11 research outputs found
Lipoprotein lipase responds similarly to tinzaparin as to conventional heparin during hemodialysis
Glucocorticoid-induced osteoporosis in the lumbar spine, forearm and mandible of nephrotic patients: A double-blind study on the high-dose, long-term effects of prednisone versus deflazacort
Correlations between calcineurin phosphatase inhibition and cyclosporine metabolites concentrations in kidney transplant recipients: implications for immunoassays
Glucocorticoid-induced osteoporosis in the lumbar spine, forearm and mandible of nephrotic patients: A double-blind study on the high-dose, long-term effect of Prednisone versus Deflazacort
Differential regulation of adrenal corticosteroids after restriction-induced drinking in rats
Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study.
BACKGROUND
Intravenous pulse methylprednisolone (MP) is commonly included in the management of severe ANCA associated vasculitis (AAV) despite limited evidence of benefit. We aimed to evaluate outcomes in patients who had, or had not received MP, along with standard therapy for remission induction in severe AAV.
METHODS
We retrospectively studied 114 consecutive patients from five centres in Europe and the United States with a new diagnosis of severe AAV (creatinine > 500 μmol/L or dialysis dependency) and that received standard therapy (plasma exchange, cyclophosphamide and high-dose oral corticosteroids) for remission induction with or without pulse MP between 2000 and 2013. We evaluated survival, renal recovery, relapses, and adverse events over the first 12 months.
RESULTS
Fifty-two patients received pulse MP in addition to standard therapy compared to 62 patients that did not. There was no difference in survival, renal recovery or relapses. Treatment with MP associated with higher risk of infection during the first 3 months (hazard ratio (HR) 2.7, 95%CI [1.4-5.3], p = 0.004) and higher incidence of diabetes (HR 6.33 [1.94-20.63], p = 0.002), after adjustment for confounding factors.
CONCLUSIONS
The results of this study suggest that addition of pulse intravenous MP to standard therapy for remission induction in severe AAV may not confer clinical benefit and may be associated with more episodes of infection and higher incidence of diabetes