Quantification of diffuse myocardial fibrosis using CMR extracellular volume fraction and serum biomarkers of collagen turnover with histologic quantification as standard of reference

International audienc

Segmentation of myocardial perfusion MR sequences with multi-band Active Appearance Models driven by spatial and temporal features

This work investigates knowledge driven segmentation of cardiac MR perfusion sequences. We build upon previous work on multi-band AAMs to integrate into the segmentation both spatial priors about myocardial shape as well as temporal priors about characteristic perfusion patterns. Different temporal and spatial features are developed without a strict need for temporal correspondence across the image sequences. We also investigate which combination of spatial and temporal features yields the best segmentation performance. Our evaluation criteria were boundary errors wrt manual segmentations, area overlap, and convergence envelope. From a quantitative evaluation on 19 perfusion studies, we conclude that a combination of the maximum intensity projection feature and gradient orientation map yields the best segmentation performance, with an average point-to-curve error of 0.9-1 pixel wrt manual contours. We also conclude that addition of different temporal features does not necessarily increase performance.MediamaticsElectrical Engineering, Mathematics and Computer Scienc