A semi-Lagrangian scheme for the game pp-Laplacian via pp-averaging

We present and analyze an approximation scheme for the two-dimensional game $p$-Laplacian in the framework of viscosity solutions. The approximation is based on a semi-Lagrangian scheme which exploits the idea of $p$-averages. We study the properties of the scheme and prove that it converges, in particular cases, to the viscosity solution of the game $p$-Laplacian. We also present a numerical implementation of the scheme for different values of $p$; the numerical tests show that the scheme is accurate.Comment: 34 pages, 3 figures. To appear on Applied Numerical Mathematic

The proton structure function F2 in the resonance region

Unique measurement of the proton structure function F2 in a wide two-dimensional region of x and Q**2 has been reported. The accessible kinematics covers entire resonance region up to W=2.5 GeV in the Q**2 interval from 0.1 to 4.5 GeV**2. Obtained data allowed for the first time an evaluation of moments of the structure function F2 directly from experimental data as well as an intensive study of the Bloom-Gilman duality phenomenon.Comment: 6 pages, 4 figures, Proceedings of GDH2002 Conference, 3-6 July 2002, Genova, Italy, to be published in World Scientifi

SCINTILLA A European project for the development of scintillation detectors and new technologies for nuclear security

Europe monitors transits using radiation detectors to prevent illicit trafficking of nuclear materials. The SCINTILLA project aims to develop a toolbox of innovative technologies designed to address different usage cases. This article will review the scope, approach, results of the first benchmark campaign and future plans of the SCINTILLA project.Comment: To appear on the Proceedings of the 13th ICATPP Conference on Astroparticle, Particle, Space Physics and Detectors for Physics Applications, Villa Olmo (Como, Italy), 23--27 October, 2013, to be published by World Scientific (Singapore

Variety seeking behavior in the wine domain: A consumers segmentation using big data

This study investigates variety seeking behavior in the wine domain. Since variety seeking depends on brand strategies and consumers’ preferences for different types of vines and denominations, a bi-dimensional perspective is adopted. Two new variety seeking measures are defined, namely the Wine Index of Diversity and Brand Index of Diversity. A finite mixture regression model is implemented to identify and characterize groups of households sharing similar variety seeking behavior in a statistically representative sample of 8,313 Italian households. Four groups are identified based on consumer characteristics and their purchasing behavior. The largest group is “switchers,” which includes consumers showing a relatively higher wine diversity than brand diversity. Estimates reveal the “habitual” group, that lives in the southern Italy and consumes wine less frequently than all other groups. The “loyal” group includes the youngest consumers with an above average income, who reside in the northern regions. Finally, the “variety seekers” are older, have the highest incomes, and live in the central regions. This grouping provides insights into the effects of brand and wine typology on consumers’ choices

Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer. Efficacy in combination with hormonal therapy

Background: Data on efficacy of bevacizumab (B) beyond first-line taxane -including regimen (BT) as first-line treatment are lacking. Although preclinical results that anti-angiogenic agents combined with hormonal therapy (HT) could be active, no clinical data exist about combination of maintenance Bevacizumab (mBev) with HT.Methods: Thirty-five patients who experienced a response after first-line BT, were given mBev at the dose of 15 mg/kg every 3 weeks. Among 30 pts with hormonal receptor-positive metastatic breast cancer (MBC), 20 (66.6%) received HT with mBev (mHTBev). Objective of the study was the outcome and safety of mBev and in two groups of patients receiving HT or not.Results: Complete response and partial response was achieved/maintained in 4 (11.4%) and 13 (37.1%) patients, respectively (overall response rate: 48.5%). Clinical benefit was obtained on 23 patients (65.7%). Median of mBev PFS and clinical benefit were 6.8 months (95% CI: 0.8-12.7) and 17.1 months (95% CI :12.2-21.9), respectively. Median PFS of patients who received mHTBev was longer than mBev without HT (13 months and 4.1 months, respectively, p = 0.05). The most common severe toxicities were proteinuria (11.4%) and hypertension (8.5%). No additional toxicity was observed with HTBev.Conclusion: Maintenance bevacizumab with or without anti-hormonal therapy in patients with hormone receptor positive breast cancer is tolerable and associated with long-term clinical outcome; these results encourage the strategy of prolonging bevacizumab until progression in combination with anti-hormonal agents

Health-related quality of life and functional changes in DMD:A 12-month longitudinal cohort study

Family caregivers of people with amyotrophic lateral sclerosis (ALS) live stressful lives in which they spend most of their time caring for their loved ones and managing difficult situations, thereby reducing the time spent in taking care of themselves. This situation may last several years. Previous literature has widely highlighted that this situation reduces caregivers' quality of life and increases their psychological distress and risk of health problems, but there is a lack of studies that focus on psychological interventions for these situations. This qualitative study examined a pilot experience of two mutual support groups for family caregivers of people with ALS. The aim was to identify caregivers' needs, the prominent aspects of their experience, and to understand whether and how this intervention strategy might help them. Six partners (four men and two women) and six adult children (five women and one man) participated in the groups, which were conducted in northern Italy. After the support groups finished, participants underwent semi-structured interviews. The authors conducted a content analysis of the transcripts of the interviews and the 20 group sessions. The thematic areas identified were "caregiving," "being the son/daughter of a person with ALS," "being the partner of a person with ALS," "group experience" and "group evaluation." The caregiving experience was profoundly different depending on whether the caregiver was a son/daughter or a partner of a patient with ALS. Moreover, comparison with peers and mutual support helped participants to better cope with ALS and its consequences, to improve their care for their relatives and to overcome typical caregiver isolation. These results suggest the usefulness of involving communities in caregiver support in order to create new networks and activate personal and social resources for well-being