Contribución para el estudio de los orígenes y evolución del psicoanálisis en Brasil

El psicoanálisis es una de las más importantes teorías psicológicas disponibles a la cultura y conocimiento humano, pero, sobre todo, tratase de una de las más poderosas herramientas de tratamiento para los disturbios mentales, para la obtención y el mantenimiento de la salud de las personas. Su desarrollo en Brasil ha sido obtenido, obviamente, con contornos distintos que de otros países. Este trabajo – una parte de un estudio longitudinal - es una pequeña contribución a otros esfuerzos de profesionales interesados en la comprensión del campo psicoanalítico Latinoamericano que no está, todavía, estudiado de manera articulada y, por lo tanto, suficientemente divulgada entre los investigadores interesados en abordar el tema.Eje temático: PsicoanálisisFacultad de Psicologí

Contribución para el estudio de los orígenes y evolución del psicoanálisis en Brasil

El psicoanálisis es una de las más importantes teorías psicológicas disponibles a la cultura y conocimiento humano, pero, sobre todo, tratase de una de las más poderosas herramientas de tratamiento para los disturbios mentales, para la obtención y el mantenimiento de la salud de las personas. Su desarrollo en Brasil ha sido obtenido, obviamente, con contornos distintos que de otros países. Este trabajo – una parte de un estudio longitudinal - es una pequeña contribución a otros esfuerzos de profesionales interesados en la comprensión del campo psicoanalítico Latinoamericano que no está, todavía, estudiado de manera articulada y, por lo tanto, suficientemente divulgada entre los investigadores interesados en abordar el tema.Eje temático: PsicoanálisisFacultad de Psicologí

Contribución para el estudio de los orígenes y evolución del psicoanálisis en Brasil

El psicoanálisis es una de las más importantes teorías psicológicas disponibles a la cultura y conocimiento humano, pero, sobre todo, tratase de una de las más poderosas herramientas de tratamiento para los disturbios mentales, para la obtención y el mantenimiento de la salud de las personas. Su desarrollo en Brasil ha sido obtenido, obviamente, con contornos distintos que de otros países. Este trabajo – una parte de un estudio longitudinal - es una pequeña contribución a otros esfuerzos de profesionales interesados en la comprensión del campo psicoanalítico Latinoamericano que no está, todavía, estudiado de manera articulada y, por lo tanto, suficientemente divulgada entre los investigadores interesados en abordar el tema.Eje temático: PsicoanálisisFacultad de Psicologí

An Environmental Science and Engineering Framework for Combating Antimicrobial Resistance

On June 20, 2017, members of the environmental engineering and science (EES) community convened at the Association of Environmental Engineering and Science Professors (AEESP) Biennial Conference for a workshop on antimicrobial resistance. With over 80 registered participants, discussion groups focused on the following topics: risk assessment, monitoring, wastewater treatment, agricultural systems, and synergies. In this study, we summarize the consensus among the workshop participants regarding the role of the EES community in understanding and mitigating the spread of antibiotic resistance via environmental pathways. Environmental scientists and engineers offer a unique and interdisciplinary perspective and expertise needed for engaging with other disciplines such as medicine, agriculture, and public health to effectively address important knowledge gaps with respect to the linkages between human activities, impacts to the environment, and human health risks. Recommendations that propose priorities for research within the EES community, as well as areas where interdisciplinary perspectives are needed, are highlighted. In particular, risk modeling and assessment, monitoring, and mass balance modeling can aid in the identification of “hot spots” for antibiotic resistance evolution and dissemination, and can help identify effective targets for mitigation. Such information will be essential for the development of an informed and effective policy aimed at preserving and protecting the efficacy of antibiotics for future generations

Low-Temperature Sintering of Alumina with Liquid-Forming Additives

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66046/1/j.1151-2916.1991.tb07825.x.pd

Factors that contribute to faecal cyclooxygenase-2 mRNA expression in subjects with colorectal cancer

浜松医科大学学位論文　医博第600号（平成23年3月16日

High Salt Intake Down-Regulates Colonic Mineralocorticoid Receptors, Epithelial Sodium Channels and 11β-Hydroxysteroid Dehydrogenase Type 2

Besides the kidneys, the gastrointestinal tract is the principal organ responsible for sodium homeostasis. For sodium transport across the cell membranes the epithelial sodium channel (ENaC) is of pivotal relevance. The ENaC is mainly regulated by mineralocorticoid receptor mediated actions. The MR activation by endogenous 11β-hydroxy-glucocorticoids is modulated by the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Here we present evidence for intestinal segment specific 11β-HSD2 expression and hypothesize that a high salt intake and/or uninephrectomy (UNX) affects colonic 11β-HSD2, MR and ENaC expression. The 11β-HSD2 activity was measured by means of 3H-corticosterone conversion into 3H-11-dehydrocorticosterone in Sprague Dawley rats on a normal and high salt diet. The activity increased steadily from the ileum to the distal colon by a factor of about 3, an observation in line with the relevance of the distal colon for sodium handling. High salt intake diminished mRNA and protein of 11β-HSD2 by about 50% (p<0.001) and reduced the expression of the MR (p<0.01). The functionally relevant ENaC-β and ENaC-γ expression, a measure of mineralocorticoid action, diminished by more than 50% by high salt intake (p<0.001). The observed changes were present in rats with and without UNX. Thus, colonic epithelial cells appear to contribute to the protective armamentarium of the mammalian body against salt overload, a mechanism not modulated by UNX

Comparative Analyses Define Differences Between Bhd-Associated Renal Tumour and Sporadic Chromophobe Renal Cell Carcinoma

BACKGROUND: Birt-Hogg-Dubé (BHD) syndrome, caused by germline alteration of folliculin (FLCN) gene, develops hybrid oncocytic/chromophobe tumour (HOCT) and chromophobe renal cell carcinoma (ChRCC), whereas sporadic ChRCC does not harbor FLCN alteration. To date, molecular characteristics of these similar histological types of tumours have been incompletely elucidated. METHODS: To elucidate renal tumourigenesis of BHD-associated renal tumours and sporadic renal tumours, we conducted whole genome sequencing (WGS) and RNA-sequencing (RNA-seq) of sixteen BHD-associated renal tumours from nine unrelated BHD patients, twenty-one sporadic ChRCCs and seven sporadic oncocytomas. We then compared somatic mutation profiles with FLCN variants and RNA expression profiles between BHD-associated renal tumours and sporadic renal tumours. FINDINGS: RNA-seq analysis revealed that BHD-associated renal tumours and sporadic renal tumours have totally different expression profiles. Sporadic ChRCCs were clustered into two distinct clusters characterized by L1CAM and FOXI1 expressions, molecular markers for renal tubule subclasses. Increased mitochondrial DNA (mtDNA) copy number with fewer variants was observed in BHD-associated renal tumours compared to sporadic ChRCCs. Cell-of-origin analysis using WGS data demonstrated that BHD-associated renal tumours and sporadic ChRCCs may arise from different cells of origin and second hit FLCN alterations may occur in early third decade of life in BHD patients. INTERPRETATION: These data further our understanding of renal tumourigenesis of these two different types of renal tumours with similar histology. FUNDING: This study was supported by JSPS KAKENHI Grants, RIKEN internal grant, and the Intramural Research Program of the National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research