Stochastic resonance with different periodic forces in overdamped two coupled anharmonic oscillators

We study the stochastic resonance phenomenon in the overdamped two coupled anharmonic oscillators with Gaussian noise and driven by different external periodic forces. We consider (i) sine, (ii) square, (iii) symmetric saw-tooth, (iv) asymmetric saw-tooth, (v) modulus of sine and (vi) rectified sinusoidal forces. The external periodic forces and Gaussian noise term are added to one of the two state variables of the system. The effect of each force is studied separately. In the absence of noise term, when the amplitude $f$ of the applied periodic force is varied cross-well motion is realized above a critical value ($f_{\mathrm{c}}$) of $f$. This is found for all the forces except the modulus of sine and rectified sinusoidal forces.Stochastic resonance is observed in the presence of noise and periodic forces. The effect of different forces is compared. The logarithmic plot of mean residence time $\tau_{\mathrm{MR}}$ against $1/(D - D_{\mathrm{c}})$ where $D$ is the intensity of the noise and $D_{\mathrm{c}}$ is the value of $D$ at which cross-well motion is initiated shows a sharp knee-like structure for all the forces. Signal-to-noise ratio is found to be maximum at the noise intensity $D=D_{\mathrm{max}}$ at which mean residence time is half of the period of the driving force for the forces such as sine, square, symmetric saw-tooth and asymmetric saw-tooth waves. With modulus of sine wave and rectified sine wave, the $SNR$ peaks at a value of $D$ for which sum of $\tau_{MR}$ in two wells of the potential of the system is half of the period of the driving force. For the chosen values of $f$ and $\omega$, signal-to-noise ratio is found to be maximum for square wave while it is minimum for modulus of sine and rectified sinusoidal waves.Comment: 13 figures,27 page

Influence of Cu concentration on the structural, morphological, optical and catalytic properties of TiO2 thin films

Pristine titanium oxide (TiO2) and Cu doped TiO2 thin films of ~2.0 µm thicknesses have been deposited on glass substrates by sol-gel dip coating technique. The deposited films are even and more adherent to the substrate. The consequences of incorporation of Cu ions of different concentration in TiO2 lattice towards the structural, morphological and optical characteristics of prepared thin films have been investigated. Cu doping alters crystallite size and morphology of doped TiO2 films marginally. Gradual increase in concentration of Cu atoms into TiO2 matrix expands the absorption window of prepared films to visible region. The decrease in excitonic energy upon Cu doping promotes the charge separation in TiO2 semiconductor. Depending upon Cu concentration, exciton life time is extended fairly which leads to improved electron-hole separation and enhanced oxidation-reduction reactions at the surface of TiO2 semiconductors. The advantage of thin film catalyst over the other catalyst structures has been exhibited by the reusability nature of Cu-TiO2 films. This study reveals that an ideal amount of Cu doping can increase the photocatalytic performance of TiO2 thin films efficiently

Simultano UV-spektrofotometrijsko određivanje ramiprila, acetilsalicilne kiseline i atorvastatin kalcija u kapsulama primjenom kemometrijskih metoda

In the present work, three different spectrophotometric methods for simultaneous estimation of ramipril, aspirin and atorvastatin calcium in raw materials and in formulations are described. Overlapped data was quantitatively resolved by using chemometric methods, viz. inverse least squares (ILS), principal component regression (PCR) and partial least squares (PLS). Calibrations were constructed using the absorption data matrix corresponding to the concentration data matrix. The linearity range was found to be 1-5, 10-50 and 2-10 µg mL–1 for ramipril, aspirin and atorvastatin calcium, respectively. The absorbance matrix was obtained by measuring the zero-order absorbance in the wavelength range between 210 and 320 nm. A training set design of the concentration data corresponding to the ramipril, aspirin and atorvastatin calcium mixtures was organized statistically to maximize the information content from the spectra and to minimize the error of multivariate calibrations. By applying the respective algorithms for PLS 1, PCR and ILS to the measured spectra of the calibration set, a suitable model was obtained. This model was selected on the basis of RMSECV and RMSEP values. The same was applied to the prediction set and capsule formulation. Mean recoveries of the commercial formulation set together with other figures of merit (calibration sensitivity, selectivity, limit of detection, limit of quantification and analytical sensitivity) were estimated. Validity of the proposed approaches was successfully assessed for analyses of drugs in the various prepared physical mixtures and formulations.U radu su opisane tri različite spektrofotometrijske metode za određivanje ramiprila, acetilsalicilne kiseline i atorvastatin kalcija u sirovinama i formulacijama. Preklapanje podataka kvantitativno je riješeno pomoću kemometrijskih metoda, tj. metodama inverznih najmanjih kvadrata (ILS), regresije glavnog sastojka (PCR) i djelomičnih najmanjih kvadrata (PLS). Kalibracije su postavljene pomoću matrice podataka za apsorpciju koja odgovara matrici pripadajućih koncentracija. Područje linearnosti za ramipril iznosilo je 1–5, za acetilsalicilnu kiselinu 10–50, a za atorvastatin kalcij 2–10 µg mL–1. Matrica s apsorbancijama dobivena je mjerenjem apsorbancije nultog reda na valnim duljinama između 210 i 320 nm. Set podataka za koncentracije ramiprila, acetilsalicilne kiseline i atorvastatin kalcija u smjesi statistički je tako organiziran da osigura maksimalnu količinu informacije u spektrima i minimalizira grešku multivarijantnih kalibracija. Primjenom odgovarajućih algoritama za PLS, PCR i ILS na snimljene spektre kalibracijskog seta dobiven je dobar model, koji je odabran na temelju RMSECV i RMSEP vrijednosti. Isti model je primijenjen i na set s predviđenim vrijednostima i na kapsule sa smjesom ove tri ljekovite tvari. Određena je srednja vrijednost povrata za komercijalnu formulaciju te ostale analitičke izvedbene značajke (kalibracijska osjetljivost, selektivnost, granica dokazivanja, granica određivanja i analitička osjetljivost). Potvrđena je primjenjljivost predloženih metoda u analizama lijekova u fizičkim smjesama i u gotovim ljekovitim oblicima

Spectrophotometric determination of tizanidine and orphenadrine via ion pair complex formation using eosin Y

A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method is based on the formation of a binary complex between the studied drugs and eosin Y in aqueous buffered medium (pH 3.5). Under the optimum conditions, the binary complex showed absorption maxima at 545 nm for tizanidine and 542 nm for orphenadrine. The calibration plots were rectilinear over concentration range of 0.5-8 μg/mL and 1-12 μg/mL with limits of detection of 0.1 μg/mL and 0.3 μg/mL for tizanidine and orphenadrine respectively. The different experimental parameters affecting the development and stability of the complex were studied and optimized. The method was successfully applied for determination of the studied drugs in their dosage forms; and to the content uniformity test of tizanidine in tablets

Ion pair-HPLC method for the simultaneous estimation of quinapril and hydrochlorothiazide in tablets

A simple, precise and rapid HPLC method has been developed and validated for the estimation of quinapril and hydrochlorothiazide simultaneously in combined dosage form. The mobile phase used was a mixture of 0.1% v/v triethylamine (pH 3.5), containing 1 mM of hexane sulphonic acid: acetonitrile (30:70% v/v). The detection of quinapril and hydrochlorothiazide was carried out on photo diode array detector at 220 nm. Results of the analysis were validated statistically and by recovery studies. The proposed method can be successfully used to determine the drug contents of marketed formulation

Influence of Cu concentration on the structural, morphological, optical and catalytic properties of TiO₂ thin films

475-482Pristine titanium oxide (TiO2) and Cu doped TiO2 thin films of ~2.0 µm thicknesses have been deposited on glass substrates by sol-gel dip coating technique. The deposited films are even and more adherent to the substrate. The consequences of incorporation of Cu ions of different concentration in TiO2 lattice towards the structural, morphological and optical characteristics of prepared thin films have been investigated. Cu doping alters crystallite size and morphology of doped TiO2 films marginally. Gradual increase in concentration of Cu atoms into TiO2 matrix expands the absorption window of prepared films to visible region. The decrease in excitonic energy upon Cu doping promotes the charge separation in TiO2 semiconductor. Depending upon Cu concentration, exciton life time is extended fairly which leads to improved electron-hole separation and enhanced oxidation-reduction reactions at the surface of TiO2 semiconductors. The advantage of thin film catalyst over the other catalyst structures has been exhibited by the reusability nature of Cu-TiO2 films. This study reveals that an ideal amount of Cu doping can increase the photocatalytic performance of TiO2 thin films efficiently

Application of electrospun natural biopolymer nanofibers

10.2174/1573413711309040002Current Nanoscience94423-43