Globular cluster population of the HST frontier fields galaxy J07173724+3744224

We present the first measurement of the globular cluster population surrounding the elliptical galaxy J07173724+3744224 (z=0.1546). This galaxy is located in the foreground in the field-of-view of the Hubble Space Telescope (HST) Frontier Fields observations of galaxy cluster MACS J0717.5+3745 (z=0.5458). Based on deep HST ACS F435W, F606W, and F814W images, we find a total globular cluster population of N_tot = 3441 +/- 1416. Applying the appropriate extinction correction and filter transformation from ACS F814W to the Johnson V-band, we determine that the host galaxy has an absolute magnitude of M_V = -22.2. The specific frequency was found to be S_N = 4.5 +/- 1.8. The radial profile of the globular cluster system was best fit using a powerlaw of the form $\sigma\sim R^{-0.6}$, with the globular cluster population found to be more extended than the halo light of the host galaxy ($\sigma_{halo}\sim R^{-1.7}$). The F435W-F814W colour distribution suggests a bimodal population, with red globular clusters 1-3x more abundant than blue clusters. These results are consistent with the host elliptical galaxy J07173724+3744224 having formed its red metal-rich GCs in situ, with the blue metal-poor globular clusters accreted from low-mass galaxies.Comment: 21 pages, 14 figures, 2 tables, revised following peer-review, accepted for publication in MNRA

The Role of Nano-Technology in Sustainable Construction: A Case Study of Using Nano Granite Waste Particles in Cement Mortar

Better understanding of the properties of cement-based materials, one of the most widely used building materials, at the nano-scale is crucial to improve its functionality in the built environment. This paper presents areas of using nano-materials in improving the characteristics of cement-based materials as well as introducing a new role of nano-technology together with waste management in enhancing the concept of sustainable construction. A case study on the use of nano-granite waste particles as a replacement of cement and fine aggregate in mortar production is presented. The research concluded that replacing 5% cement and 10% sand with nano-granite waste in the mortar mix increased the compressive strength of the green mortar by 41% compared to that of the control mix (CM). SEM images reinforced this result as the green mortar mix showed maximum density and minimum micro cracks and number of pores. A comparative study between the green mortar and traditional mortar was carried out using sustainability indicators to examine the environmental, social and economic implications. The environmental and social attributes showed a saving of 10% in the field of resource consumption, whereas savings in energy consumption and CO2 emissions reached 5%. The economic field showed saving of 6.5% indicating promising results in enhancing the sustainable construction industry

Cow’s milk protein elimination in autistic children: language, cognitive and behavioral outcome

Background: Behavioral modification and structured education are necessary in autism but rather insufficient. Various dietary restrictions have been suggested as important prerequisites to benefit from other interventions in this disorder. Objective: This study was designed to highlight the degree of benefit in various aspects of development of autistic children upon elimination of cow's milk protein (CMP) from their diet and assess the level of specific IgE for CMP in their sera. Methods: The current study was conducted on 22 autistic children who were compared to 30 age and sex matched healthy children. Enrolled autistic children were randomly assigned to one of two groups. The parents of first group were instructed to eliminate cow milk (CM) from the diet of their children throughout the study period while patients of the second group were allowed to eat without restrictions. Each enrolled child was subjected to complete dietetic history taking, clinical examination and measurement of IgE for CM antigen in their sera by enzyme immunoassay. Autistic patients underwent a Childhood Autism Rating Scale (CARS) test. The patients were also subjected to language and intelligent quotient (IQ) testing, social and mental age assessment and child psychiatric evaluation. The autistic children received an interventional program for six months and were then re-evaluated using the previous clinical parameters. Results: The first group achieved significantly lower CARS test results (p < 0.01), significantly higher language age (p < 0.05) and significantly higher rate of change of CARS, language, social age, mental age and IQ (p < 0.001, <0.05, <0.05, <0.01 and <0.05 respectively) compared to the second group after 6 months of follow up. There was also a significantly higher mean specific IgE level to CMP in the autistic patients as compared to the controls. Additionally, 45.5% of patients who were on CM elimination diet went one CARS category down compared to only 36.4% of the second group. Conclusion: We report improvement in language, cognition and behavioral capabilities upon CM elimination in a group of autistic children. The higher CM specific IgE in these children may suggest that such adverse reaction to CM may have an allergic basis. Wider scale studies are needed to justify this adjuvant therapeutic option in autistic children hoping for better achievement from the current interventional programs. Keywords: Allergy – Autism – CARS – Cow milk – IgE – IQEgypt J Pediatr Allergy Immunol 2006; 4(1): 15-2

Role of MRP-1 and GST-Pi in MDR and their inhibition by indomethacin in AML

Background: MDR continues to be a major challenge to effective chemotherapeutic interventions against cancer. Defining major factor contributing to MDR and inhibiting their action may thus be used for reversing MDR.Aim: This work aimed to evaluate the role played by MRP-1 and GST-Pi in MDR, and to explore the possible role of indomethacin as an inhibitor of chemotherapy resistance in patients with AML.Subjects and methods: The study included 2 groups, one included 20 healthy volunteers and the second included 50 AML patients. All patients received one cycle of standard induction chemotherapy, then regrouped according to their response to either CR group or unremitted group. Unremitted patients received a second cycle of chemotherapy combined with indomethacin. From each subject a blood sample was drawn before and after the 1st cycle of chemotherapy and after the 2nd cycle. From blood, mononuclear cells were separated, mRNA was extracted, and RT-PCR was carried out to detect GST-Pi and MRP-1 gene expression.Results: GST-Pi expression in CR group was 60% before therapy that significantly decreased to 30% after therapy. While in unremitted group, its expression significantly increased from 30% before to 80% after therapy. GST-Pi positive patients had a significantly lower overall and disease free survival time than GST Pi negative patients (P = 0.000 and 0.039, respectively). While MRP-1 expression was so low (20%) and remained unchanged after therapy in both groups. MRP-1 expression did not affect overall or disease free survival. Taking indomethacin with 2nd cycle of chemotherapy in unremitted patients resulted in a significant inhibition of GST-Pi expression and a significantly longer overall survival time than those taking 2nd cycle chemotherapy alone (P =0.034).Conclusion: MRP-1 is not likely to contribute to MDR, while GST-Pi might have a role in MDR phenotype in AML patients. Furthermore, GST-Pi inhibition significantly reduced MDR in AML patients.Keywords: AML; MDR; GST-Pi; MRP-1; Indomethacin; RT-PC

Research Weaving: Visualizing the Future of Research Synthesis

We propose a new framework for research synthesis of both evidence and influence, named research weaving. It summarizes and visualizes information content, history, and networks among a collection of documents on any given topic. Research weaving achieves this feat by combining the power of two methods: systematic mapping and bibliometrics. Systematic mapping provides a snapshot of the current state of knowledge, identifying areas needing more research attention and those ready for full synthesis. Bibliometrics enables researchers to see how pieces of evidence are connected, revealing the structure and development of a field. We explain how researchers can use some or all of these tools to gain a deeper, more nuanced understanding of the scientific literature

Determination of protein content in cooked foods consumed by toddlers aged 1-2 years in Sri Lanka

In early life, protein deficiency as well as heavy protein intake cause adverse conditions. Therefore, the present study aimed to assess the protein adequacy of diets in 1-2-year-old toddlers in the Alawwa Medical Officer of Health (MOH) area, Kurunegala, Sri Lanka. Data on food consumption was obtained by 24-hour dietary recall method from selected caregivers (n=60) andcommonly consumed foods (n=30) were cooked using household preparation protocols practiced in the area. They were homogenized and analyzed for protein. The majority of toddlers among the selected population consumed rice-based meals (73%) as the main meal (cooked rice with vegetable accompaniments), while 27% preferred mixed diets (a mixture of vegetables, pulses, leafy vegetables and fish along with rice). A serving of commercial cereal products provided the highest estimateddaily intake (EDI) of protein (10.70 ± 0.40 g). The average EDI of protein of all categories of foods per portion (rice, vegetables, pulses, green leaves, fish, eggs, rice mixtures and cereal products) was 31.55 ± 0.88 g, contributing to the recommended dietary allowance (RDA) of 242.64% and 150.17% for 1-2 year toddlers as defined by the Department of Agriculture, United States (USDA) and Sri Lankan RDA defined by Medical Research Institute (MRI), respectively. In conclusion, the cooked foods prepared according to local recipes fulfilled the dietary requirements of protein for toddlers aged 1-2 years in the Alawwa MOH area following USDA and Sri Lankan nutrition guidelines. Keywords: Estimated Daily Intake, Protein, Recommended Dietary Allowance, Toddler

Epidemiology, Clinical Manifestations, and Long-Term Outcomes of a Major Outbreak of Chikungunya in a Hamlet in Sri Lanka, in 2007: A Longitudinal Cohort Study

Chikungunya outbreaks occurred in the central province, Sri Lanka in 2006. This community-based study reports the epidemiology and the natural history of the infection from an affected village. Of the 199 families and 1001 individuals in the village, 159 (80%) and 513 (51%) were affected, respectively, comprising 237 (46%) males with peak incidence at 40–50 years. The acute illness caused polyarthritis in 233 (46%), and of them 230 (98%) progressed to chronic arthritic disability (CAD). Of the CAD patients, 102 (44%) had recovered in 141 days (range 30–210 days) from the disability state whilst 128 (56%) had persisting disability which lasted 12, 24, and 36 months in 41 (17.8%), 22 (9.5%), and 14 (6.1%) individuals, respectively. Carpal tunnel syndrome (CTS) manifested in 110 (21%). Females showed preponderance for complications over males: acute arthritis 147 versus 86, P = 0.001; CAD 136 versus 84, P = 0.029; CTS 88 versus 22, P = 0.001; relapses 105 versus 68, P = 0.001. Chikungunya was highly communicable and caused lasting crippling complications

Star formation in low-redshift cluster dwarf galaxies

Evolution of galaxies in dense environments can be affected by close encounters with neighbouring galaxies and interactions with the intracluster medium. Dwarf galaxies (dGs) are important as their low mass makes them more susceptible to these effects than giant systems. Combined luminosity functions (LFs) in the r and u band of 15 galaxy clusters were constructed using archival data from the Canada–France–Hawaii Telescope. LFs were measured as a function of clustercentric radius from stacked cluster data. Marginal evidence was found for an increase in the faint-end slope of the u-band LF relative to the r-band with increasing clustercentric radius. The dwarf-to-giant ratio (DGR) was found to increase toward the cluster outskirts, with the u-band DGR increasing faster with clustercentric radius compared to the r-band. The dG blue fraction was found to be ∼2 times larger than the giant galaxy blue fraction over all clustercentric distance (∼5σ level). The central concentration (C) was used as a proxy to distinguish nucleated versus non-nucleated dGs. The ratio of high-C to low-C dGs was found to be ∼2 times greater in the inner cluster region compared to the outskirts (2.8σ level). The faint-end slope of the r-band LF for the cluster outskirts (0.6 ≤ r/r200 \u3c 1.0) is steeper than the Sloan Digital Sky Survey field LF, while the u-band LF is marginally steeper at the 2.5σ level. Decrease in the faint-end slope of the r- and u-band cluster LFs towards the cluster centre is consistent with quenching of star formation via ram pressure stripping and galaxy–galaxy interactions