Schwarzschild Black Hole in Noncommutative Spaces

We study the effects of noncommutative spaces on the horizon, the area spectrum and Hawking temperature of a Schwarzschild black hole. The results show deviations from the usual horizon, area spectrum and the Hawking temperature. The deviations depend on the parameter of space-space noncommutativity.Comment: 4 pages, accepted for publication in Gen.Rel.Gra

Are you going to the party: depends, who else is coming? [Learning hidden group dynamics via conditional latent tree models]

Scalable probabilistic modeling and prediction in high dimensional multivariate time-series is a challenging problem, particularly for systems with hidden sources of dependence and/or homogeneity. Examples of such problems include dynamic social networks with co-evolving nodes and edges and dynamic student learning in online courses. Here, we address these problems through the discovery of hierarchical latent groups. We introduce a family of Conditional Latent Tree Models (CLTM), in which tree-structured latent variables incorporate the unknown groups. The latent tree itself is conditioned on observed covariates such as seasonality, historical activity, and node attributes. We propose a statistically efficient framework for learning both the hierarchical tree structure and the parameters of the CLTM. We demonstrate competitive performance in multiple real world datasets from different domains. These include a dataset on students' attempts at answering questions in a psychology MOOC, Twitter users participating in an emergency management discussion and interacting with one another, and windsurfers interacting on a beach in Southern California. In addition, our modeling framework provides valuable and interpretable information about the hidden group structures and their effect on the evolution of the time series

Dynamics of inflationary cosmology in TVSD model

Within the framework of a model Universe with time variable space dimensions (TVSD), known as decrumpling or TVSD model, we study TVSD chaotic inflation and obtain dynamics of the inflaton, scale factor and spatial dimension. We also study the quantum fluctuations of the inflaton field and obtain the spectral index and its running in this model. Two classes of examples have been studied and comparisons made with the standard slow-roll formulae. We compare our results with the recent Wilkinson Microwave Anisotropy Probe (WMAP) data.Comment: 18 pages, 3 figures, accepted in Mod. Phys. Lett.

Chaotic Inflation with Time-Variable Space Dimensions

Assuming the space dimension is not constant but decreases during the expansion of the Universe, we study chaotic inflation with the potential $m^2\phi^2/2$. Our investigations are based on a model Universe with variable space dimensions. We write down field equations in the slow-roll approximation, and define slow-roll parameters by assuming the number of space dimensions decreases continuously as the Universe expands. The dynamical character of the space dimension shifts the initial and final value of the inflaton field to larger values. We obtain an upper limit for the space dimension at the Planck length. This result is in agreement with previous works for the effective time variation of the Newtonian gravitational constant in a model Universe with variable space dimensions.Comment: 19 pages, To be published in Int.J.Mod.Phys.D. Minor changes to match accepted versio

Limits on the Time Evolution of Space Dimensions from Newton's Constant

Limits are imposed upon the possible rate of change of extra spatial dimensions in a decrumpling model Universe with time variable spatial dimensions (TVSD) by considering the time variation of (1+3)-dimensional Newton's constant. Previous studies on the time variation of (1+3)-dimensional Newton's constant in TVSD theory had not been included the effects of the volume of the extra dimensions and the effects of the surface area of the unit sphere in D-space dimensions. Our main result is that the absolute value of the present rate of change of spatial dimensions to be less than about 10^{-14}yr^{-1}. Our results would appear to provide a prima facie case for ruling the TVSD model out. We show that based on observational bounds on the present-day variation of Newton's constant, one would have to conclude that the spatial dimension of the Universe when the Universe was at the Planck scale to be less than or equal to 3.09. If the dimension of space when the Universe was at the Planck scale is constrained to be fractional and very close to 3, then the whole edifice of TVSD model loses credibility.Comment: 22 pages, accepted for publication in Int.J.Mod.Phys.

Exogenously added GPI-anchored tissue inhibitor of matrix metal loproteinase-1 (TIMP-1) displays enhanced and novel biological activities

The family of tissue inhibitors of metalloproteinases (TIMPs) exhibits diverse physiological/biological functions including the inhibition of active matrix metalloproteinases, regulation of proMMP activation, cell growth, and the modulation of angiogenesis. TIMP-1 is a secreted protein that can be detected on the cell surface through its interaction with surface proteins. The diverse biological functions of TIMP-1 are thought to lie, in part, in the kinetics of TIMP-1/MMP/surface protein interactions. Proteins anchored by glycoinositol phospholipids (GPIs), when purified and added to cells in vitro, are incorporated into their surface membranes. A GPI anchor was fused to TIMP-1 to generate a reagent that could be added directly to cell membranes and thus focus defined concentrations of TIMP-1 protein on any cell surface independent of protein-protein interaction. Unlike native TIMP-1, exogenously added GPI-anchored TIMP-1 protein effectively blocked release of MMP-2 and MMP-9 from osteosarcoma cells. TIMP-1-GP1 was a more effective modulator of migration and proliferation than TIMP-1. While control hTIMP-1 protein did not significantly affect migration of primary microvascular endothelial cells at the concentrations tested, the GPI-anchored TIMP-1 protein showed a pronounced suppression of endothelial cell migration in response to bFGF. In addition, TIMP-1-GPI was more effective at inducing microvascular endothelial proliferation. In contrast, fibroblast proliferation was suppressed by the agent. Reagents based on this method should assist in the dissection of the protease cascades and activities involved in TIMP biology. Membrane-fixed TIMP-1 may represent a more effective version of the protein for use in therapeutic expression

Evaluation of immunostimulatory effects of a commercial herbal extract on avian influenza subtype H9N2 and Newcastle disease vaccination in chickens

Contrary to several vaccination programs to protect against bird flu and Newcastle disease (ND), these diseases remain a significant threat to the poultry industry. Improving the immune responses is important for many reasons such as vaccine failure, immunosuppressive diseases, and antibiotics misuse. Nowadays, research on materials likely to have immune-enhancing effects is increasing. Factors, substances, or compounds that can regulate different functions of the immune system can be used to enhance specific and even nonspecific responses to vaccines. The ability of herbal extracts to improve the immune system supports their use as immune stimulants. The present study aimed to examine the effects of barley malt extract in drinking water on humoral immunity of broiler chickens against ND and Avian Influenza (AI) disease subtype H9N2 vaccines. A total of 225 one-day-old broiler chicks (Ross strain) were divided into 5 groups of 3 subgroups and each subgroup had 15 chicks. Group A, B, and C chickens received 0.2%, 0.3%, and 0.5% of malt extract respectively in drinking water. Group D chickens did not get malt extract. Group E chickens did not receive malt extract and Newcastle and AI vaccines as the control group. All groups except group E were vaccinated with live Newcastle vaccine (B1 strain) intraocularly and AI-ND subtype H9N2 killed vaccine subcutaneously on the 7th day. Antibody titer against NDs and AI vaccines was considered by the Hemagglutination Inhibition test (HI test).  Malt extract at 0.5% concentration, at all periods after vaccination, enhanced the systemic antibody response to ND vaccine in broiler chickens, but this extract had no significant effect on antibody response against the AI vaccine.Conclusion:  Inoculation of ND vaccines with barley malt extract as an immune-boosting agent induces extensive immune responses involved in HI-NDV Ab titers

Dissolved air flotation and centrifugation as methods for oil recovery from ruptured microalgal cells

Solvent-free microalgal lipid recovery is highly desirable for safer, more sustainable and more economical microalgal oil production. Dispersed air flotation and centrifugation were evaluated for the ability to separate oil and debris from a slurry mixture of osmotically fractured Chaetoceros muelleri cells with and without utilizing collectors. Microalgal oil partially phase-separated as a top layer and partially formed an oil-in-water emulsion. Although collectors, such as sodium dodecyl sulphate enhanced selective flotation, by just adjusting the pH and cell concentration of the mixture, up to 78% of the lipids were recovered in the froth. Using centrifugation of fractured microalgal slurry resulted in removal of 60% cell debris and up to 68.5% of microalgal oil was present in the supernatant. Both methods, centrifugation and flotation provided options for separation of microalgal oil from C. muelleri slurry with similar fatty acid recoveries of 57% and 60%, respectively