Разработка налоговой политики МУП «КРУ г.Юрги»

Объектом исследования является муниципальное унитарное предприятие "Комбинат ритуальных услуг г. Юрги". Цель работы – формирования налоговой политики муниципального унитарного предприятия "Комбинат ритуальных услуг г. Юрги". Актуальность работы определяется критическим влиянием налоговой политики на финансово-хозяйственную деятельность предприятия и повышение эффективности управления его налоговыми потоками. Для достижения поставленной цели решены следующие задачи: 1.Рассмотреть теоретическую базу проведения налогового анализа на микроуровне. 2.Выполнить анализ финансово-хозяйственной деятельности МУП КРУ г. Юрги. 3.Оценить влияние налоговых платежей на финансовый результат деятельности МУП КРУ г. Юрги. 4.Предложить рекомендации по оптимизации налоговых выплат.The purpose of the work is the formation of the tax policy of the municipal unitary enterprise "Combine of funeral services of Yurga". The relevance of the work is determined by the critical impact of tax policy on the financial and economic activities of the enterprise and improving the efficiency of managing its tax flows. To achieve this goal, the following tasks were solved: 1. Consider the theoretical basis for conducting tax analysis at the micro level. 2. To analyze the financial and economic activities of the municipal unitary enterprise of the switchgear of the city of Yurga. 3. To assess the impact of tax payments on the financial result of the activities of the municipal unitary enterprise of KRU of Yurga 4. To offer recommendations for optimizing tax payments

Molecular cloning, expression and regulation of the avian tubby-like protein 1 (tulp1) gene

The tubby-like protein 1 (tulp1) gene is a member of the tubby multigene family which includes tub, tulp1, tulp2 and tulp3. Human and mouse tulp1 genes were cloned and mutations in tulp1 have been implicated in retinitis pigmentosa in man. Here we report on the cDNA cloning of the chicken tulp1 homologue and its protein product deduced from the nucleotide sequence. The chicken Tulp1 protein comprises 358 amino acids with a calculated molecular mass of 40 kDa. The overall structure of Tub and Tulp proteins, exemplified by the highly conserved C-terminal domain of 255 amino acids and the signature motif KLACE, is also preserved in chicken Tulp1. Phylogenetic analysis demonstrates that chicken tulp1 cDNA and protein are closely related to human and mouse tulp1. In addition, chicken tulp1 mRNA is abundantly expressed in retina similar to tulp1 expression in human and mouse. Two tulp1-specific transcripts of 2 and 3 kb in size were identified that showed differential regulation during embryonic and postnatal development. Finally, tulp1 mRNA was found to be expressed in chicken erythroid cells and upregulated by ligand-activated thyroid hormone receptor (TRα/c-erbA)

Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by mimicking amino acid (AA) supply from a casein-based diet, we demonstrate that restriction of dietary essential AA (EAA), but not non-EAA, drives the systemic metabolic response to total AA deprivation; independent from dietary carbohydrate supply. Furthermore, systemic deprivation of threonine and tryptophan, independent of total AA supply, are both adequate and necessary to confer the systemic metabolic response to both diet, and genetic AA-transport loss, driven AA restriction. Dietary threonine restriction (DTR) retards the development of obesity-associated metabolic dysfunction. Liver-derived fibroblast growth factor 21 is required for the metabolic remodelling with DTR. Strikingly, hepatocyte-selective establishment of threonine biosynthetic capacity reverses the systemic metabolic response to DTR. Taken together, our studies of mice demonstrate that the restriction of EAA are sufficient and necessary to confer the systemic metabolic effects of DPD