5,651 research outputs found

    Mr. Presidential Candidate: Whom Would You Nominate?

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    Presidential candidates compete on multiple fronts for votes. Who is more likeable? Who will negotiate more effectively with allies and adversaries? Who has the better vice-presidential running mate? Who will make better appointments to the Supreme Court and the cabinet? This last question is often discussed long before the inauguration, for the impact of a secretary of state or a Supreme Court justice can be tremendous. Despite the importance of such appointments, we do not expect candidates to compete on naming the better slates of nominees. For the candidates themselves, avoiding competition over nominees in the pre-election context has personal benefits—in particular, enabling them to keep a variety of supporters working hard on the campaign in the hope of being chosen as nominees. But from a social perspective, this norm has costs. This Article proposes that candidates be induced out of the status quo. In the current era of candidates responding to internet queries and members of the public asking questions via YouTube, it is plausible that the question—“Whom would you nominate (as secretary of state or for the Supreme Court)?”—might be asked in a public setting. If one candidate is behind in the race, he can be pushed to answer the question—and perhaps increase his chances of winning the election

    Centripetal Forces in China's Economic Takeoff

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    This paper uses provincial time series data from the People's Republic of China to empirically investigate two propositions relating to economic development: (i) that economic takeoff--or an acceleration in economic growth--is associated with inflows of foreign direct investment (FDI), possibly through technological transfer; and (ii) that takeoff is accompanied, at least in the short term, by widening income inequality. The results indicate that FDI flows have increased the rate of convergence in per capita incomes across China's provinces. However, the pattern of FDI, which has gone mainly to the relatively wealthy provinces, has caused different provinces to converge toward different steady states. . Copyright 2002, International Monetary Fund

    Assessment of the Stock of Threadfin Bream (Nemipterus japonicus) in the Northwest Continental Shelf of India

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    The maximum sustainable yields of N. japonicus and all-demersal fish from the northwest continental shelf are estimated to be 136,975 tons and 1,056246 tons respectively. The standing stock of N. japonicus in the Kamataka shelf is 38,621 tons. which is about 27.7% of the standing stock of all demersal species

    Morphometry and biology of the duskyshark, Carcharhinus obscurus (Lesueur), from the oceanic region off the West Coast of India

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    The correlation co-efficient (r) for the regression of various morphometric characteristics on total length ranged from 0.736 for the second dorsal (02 ) base to 0.997 for the standard length from snout to origin of dorsal Ic)be of caudal. The length (total) at birth ranges from 69 cm to 102 cm. The lengths at the age of 1, 10,20 and 30 years were estimated to be 102 cm, 269 cm, 341 cm and 366 cm respectively. The total life span is about 30 years

    Assessment of Saurida tumbil (Bloch) stock in the northwest continental shelf water of India

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    Based on the data collected from New Ferry Wharf, Sassoon Dock and exploratory survey of MFV Saraswati on the Northwest coast of India, the growth, mortality, population and stock parameters of Saurida tumbil is reported in the present communication. The Von Bertalanffy growth function (GF) parameters for growth on length were found to be L∞=49.8 cm, K=0.96/year, t0 = -.141 year. The length at recruitment (lr) is 80 mm. (tr=.167 year) while the length at first capture (lc) for the commercial trawl fishery is 100 mm (tc=0.25 year). The annual fishing mortality coefficient (F) for 1983-85 was 0.43, the natural mortality coefficient (M) was 1.33 and the exploitation ratio (E) was 0.25. The yield per recruit (Y/R) attained the maximum of 54.99 g at F=1.091 for E=0.45 for the present tc at 0.25 year. The annual total stock (P) and standing stock (P) in the exploitation portion at the inshore grounds to a depth of about 50 m were estimated to be 12,811 tons and 6,034 tons respectively. The average annual yield of 2,635 tons at the present F=0.439 (E=0.247) was less than the maximum sustainable yield (MSY) for 3,331 tons attainable from the inshore grounds at E=0.45

    Stock assessment of soldier catfish Osteogeneiosus militaris along the northwest coast of India

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    Value of length growth parameters L∞, K and t(sub)0 from age-length relation obtained from length-frequency analysis for the soldier catfish stock were estimated to be 47.6 cm, 0.51 per year and 0.03 year respectively. The age at recruitment (t [sub]r) was 0.58 year and the age at first capture (t[sub]c) 0.83 year. The total mortality (Z) was 0.88 including the present natural mortality (M) of 0.84 and fishing mortality (F) of 0.04. The total stock of this fish along the Northwest coast of India was assessed to be 32,413 tons and the MSY 5,426 tons which is much higher than the current catch of 863.8 tons. The potential yield (P[sub]y) of 38.7 g per recruit could be obtained at the optimum of exploitation (t[sub]y) of 2.84 years

    Obstetrics and Gynecological History

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    Atherosclerotic cardiovascular disease (ASCVD) remains a significant cause of morbidity and mortality in women, with event rates rising particularly in young women. Women are disproportionately affected by traditional cardiovascular (CV) risk factors such as diabetes and hypertension compared with men. In addition to standard risk factors, many risk factors are either female predominant, such as autoimmune conditions and psychological stressors, or female specific, such as hormonal changes, throughout the course of a lifetime and pregnancy-related issues. Among the most important risk factors specific to women are conditions occurring during pregnancy and history related to fertility and gynecological conditions. The value of such history has become more apparent in recent literature; however, the translation of this knowledge to clinical practice has been poor. The importance of recognizing specific obstetric and gynecological (OB-GYN) conditions and the specific conditions to screen for are the focus of this editorial

    Drafting a model collective action clause for eurozone sovereign bonds

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    Receptor binding specificity of recent human H3N2 influenza viruses

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    <p>Abstract</p> <p>Background</p> <p>Human influenza viruses are known to bind to sialic acid linked α2-6 to galactose, but the binding specificity beyond that linkage has not been systematically examined. H3N2 human influenza isolates lost binding to chicken red cells in the 1990s but viruses isolated since 2003 have re-acquired the ability to agglutinate chicken erythrocytes. We have investigated specificity of binding, changes in hemagglutinin sequence of the recent viruses and the role of sialic acid in productive infection.</p> <p>Results</p> <p>Viruses that agglutinate, or do not agglutinate, chicken red cells show identical binding to a Glycan Array of 264 oligosaccharides, binding exclusively to a subset of α2-6-sialylsaccharides. We identified an amino acid change in hemagglutinin that seemed to correlate with chicken red cell binding but when tested by mutagenesis there was no effect. Recombinant hemagglutinins expressed on Sf-9 cells bound chicken red cells but the released recombinant baculoviruses agglutinated only human red cells. Similarly, an isolate that does not agglutinate chicken red cells show hemadsorption of chicken red cells to infected MDCK cells. We suggest that binding of chicken red cells to cell surface hemagglutinin but not to virions is due to a more favorable hemagglutinin density on the cell surface. We investigated whether a virus specific for α2-6 sialyloligosaccharides shows differential entry into cells that have varying proportions of α2-6 and α2-3 sialic acids, including human A549 and HeLa cells with high levels of α2-6 sialic acid, and CHO cells that have only α2-3 sialic acid. We found that the virus enters all cell types tested and synthesizes viral nucleoprotein, localized in the nucleus, and hemagglutinin, transported to the cell surface, but infectious progeny viruses were released only from MDCK cells.</p> <p>Conclusion</p> <p>Agglutination of chicken red cells does not correlate with altered binding to any oligosaccharide on the Glycan Array, and may result from increased avidity due to density of hemagglutinin and not increased affinity. Absence of α2-6 sialic acid does not protect a cell from influenza infection and the presence of high levels of α2-6-sialic acids on a cell surface does not guarantee productive replication of a virus with α2-6 receptor specificity.</p
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