Evaluation of Agreement between HRT III and iVue OCT in Glaucoma and Ocular Hypertension Patients

Purpose. To determine the agreement between Moorfields Regression Analysis (MRA), Glaucoma Probability Score (GPS) of Heidelberg retinal tomograph (HRT III), and peripapillary nerve fibers thickness by iVue Optical Coherence Tomography (OCT). Methods. 72 eyes with ocular hypertension or primary open angle glaucoma (POAG) were included in the study: 54 eyes had normal visual fields (VF) and 18 had VF damage. All subjects performed achromatic 30° VF by Octopus Program G1X dynamic strategy and were imaged with HRT III and iVue OCT. Sectorial and global MRA, GPS, and OCT parameters were used for the analysis. Kappa statistic was used to assess the agreement between methods. Results. A significant agreement between iVue OCT and GPS for the inferotemporal quadrant (κ: 0.555) was found in patients with abnormal VF. A good overall agreement between GPS and MRA was found in all the eyes tested (κ: 0.511). A good agreement between iVue OCT and MRA was shown in the superonasal (κ: 0.656) and nasal (κ: 0.627) quadrants followed by the superotemporal (κ: 0.602) and inferotemporal (κ: 0.586) sectors in all the studied eyes. Conclusion. The highest percentages of agreement were found per quadrant of the MRA and the iVue OCT confirming that in glaucoma damage starts from the temporal hemiretina

Moorfield regression analysis versus retinal nerve fiber layer in glaucoma and ocular hypertension

Purpose: To evaluate the agreement between Moorfield Regression Analysis (MRA) and peripapillary retinal nerve fibers layer thickness. Methods: 54 eyes with normal VF and 18 with early VF damage were classified as ocular hypertension or early primary open angle glaucoma (POAG) and were included in the study: All the subjects performed achromatic 30\ub0 visual field (VF) by Octopus Program G1X dynamic strategy and were imaged by HRT 3 and I-Vue OCT. Sectorial and global MRA and OCT parameters were used for the analysis. Kappa statistic was used to assess the agreement between methods. Results: A significant agreement between I-Vue OCT and MRA a good agreement was shown in the supero-nasal (\u3ba 0.656) and nasal (\u3ba 0.627) quadrants followed by the supero-temporal (\u3ba 0.602) and inferotemporal (\u3ba 0.586) sectors in all the eyes studied. Conclusion: Our results suggest that the measurements of the ganglion cells by HRT 3 and I-Vue OCT are not interchangeable

Evaluation of Agreement between HRT III and iVue OCT in Glaucoma and Ocular Hypertension Patients

. Purpose. To determine the agreement between Moorfields Regression Analysis (MRA), Glaucoma Probability Score (GPS) of Heidelberg retinal tomograph (HRT III), and peripapillary nerve fibers thickness by iVue Optical Coherence Tomography (OCT). Methods. 72 eyes with ocular hypertension or primary open angle glaucoma (POAG) were included in the study: 54 eyes had normal visual fields (VF) and 18 had VF damage. All subjects performed achromatic 30 ∘ VF by Octopus Program G1X dynamic strategy and were imaged with HRT III and iVue OCT. Sectorial and global MRA, GPS, and OCT parameters were used for the analysis. Kappa statistic was used to assess the agreement between methods. Results. A significant agreement between iVue OCT and GPS for the inferotemporal quadrant ( : 0.555) was found in patients with abnormal VF. A good overall agreement between GPS and MRA was found in all the eyes tested ( : 0.511). A good agreement between iVue OCT and MRA was shown in the superonasal ( : 0.656) and nasal ( : 0.627) quadrants followed by the superotemporal ( : 0.602) and inferotemporal ( : 0.586) sectors in all the studied eyes. Conclusion. The highest percentages of agreement were found per quadrant of the MRA and the iVue OCT confirming that in glaucoma damage starts from the temporal hemiretina

Ganglion cell complex evaluation in exudative age-related macular degeneration after repeated intravitreal injections of ranibizumab

Purpose. To detect the effects of intravitreal ranibizumab injections on GCC in patients with wet AMD. Methods. 32 wet AMD eyes were selected and submitted at three ranibizumab injections. RTVue-OCT GCC and MM5 protocol were performed before treatment and twenty days after each injection. Results. At baseline mean GCC thickness was 93.9 ± 18.5 μm. Twenty days after each intravitreal injection it was, respectively, 85.8 ± 10.1, 86.5 ± 9.3, and 91.1 ± 11.5 μm, without statistical significance. A significant improvement in visual acuity (P = 0.031) and a reduction of mean foveal (P = 0.001) and macular thickness (P = 0.001) were observed. Conclusion. The clinical results confirm therapeutic efficacy of intravitreal injections of ranibizumab in wet AMD. A contemporary not statistically significant reduction of GCC thickness suggests that the loading phase of ranibizumab does not have any toxic effects on ganglion cell complex