Stepping On Fall Prevention Project

Background: Falls are a major problem in the United States among the older adult population and provide opportunity for community outreach via student-led physical therapy projects. Objective: The purpose of this project was to investigate the relationship between fall related outcome measures and questionnaires with the completion of the Stepping On Fall Prevention program along with evaluating the benefits of Physical Therapy student development with participation in service learning projects. Methods: The research quantified the fall risk of 13 participants with assessment of: gait speed (Timed Up and Go), lower extremity strength (30-Second Chair Stand), balance (4-Stage Balance Test), and psychological factors (Stay Independent Questionnaire, Falls Efficacy Scale-International, and Geriatric Depression Scale). Results: Of the functional measures, significant improvements were observed in the Timed up and Go (TUG) (∆1.72s ± 1.66, p=0.003), the 30-second chair stand (∆4.54 ± 4.27, p= 0.002), Stage 4 of the 4-Stage Balance Test (∆3.37s ± 3.26, p= 0.003), and the Stay Independent questionnaire (∆1.77 ± 2.52, p=0.026). Conclusion: Stepping On demonstrated improvements in gait speed, strength, and balance. These improvements allow older adults to improve their overall safety in both their own homes and the community. More research is needed to evaluate the psychological benefits of completing Stepping On. Furthermore, service learning project opportunities should become more of a standard practice across physical therapy programs

Photodissociation of Conformer-Selected Ubiquitin Ions Reveals Site-Specific Cis/Trans Isomerization of Proline Peptide Bonds

Ultraviolet photodissociation (UVPD) of gas-phase proteins has attracted increased attention in recent years. This growing interest is largely based on the fact that, in contrast to slow heating techniques such as collision induced dissociation (CID), the cleavage propensity after absorption of UV light is distributed over the entire protein sequence, which can lead to a very high sequence coverage as required in typical top-down proteomics applications. However, in the gas phase, proteins can adopt a multitude of distinct and sometimes coexisting conformations, and it is not clear how this three-dimensional structure affects the UVPD fragmentation behavior. Using ion mobility–UVPD–mass spectrometry in conjunction with molecular dynamics simulations, we provide the first experimental evidence that UVPD is sensitive to the higher order structure of gas-phase proteins. Distinct UVPD spectra were obtained for different extended conformations of 11+ ubiquitin ions. Assignment of the fragments showed that the majority of differences arise from cis/trans isomerization of one particular proline peptide bond. Seen from a broader perspective, these data highlight the potential of UVPD to be used for the structural analysis of proteins in the gas phas

Termination of Electron Acceleration in Thundercloud by Intra/Inter-cloud Discharge

An on-ground observation program for high energy atmospheric phenomena in winter thunderstorms along Japan Sea has been performed via measurements of gamma-ray radiation, atmospheric electric field and low-frequency radio band. On February 11, 2017, the radiation detectors recorded gamma-ray emission lasting for 75 sec. The gamma-ray spectrum extended up to 20 MeV and was reproduced by a cutoff power-law model with a photon index of $1.36^{+0.03}_{-0.04}$, being consistent with a Bremsstrahlung radiation from a thundercloud (as known as a gamma-ray glow and a thunderstorm ground enhancement). Then the gamma-ray glow was abruptly terminated with a nearby lightning discharge. The low-frequency radio monitors, installed $\sim$50 km away from the gamma-ray observation site recorded leader development of an intra/inter-cloud discharge spreading over $\sim$60 km area with a $\sim$300 ms duration. The timing of the gamma-ray termination coincided with the moment when the leader development of the intra/inter-cloud discharge passed 0.7 km horizontally away from the radiation monitors. The intra/inter-cloud discharge started $\sim$15 km away from the gamma-ray observation site. Therefore, the glow was terminated by the leader development, while it did not trigger the lightning discharge in the present case.Comment: 12 pages, 4 figures, accepted for publication in Geophysical Research Letter

Casimir Energy for Spherical boundaries

Calculations of the Casimir energy for spherical geometries which are based on integrations of the stress tensor are critically examined. It is shown that despite their apparent agreement with numerical results obtained from mode summation methods, they contain a number of serious errors. Specifically, these include (1) an improper application of the stress tensor to spherical boundaries, (2) the neglect of pole terms in contour integrations, and (3) the imposition of inappropriate boundary conditions upon the relevant propagators. A calculation which is based on the stress tensor and which avoids such problems is shown to be possible. It is, however, equivalent to the mode summation method and does not therefore constitute an independent calculation of the Casimir energy.Comment: Revtex, 7 pages, Appendix added providing details of failure of stress tensor metho

Anisotropic static solutions in modelling highly compact bodies

Einstein field equations for anisotropic spheres are solved and exact interior solutions obtained. This paper extends earlier treatments to include anisotropic models which accommodate a wider variety of physically viable energy densities. Two classes of solutions are possible. The first class contains the limiting case $\mu\propto r^{-2}$ for the energy density which arises in many astrophysical applications. In the second class the singularity at the center of the star is not present in the energy density. The models presented in this paper allow for increasing and decreasing profiles in the behavior of the energy density.Comment: 9 pages, to appear in Pramana - J. Phy

Casimir Energy of a Spherical Shell

The Casimir energy for a conducting spherical shell of radius $a$ is computed using a direct mode summation approach. An essential ingredient is the implementation of a recently proposed method based on Cauchy's theorem for an evaluation of the eigenfrequencies of the system. It is shown, however, that this earlier calculation uses an improper set of modes to describe the waves exterior to the sphere. Upon making the necessary corrections and taking care to ensure that no mathematically ill-defined expressions occur, the technique is shown to leave numerical results unaltered while avoiding a longstanding criticism raised against earlier calculations of the Casimir energy.Comment: LaTeX, 14 pages, 1 figur

Breaking rotational symmetry in two-flavor color superconductors

The color superconductivity under flavor asymmetric conditions relevant to the compact star phenomenology is studied within the Nambu-Jona-Lasinio model. We focus on the effect of the deformation of the Fermi surfaces on the pairing properties and the energy budget of the superconducting state. We find that at finite flavor asymmetries the color superconducting BCS state is unstable towards spontaneous quadrupole deformation of the Fermi surfaces of the $d$ and $u$ quarks into ellipsoidal form. The ground state of the phase with deformed Fermi surfaces corresponds to a superposition of prolate and oblate deformed Fermi ellipsoids of $d$ and $u$ quarks.Comment: 6 pages, 4 figures. Parameter changes, references added, conclusions unchange

A new algorithm for anisotropic solutions

We establish a new algorithm that generates a new solution to the Einstein field equations, with an anisotropic matter distribution, from a seed isotropic solution. The new solution is expressed in terms of integrals of an isotropic gravitational potential; and the integration can be completed exactly for particular isotropic seed metrics. A good feature of our approach is that the anisotropic solutions necessarily have an isotropic limit. We find two examples of anisotropic solutions which generalise the isothermal sphere and the Schwarzschild interior sphere. Both examples are expressed in closed form involving elementary functions only.Comment: 16 pages, to appear in Pramana - J. Phy

Prognostic factors for chronic headache: A systematic review

OBJECTIVE: To identify predictors of prognosis and trial outcomes in prospective studies of people with chronic headache. METHODS: This was a systematic review of published literature in peer-reviewed journals. We included (1) randomized controlled trials (RCTs) of interventions for chronic headache that reported subgroup analyses and (2) prospective cohort studies, published in English, since 1980. Participants included adults with chronic headache (including chronic headache, chronic migraine, and chronic tension-type headache with or without medication overuse headache). We searched key databases using free text and MeSH terms. Two reviewers independently extracted data and assessed the methodologic quality of studies and overall quality of evidence identified using appropriate published checklists. RESULTS: We identified 16,556 titles, removed 663 duplicates, and reviewed 199 articles, of which 27 were included in the review-17 prospective cohorts and 10 RCTs with subgroup analyses reported. There was moderate-quality evidence indicating that depression, anxiety, poor sleep and stress, medication overuse, and poor self-efficacy for managing headaches are potential prognostic factors for poor prognosis and unfavorable outcomes from preventive treatment in chronic headache. There was inconclusive evidence about treatment expectations, age, age at onset, body mass index, employment, and several headache features. CONCLUSIONS: This review identified several potential predictors of poor prognosis and worse outcome postinterventions in people with chronic headache. The majority of these are modifiable. The findings also highlight the need for more longitudinal high-quality research of prognostic factors in chronic headache

The D/H Ratio in Interstellar Gas Towards G191-B2B

We reinvestigate the question of spatial variation of the local D/H abundance, using both archival GHRS spectra, and new echelle spectra of G191-B2B obtained with the Space Telescope Imaging Spectrograph (STIS) aboard HST. Our analysis uses stratified line-blanketed non-LTE model atmosphere calculations to determine the shape of the intrinsic WD Lyman-alpha profile and estimate the WD photospheric contamination of the interstellar lines. Although three velocity components were reported previously towards G191-B2B, we detect only two velocity components. The first component is at V(hel) ~ 8.6 km/s and the second at V(hel) ~ 19.3 km/s, which we identify with the Local Interstellar Cloud (LIC). From the STIS data we derive D/H = 1.60(+0.39,-0.27)X10^-5 for the LIC component, and D/H > 1.26X10^-5 for the 8.6 km/s component (uncertainties denote 2-sigma or 95% confidence limits). The STIS data provide no evidence for local or component-to-component variation in the D/H ratio. Despite using two velocity components for the profile fitting and using a more physically realistic WD Lyman-alpha profile for G191-B2B, our re-analysis of the GHRS data indicates a component-to-component variation as well as a variation of the D/H ratio in the LISM, neither of which are supported by the newer STIS data. We believe the most probable cause for this difference is the characterization of the background due to scattered light in the GHRS and STIS spectrographs. The two-dimensional MAMA detectors of STIS measure both the spatial and wavelength dependences of scattered light, allowing more accurate scattered light corrections than was possible with GHRS.Comment: Accepted for publication in Astrophysical Journal Letters. 10 pages + 3 figures. (Abstract is abridged.