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Leptodactylus bufonius
Number of Pages: 22Integrative BiologyGeological Science
The structure of hypersonic shock waves using Navier-Stokes equations modified to include mass diffusion
Howard Brenner has recently proposed modifications to the Navier-Stokes
equations that relate to a diffusion of fluid volume that would be significant
for flows with high density gradients. In a previous paper (Greenshields &
Reese, 2007), we found these modifications gave good predictions of the viscous
structure of shock waves in argon in the range Mach 1.0-12.0 (while
conventional Navier-Stokes equations are known to fail above about Mach 2).
However, some areas of concern with this model were a somewhat arbitrary choice
of modelling coefficient, and potentially unphysical and unstable solutions. In
this paper, we therefore present slightly different modifications to include
molecule mass diffusion fully in the Navier-Stokes equations. These
modifications are shown to be stable and produce physical solutions to the
shock problem of a quality broadly similar to those from the family of extended
hydrodynamic models that includes the Burnett equations. The modifications
primarily add a diffusion term to the mass conservation equation, so are at
least as simple to solve as the Navier-Stokes equations; there are none of the
numerical implementation problems of conventional extended hydrodynamics
models, particularly in respect of boundary conditions. We recommend further
investigation and testing on a number of different benchmark non-equilibrium
flow cases.Comment: written for the 2nd European Conference on AeroSpace Sciences
(EUCASS), Belgium, 200
A systematic review and meta-analysis of Macroplastique for treating female stress urinary incontinence.
Introduction and hypothesisMacroplastique® (polydimethylsiloxane injection) is a minimally invasive urethral bulking agent with global clinical literature describing its use over 20 years. This study critically assessed the safety and effectiveness outcomes for adult women treated with Macroplastique for stress urinary incontinence (SUI) through a systematic review and meta-analysis.MethodsA systematic review of the scientific literature from 1990 to 2010 was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to quantitatively summarize the safety and effectiveness of Macroplastique for female SUI. A total of 958 patients from 23 cohorts were eligible for inclusion and were analyzed. Random-effects models were used to estimate the improvement and cure rates following treatment at three time periods: short-term (<6 months), mid-term (6-18 months), and long-term (>18 months). Expanded models assessed the effect of reinjection rate on successful treatment outcomes. Adverse event rates were aggregated and reported.ResultsImprovement rates were 75 % [95 % confidence interval (CI), 69-81] in the short-term, 73 % (95 % CI, 62-83) in the mid-term, and 64 % (95 % CI, 57-71) long-term. Cure/dry rates were 43 % (95 % CI, 33-54), 37 % (95 % CI, 28-46), and 36 % (95 % CI, 27-46) over the same respective follow-up periods. Higher study reinjection rates were associated with improved long-term SUI outcomes. No serious adverse events were reported.ConclusionsThis quantitative review supports Macroplastique as an effective, durable, and safe treatment option for female SUI. Meta-analytic evidence suggests that long-term therapeutic benefit is frequently maintained, with some patients requiring reinjection
Anal signs of child sexual abuse: a case–control study
Background:
There is uncertainty about the nature and specificity of physical signs following anal child sexual abuse. The study investigates the extent to which physical findings discriminate between children with and without a history of anal abuse.<p></p>
Methods:
Retrospective case note review in a paediatric forensic unit.<p></p>
Cases: all eligible cases from 1990 to 2007 alleging anal abuse.<p></p>
Controls: all children examined anally from 1998 to 2007 with possible physical abuse or neglect with no identified concern regarding sexual abuse. Fisher’s exact test (two-tailed) was performed to ascertain the significance of differences for individual signs between cases and controls. To explore the potential role of confounding, logistic regression was used to produce odds ratios adjusted for age and gender.<p></p>
Results:
A total of 184 cases (105 boys, 79 girls), average age 98.5 months (range 26 to 179) were compared with 179 controls (94 boys, 85 girls) average age 83.7 months (range 35–193). Of the cases 136 (74%) had one or more signs described in anal abuse, compared to 29 (16%) controls. 79 (43%) cases and 2 (1.1%) controls had >1 sign. Reflex anal dilatation (RAD) and venous congestion were seen in 22% and 36% of cases but <1% of controls (likelihood ratios (LR) 40, 60 respectively), anal fissure in 14% cases and 1.1% controls (LR 13), anal laxity in 27% cases and 3% controls (LR 10).<p></p>
Novel signs seen significantly more commonly in cases were anal fold changes, swelling and twitching. Erythema, swelling and fold changes were seen most commonly within 7 days of last reported contact; RAD, laxity, venous congestion, fissure and twitching were observed up to 6 months after the alleged assault.<p></p>
Conclusions:
Anal findings are more common in children alleging anal abuse than in those presenting with physical abuse or neglect with no concern about sexual abuse. Multiple signs are rare in controls and support disclosed anal abuse
The structure of shock waves as a test of Brenner's modifications to the Navier-Stokes equations
Brenner has recently proposed modifications to the Navier-Stokes equations
that are based on theoretical arguments but supported only by experiments
having a fairly limited range. These modifications relate to a diffusion of
fluid volume that would be significant for flows with high density gradients.
So the viscous structure of shock waves in gases should provide an excellent
test case for this new model. In this paper we detail the shock structure
problem and propose exponents for the gas viscosity-temperature relation based
on empirical viscosity data that is independent of shock experiments. We then
simulate shocks in the range Mach 1.0-12.0 using the Navier-Stokes equations,
both with and without Brenner's modifications. Initial simulations showed
Brenner's modifications display unphysical behaviour when the coefficient of
volume diffusion exceeds the kinematic viscosity. Our subsequent analyses
attribute this behaviour to both an instability to temporal disturbances and a
spurious phase velocity-frequency relationship. On equating the volume
diffusivity to the kinematic viscosity, however, we find the results with
Brenner's modifications are significantly better than those of the standard
Navier-Stokes equations, and broadly similar to those from the family of
extended hydrodynamic models that includes the Burnett equations. Brenner's
modifications add only two terms to the Navier-Stokes equations, and the
numerical implementation is much simpler than conventional extended
hydrodynamic models, particularly in respect of boundary conditions. We
recommend further investigation and testing on a number of different benchmark
non-equilibrium flow cases
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