32 research outputs found

    Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis

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    D6 is a scavenging-receptor for inflammatory CC chemokines that are essential for resolution of inflammatory responses in mice. Here, we demonstrate that D6 plays a central role in controlling cutaneous inflammation, and that D6 deficiency is associated with development of a psoriasis-like pathology in response to varied inflammatory stimuli in mice. Examination of D6 expression in human psoriatic skin revealed markedly elevated expression in both the epidermis and lymphatic endothelium in "uninvolved" psoriatic skin (ie, skin that was more than 8 cm distant from psoriatic plaques). Notably, this increased D6 expression is associated with elevated inflammatory chemokine expression, but an absence of plaque development, in uninvolved skin. Along with our previous observations of the ability of epidermally expressed transgenic D6 to impair cutaneous inflammatory responses, our data support a role for elevated D6 levels in suppressing inflammatory chemokine action and lesion development in uninvolved psoriatic skin. D6 expression consistently dropped in perilesional and lesional skin, coincident with development of psoriatic plaques. D6 expression in uninvolved skin also was reduced after trauma, indicative of a role for trauma-mediated reduction in D6 expression in triggering lesion development. Importantly, D6 is also elevated in peripheral blood leukocytes in psoriatic patients, indicating that upregulation may be a general protective response to inflammation. Together our data demonstrate a novel role for D6 as a regulator of the transition from uninvolved to lesional skin in psoriasis

    Delineating Terminal Change in Subjective Well-Being and Subjective Health

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    The present study investigated whether several evaluative indicators of subjective well-being (SWB) and subjective health decline as death approaches and which of them shows a stronger decline. Using three-wave longitudinal data from deceased participants of the Cross-Sectional and Longitudinal Aging Study (N = 1,360; age range 75--94 at T1= Time 1), we found a stronger decline in most evaluative indicators when plotted by distance-to-death relative to distance from birth. After controlling for background characteristics and physical and cognitive functioning, death-related decline was still found for SWB but not for subjective health. Implications are discussed regarding the well-being paradox and the yet unclear mechanisms that link evaluative indicators to the dying process. Copyright 2009, Oxford University Press.
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