hypertension

Introduction: Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality. As a matter of fact, hypertension appears to have a complex association with endothelial dysfunction. Hence, the purpose of this study was to evaluate the effect of 4-week isometric handgrip exercise on changes of flow mediated dilation (FMD) and blood pressure within females suffering from hypertension. Methods: The study participants consisted of 14 women aged 30-55, who were selected on the basis of their BMI as well as sort of consumed medicine for their hypertension. All the participants were trained three times per week for 4 weeks. FMD brachial artery and blood pressure were assessed before the exercises beginning and 24 hours after the last exercise session. The study data were analyzed using dependent t-test (pretest-posttest design) at significance level of p=0.05. Results: According to the study results, significant changes were observed in regard with FMD, systolic, and diastolic blood pressure (p= 0.001, p=0.006, and p= 0.001 respectively) in the experimented group. Conclusion: The findings of the present study demonstrated that isometric handgrip exercise, producing a positive effect on the endothelial function, can potentially reverse the endothelial dysfunction in females suffering from hypertension. &nbsp