Carbon burning in intermediate mass primordial stars

The evolution of a zero metallicity 9 M_s star is computed, analyzed and compared with that of a solar metallicity star of identical ZAMS mass. Our computations range from the main sequence until the formation of a massive oxygen-neon white dwarf. Special attention has been payed to carbon burning in conditions of partial degeneracy as well as to the subsequent thermally pulsing Super-AGB phase. The latter develops in a fashion very similar to that of a solar metallicity 9 M_s star, as a consequence of the significant enrichment in metals of the stellar envelope that ensues due to the so-called third dredge-up episode. The abundances in mass of the main isotopes in the final ONe core resulting from the evolution are X(^{16}O) approx 0.59, X(^{20}Ne) approx 0.28 and X(^{24}Mg) approx 0.05. This core is surrounded by a 0.05 M_s buffer mainly composed of carbon and oxygen, and on top of it a He envelope of mass 10^{-4} M_sComment: 11 pages, 11 figures, accepted for publication in A&

SARS-CoV-2 infection: A role for S1P/S1P receptor signaling in the nervous system?

The recent coronavirus disease (COVID-19) is still spreading worldwide. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus responsible for COVID-19, binds to its receptor angiotensin-converting enzyme 2 (ACE2), and replicates within the cells of the nasal cavity, then spreads along the airway tracts, causing mild clinical manifestations, and, in a majority of patients, a persisting loss of smell. In some individuals, SARS-CoV-2 reaches and infects several organs, including the lung, leading to severe pulmonary disease. SARS-CoV-2 induces neurological symptoms, likely contributing to morbidity and mortality through unknown mechanisms. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with pleiotropic properties and functions in many tissues, including the nervous system. S1P regulates neurogenesis and inflammation and it is implicated in multiple sclerosis (MS). Notably, Fingolimod (FTY720), a modulator of S1P receptors, has been approved for the treatment of MS and is being tested for COVID-19. Here, we discuss the putative role of S1P on viral infection and in the modulation of inflammation and survival in the stem cell niche of the olfactory epithelium. This could help to design therapeutic strategies based on S1P-mediated signaling to limit or overcome the host–virus interaction, virus propagation and the pathogenesis and complications involving the nervous system