Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases

Soil-transmitted helminth infections represent a large burden with over a quarter of the world's population at risk. Low cure rates are observed with standard of care (albendazole); therefore, a more effective combination therapy (albendazole and ivermectin) is being investigated but showed variable treatment efficacies without evidence of intrinsic parasite resistance. Here, we analyzed the microbiome of Trichuris trichiura and hookworm-infected patients and found an association of different enterotypes with treatment efficacy. 80 T. trichiura-infected patients with hookworm co-infections from Pak-Khan, Laos, received either albendazole (n = 41) or albendazole and ivermectin combination therapy (n = 39). Pre-/post-treatment stool samples were collected to monitor treatment efficacy and microbial communities were profiled using 16S rRNA gene sequencing, qPCR, and shotgun sequencing. We identified three bacterial enterotypes and show that pre-treatment enterotype is associated with efficacy of the combination treatment for both T. trichiura (CRET1 = 5.8%; CRET2 = 16.6%; CRET3 = 68.8%) and hookworm (CRET1 = 31.3%; CRET2 = 16.6%; CRET3 = 78.6%). This study shows that pre-treatment enterotype enables predicting treatment outcome of combination therapy for T. trichiura and hookworm infections.Trial registration: ClinicalTrials.gov, NCT03527732. Registered 17 May 2018, https://clinicaltrials.gov/ct2/show/NCT03527732

Receiver design for the REACH global 21-cm signal experiment

We detail the the REACH radiometric system designed to enable measurements of the 21-cm neutral hydrogen line. Included is the radiometer architecture and end-to-end system simulations as well as a discussion of the challenges intrinsic to highly-calibratable system development. Following this, we share laboratory results based on the calculation of noise wave parameters utilising an over-constrained least squares approach demonstrating a calibration RMSE of 80 mK for five hours of integration on a custom-made source with comparable impedance to that of the antenna used in the field. This paper therefore documents the state of the calibrator and data analysis in December 2022 in Cambridge before shipping to South Africa.Comment: 30 pages, 19 figure

Backtracking and Mixing Rate of Diffusion on Uncorrelated Temporal Networks

We consider the problem of diffusion on temporal networks, where the dynamics of each edge is modelled by an independent renewal process. Despite the apparent simplicity of the model, the trajectories of a random walker exhibit non-trivial properties. Here, we quantify the walker's tendency to backtrack at each step (return where he/she comes from), as well as the resulting effect on the mixing rate of the process. As we show through empirical data, non-Poisson dynamics may significantly slow down diffusion due to backtracking, by a mechanism intrinsically different from the standard bus paradox and related temporal mechanisms. We conclude by discussing the implications of our work for the interpretation of results generated by null models of temporal networks

Accurate distance measurement by an autonomous ultrasonic system combining time-of-flight and phase-shift methods

This paper presents an efficient algorithm for distance measurement, combining both the pulse time-of-flight method and the CW phase-shift method. It copes with a low-rate sampling technique allowed by the limited bandwidth of two ultrasonic transducers working in air at 30 kHz and with modest software resources of autonomous devices. The measuring system was implemented and tested on a compact Motorola MC68HC16-based platform, with a minimum of attached hardware. Experimental results show an accuracy better than 1 mm for a poor reflecting target at a distance of about 1 m

Random walk on temporal networks with lasting edges

We consider random walks on dynamical networks where edges appear and disappear during finite time intervals. The process is grounded on three independent stochastic processes determining the walker's waiting time, the up time, and the down time of the edges. We first propose a comprehensive analytical and numerical treatment on directed acyclic graphs. Once cycles are allowed in the network, non-Markovian trajectories may emerge, remarkably even if the walker and the evolution of the network edges are governed by memoryless Poisson processes. We then introduce a general analytical framework to characterize such non-Markovian walks and validate our findings with numerical simulations

Temporal pattern of (re)tweets reveal cascade migration

Twitter has recently become one of the most popular online social networking websites where users can share news and ideas through messages in the form of tweets. As a tweet gets retweeted from user to user, large cascades of information diffusion are formed over the Twitter follower network. Existing works on cascades have mainly focused on predicting their popularity in terms of size. In this paper, we leverage on the temporal pattern of retweets to model the diffusion dynamics of a cascade. Notably, retweet cascades provide two complementary information: (a) inter-retweet time intervals of retweets, and (b) diffusion of cascade over the underlying follower network. Using datasets from Twitter, we identify two types of cascades based on presence or absence of early peaks in their sequence of inter-retweet intervals. We identify multiple diffusion localities associated with a cascade as it propagates over the network. Our studies reveal the transition of a cascade to a new locality facilitated by pivotal users that are highly cascade dependent following saturation of current locality. We propose an analytical model to show co-occurrence of first peaks and cascade migration to a new locality as well as predict locality saturation from inter-retweet intervals. Finally, we validate these claims from empirical data showing co-occurrence of first peaks and migration with good accuracy; we obtain even better accuracy for successfully classifying saturated and non-saturated diffusion localities from inter-retweet intervals

Rock-paper-scissors dynamics from random walks on temporal multiplex networks

We study diffusion on a multiplex network where the contact dynamics between the nodes is governed by a random process and where the waiting-time distribution differs for edges from different layers. We study the impact on a random walk of the competition that naturally emerges between the edges of the different layers. In opposition to previous studies, which have imposed a priori inter-layer competition, the competition is here induced by the heterogeneity of the activity on the different layers. We first study the precedence relation between different edges and by extension between different layers, and show that it determines biased paths for the walker. We also discuss the emergence of cyclic, rock–paper–scissors effects on random walks, when the precedence between layers is non-transitive. Finally, we numerically show the slowing-down effect due to the competition on a multiplex network with heterogeneous layers activity as the walker is likely to be trapped for a longer time either on a single layer, or on an oriented cycle