Neutrino neutral reaction on 4He, effects of final state interaction and realistic NN force

The inelastic neutral reaction of neutrino on 4He is calculated microscopically, including full final state interaction among the four nucleons. The calculation is performed using the Lorentz integral transform (LIT) method and the hyperspherical-harmonic effective interaction approach (EIHH), with a realistic nucleon-nucleon interaction. A detailed energy dependent calculation is given in the impulse approximation. With respect to previous calculations, this work predicts an increased reaction cross-section by 10%-30% for neutrino temperature up to 15 MeV.Comment: 4 pages, 2 fig

Automated detection of missteps during community ambulation in patients with Parkinson’s disease: a new approach for quantifying fall risk in the community setting

Background: Falls are a leading cause of morbidity and mortality among older adults and patients with neurological disease like Parkinson’s disease (PD). Self-report of missteps, also referred to as near falls, has been related to fall risk in patients with PD. We developed an objective tool for detecting missteps under real-world, daily life conditions to enhance the evaluation of fall risk and applied this new method to 3 day continuous recordings. Methods: 40 patients with PD (mean age ± SD: 62.2 ± 10.0 yrs, disease duration: 5.3 ± 3.5 yrs) wore a small device that contained accelerometers and gyroscopes on the lower back while participating in a protocol designed to provoke missteps in the laboratory. Afterwards, the subjects wore the sensor for 3 days as they carried out their routine activities of daily living. An algorithm designed to automatically identify missteps was developed based on the laboratory data and was validated on the 3 days recordings. Results: In the laboratory, we recorded 29 missteps and more than 60 hours of data. When applied to this dataset, the algorithm achieved a 93.1% hit ratio and 98.6% specificity. When we applied this algorithm to the 3 days recordings, patients who reported two falls or more in the 6 months prior to the study (i.e., fallers) were significantly more likely to have a detected misstep during the 3 day recordings (p = 0.010) compared to the non-fallers. Conclusions: These findings suggest that this novel approach can be applied to detect missteps during daily life among patients with PD and will likely help in the longitudinal assessment of disease progression and fall risk

alpha-particle photoabsorption with a realistic nuclear force

The 4He total photoabsorption cross section is calculated with the realistic nucleon-nucleon potential Argonne V18 and the three-nucleon force (3NF) Urbana IX. Final state interaction is included rigorously via the Lorentz Integral Transform method. A rather pronounced giant resonance with peak cross sections of 3 (3.2) mb is obtained with (without) 3NF. Above 50 MeV strong 3NF effects, up to 35%, are present. Good agreement with experiment is found close to threshold. A comparison in the giant resonance region is inconclusive, since present data do not show a unique picture.Comment: 13 pages, 4 figures; corrected experimental data in Fig.4b and slightly modified discussion of Fig.4

Compressive Fluorescence Microscopy for Biological and Hyperspectral Imaging

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware implementations of CS-based acquisition devices---especially in optics---have only started being addressed. This paper presents an implementation of compressive sensing in fluorescence microscopy and its applications to biomedical imaging. Our CS microscope combines a dynamic structured wide-field illumination and a fast and sensitive single-point fluorescence detection to enable reconstructions of images of fluorescent beads, cells and tissues with undersampling ratios (between the number of pixels and number of measurements) up to 32. We further demonstrate a hyperspectral mode and record images with 128 spectral channels and undersampling ratios up to 64, illustrating the potential benefits of CS acquisition for higher dimensional signals which typically exhibits extreme redundancy. Altogether, our results emphasize the interest of CS schemes for acquisition at a significantly reduced rate and point out to some remaining challenges for CS fluorescence microscopy.Comment: Submitted to Proceedings of the National Academy of Sciences of the United States of Americ