The effect of incubation temperature on the specificity of the BANA (N-benzoyl-DL-arginine-naphthylamide) test

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75429/1/j.1399-302X.1993.tb00544.x.pd

Kitozanski umetci za periodontitis: Utjecaj količine lijeka, plastifikatora i umrežavanja na oslobađanje metronidazola in vitro

Chitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole loading and in vitro metronidazole release kinetics. The fabricated inserts exhibited satisfactory physical characteristics. The mass of inserts was in the range of 5.63 ± 0.42 to 6.04 ± 0.89 mg. The thickness ranged from 0.46 ± 0.06 to 0.49 ± 0.08 mm. Metronidazole loading was in the range of 0.98 ± 0.09 to 1.07 ± 0.07 mg except for batch CM3 with MZ loading of 2.01 ± 0.08 mg. The inserts exhibited an initial burst release at the end of 24 h, irrespective of the drug to polymer ratio, plasticizer content or cross-linking. However, further drug release was sustained over the next 6 days. Cross-linking with 10% (m/m) of glutaraldehyde inhibited the burst release by ~30% and increased the mean dissolution time (MDT) from 0.67 to 8.59 days. The decrease in drug release was a result of reduced permeability of chitosan due to cross-linking.Umetci metronidazola na bazi kitozana napravljeni su kasting metodom. Proučavana je ujednačenost mase i debljine, količina ljekovite tvari i kinetika oslobađanja metronidazola in vitro. Fizičke karakteristike umetaka bile su zadovoljavajuće: masa je bila u rasponu 5,63 ± 0,42 – 6,04 ± 0,89 mg, debljina od 0.46 ± 0.06 – 0.49 ± 0.08 mm with, količina metronidazola od 0,98 ± 0,09 – 1,07 ± 0,07 mg. Nakon 24 h iz svih umetaka, neovisno o omjeru ljekovite tvari i polimera, količini plastifikatora ili umrežavanju, dio metronidazola se naglo oslobodio. Međutim, daljnje oslobađanje je bilo polagano tijekom 6 dana. Umrežavanje s 10% (m/m) otopinom glutaraldehida spriječilo je naglo oslobađanje za ~30% i povećalo je srednje vrijeme oslobađanja (MDT) s 0,67 na 8,59 dana. Smanjenje u oslobađanju ljekovite tvari posljedica je smanjenja permeabilnosti umreženog kitozana

Scanning electron microscope study of 48-hour plaque on different bridge pontics designs.

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Efficacité d’insecticides contre Scaphoideus titanus en vignobles biologiques et effets secondaires

La flavescence dorée de la vigne et la lutte obligatoire contre son vecteur Scaphoideus titanus posent d’importants problèmes dans les vignobles conduits en culture biologique. Afin de développer une stratégie de lutte basée sur des insecticides compatibles avec la viticulture biologique, des essais en plein champ ont été conduits au Tessin en 2006-2007. Le Parexan N (pyréthrine + huile de sésame) s’est avéré le seul produit biologique efficace à plus de 90% contre les formes immatures de S. titanus, par contre il n’a eu aucun effet contre les adultes. L’application répétée de Parexan N s’est montrée toxique pour les typhlodromes de l’espèce Amblyseius andersoni. Malgré cette toxicité, la seule stratégie de lutte efficace et recommandée dans les vignobles biologique consiste en trois applications de Parexan N à un intervalle de dix jours dès l’apparition des premiers individus du 3e stade larvaire

The CropSyst model to simulate the N balance of rice for alternative management

CropSyst is a mechanistic model developed for simulating the growth and development of potentially all herbaceous crops under potential and water/nitrogen (N)-limited conditions. Although the model has been widely used for many crops under different pedo-climatic and management conditions, studies on the simulation of water and N balance for flooded rice are lacking. We evaluated the CropSyst model for simulating the N balance of north-Italian rice fields for scatter-seeded rice grown under continuously flooded conditions. In order to calibrate and validate the model for the processes involved with soil N transformation, data collected in field experiments carried out in northern Italy between 2002 and 2004 were used. The results show the robustness of the model in reproducing the course of the measured soil mineral nitrogen content: the Modeling Efficiencies which describe the agreement between measured and simulated trends, are in most cases positive and the model error fell almost always within the experimental error on the measurements (P = 0.95). Moreover, the model showed the same level of reliability while simulating the nitrogen balances under different levels of nitrogen fertilization, thus depicting it as suitable for comparing N fertilization scenarios. This first attempt at using a model for simulating the nitrogen balance under flooded conditions encourages further studies because of the need of effective tools for optimizing the nitrogen management of flooded rice systems, considered significant sources of groundwater pollution and greenhouse gases in many European rice districts