The Fluctuations of the Quark Number and of the Chiral Condensate

The distributions of the quark number and chiral condensate over the gauge fields are computed for QCD in Euclidean space at nonzero quark chemical potential. As both operators are non-hermitian the distributions are in the complex plane. Moreover, because of the sign problem, the distributions are not real and positive. The computations are carried out within leading order chiral perturbation theory and give a direct insight into the delicate cancellations that take place in contributions to the total baryon number and the chiral condensate.Comment: 19 pages, 2 figure

Higher Derivative Gravity, Causality and Positivity of Energy in a UV complete QFT

In this note we discuss the relation between the constraints imposed by causality in the bulk of $AdS$ and the condition of positivity of the energy measured in ideal calorimeters in a collider experiment in the dual CFT. We first extend the analysis in the literature and recover all bounds imposed by causality of the boundary theory in the bulk dynamics for all polarizations of the graviton and the gauge boson field. These results translate to specific bounds for the ratio of central charges $\frac{a}{c}$ in the dual CFT, already found by analyzing the energy one point function. Then, we generalize this discussion and we study shock wave backgrounds in which we make manifest the relation between causality in the bulk and the three point function in the dual field theory. We remark that particular care has to be given to the exponentiation procedure of the three point function when solving the classical equations of motion in the higher gravity theory, as it is not clear that every theory will present causality problems. Finally, we present a field theoretic argument explaining the positivity of energy condition in any UV complete QFT.Comment: 31 pages, 3 figures; v2: references adde

Simple Quantum Systems in Spacetimes with Closed Timelike Curves

Three simple examples illustrate properties of path integral amplitudes in fixed background spacetimes with closed timelike curves: non-relativistic potential scattering in the Born approximation is non-unitary, but both an example with hard spheres and the exact solution of a totally discrete model are unitary.Comment: 15 pages, CALT-68-180

The averaged null energy condition for general quantum field theories in two dimensions

It is shown that the averaged null energy condition is fulfilled for a dense, translationally invariant set of vector states in any local quantum field theory in two-dimensional Minkowski spacetime whenever the theory has a mass gap and possesses an energy-momentum tensor. The latter is assumed to be a Wightman field which is local relative to the observables, generates locally the translations, is divergence-free, and energetically bounded. Thus the averaged null energy condition can be deduced from completely generic, standard assumptions for general quantum field theory in two-dimensional flat spacetime.Comment: LateX2e, 16 pages, 1 eps figur

AI-based multi-PRS models outperform classical single-PRS models

Polygenic risk scores (PRS) calculate the risk for a specific disease based on the weighted sum of associated alleles from different genetic loci in the germline estimated by regression models. Recent advances in genetics made it possible to create polygenic predictors of complex human traits, including risks for many important complex diseases, such as cancer, diabetes, or cardiovascular diseases, typically influenced by many genetic variants, each of which has a negligible effect on overall risk. In the current study, we analyzed whether adding additional PRS from other diseases to the prediction models and replacing the regressions with machine learning models can improve overall predictive performance. Results showed that multi-PRS models outperform single-PRS models significantly on different diseases. Moreover, replacing regression models with machine learning models, i.e., deep learning, can also improve overall accuracy

Restrictions on negative energy density in a curved spacetime

Recently a restriction ("quantum inequality-type relation") on the (renormalized) energy density measured by a static observer in a "globally static" (ultrastatic) spacetime has been formulated by Pfenning and Ford for the minimally coupled scalar field, in the extension of quantum inequality-type relation on flat spacetime of Ford and Roman. They found negative lower bounds for the line integrals of energy density multiplied by a sampling (weighting) function, and explicitly evaluate them for some specific spacetimes. In this paper, we study the lower bound on spacetimes whose spacelike hypersurfaces are compact and without boundary. In the short "sampling time" limit, the bound has asymptotic expansion. Although the expansion can not be represented by locally invariant quantities in general due to the nonlocal nature of the integral, we explicitly evaluate the dominant terms in the limit in terms of the invariant quantities. We also make an estimate for the bound in the long sampling time limit.Comment: LaTex, 23 Page

van Vleck determinants: traversable wormhole spacetimes

Calculating the van Vleck determinant in traversable wormhole spacetimes is an important ingredient in understanding the physical basis behind Hawking's chronology protection conjecture. This paper presents extensive computations of this object --- at least in the short--throat flat--space approximation. An important technical trick is to use an extension of the usual junction condition formalism to probe the full Riemann tensor associated with a thin shell of matter. Implications with regard to Hawking's chronology protection conjecture are discussed. Indeed, any attempt to transform a single isolated wormhole into a time machine results in large vacuum polarization effects sufficient to disrupt the internal structure of the wormhole before the onset of Planck scale physics, and before the onset of time travel. On the other hand, it is possible to set up a putative time machine built out of two or more wormholes, each of which taken in isolation is not itself a time machine. Such ``Roman configurations'' are much more subtle to analyse. For some particularly bizarre configurations (not traversable by humans) the vacuum polarization effects can be arranged to be arbitrarily small at the onset of Planck scale physics. This indicates that the disruption scale has been pushed down into the Planck slop. Ultimately, for these configurations, questions regarding the truth or falsity of Hawking's chronology protection can only be addressed by entering the uncharted wastelands of full fledged quantum gravity.Comment: 42 pages, ReV_TeX 3.

Averaged Energy Conditions in 4D Evaporating Black Hole Backgrounds

Using Visser's semi-analytical model for the stress-energy tensor corresponding to the conformally coupled massless scalar field in the Unruh vacuum, we examine, by explicitly evaluating the relevant integrals over half-complete geodesics, the averaged weak (AWEC) and averaged null (ANEC) energy conditions along with Ford-Roman quantum inequality-type restrictions on negative energy in the context of four dimensional evaporating black hole backgrounds. We find that in all cases where the averaged energy conditions fail, there exist quantum inequality bounds on the magnitude and duration of negative energy densities.Comment: Revtex, 13 pages, to appear in Phy. Rev.

From wormhole to time machine: Comments on Hawking's Chronology Protection Conjecture

The recent interest in ``time machines'' has been largely fueled by the apparent ease with which such systems may be formed in general relativity, given relatively benign initial conditions such as the existence of traversable wormholes or of infinite cosmic strings. This rather disturbing state of affairs has led Hawking to formulate his Chronology Protection Conjecture, whereby the formation of ``time machines'' is forbidden. This paper will use several simple examples to argue that the universe appears to exhibit a ``defense in depth'' strategy in this regard. For appropriate parameter regimes Casimir effects, wormhole disruption effects, and gravitational back reaction effects all contribute to the fight against time travel. Particular attention is paid to the role of the quantum gravity cutoff. For the class of model problems considered it is shown that the gravitational back reaction becomes large before the Planck scale quantum gravity cutoff is reached, thus supporting Hawking's conjecture.Comment: 43 pages,ReV_TeX,major revision