110 research outputs found
Identifying challenges towards practical quantum advantage through resource estimation: the measurement roadblock in the variational quantum eigensolver
Recent advances in Noisy Intermediate-Scale Quantum (NISQ) devices have
brought much attention to the potential of the Variational Quantum Eigensolver
(VQE) and related techniques to provide practical quantum advantage in
computational chemistry. However, it is not yet clear whether such algorithms,
even in the absence of device error, could achieve quantum advantage for
systems of practical interest and how large such an advantage might be. To
address these questions, we have performed an exhaustive set of benchmarks to
estimate number of qubits and number of measurements required to compute the
combustion energies of small organic molecules to within chemical accuracy
using VQE as well as state-of-the-art classical algorithms. We consider several
key modifications to VQE, including the use of Frozen Natural Orbitals, various
Hamiltonian decomposition techniques, and the application of fermionic marginal
constraints. Our results indicate that although Frozen Natural Orbitals and
low-rank factorizations of the Hamiltonian significantly reduce the qubit and
measurement requirements, these techniques are not sufficient to achieve
practical quantum computational advantage in the calculation of organic
molecule combustion energies. This suggests that new approaches to estimation
leveraging quantum coherence, such as Bayesian amplitude estimation
[arxiv:2006.09350, arxiv:2006.09349], may be required in order to achieve
practical quantum advantage with near-term devices. Our work also highlights
the crucial role that resource and performance assessments of quantum
algorithms play in identifying quantum advantage and guiding quantum algorithm
design.Comment: 27 pages, 18 figure
Genome-wide diversity and global migration patterns in dromedaries follow ancient caravan routes
Dromedaries have been essential for the prosperity of civilizations in arid environments and the dispersal of humans, goods and cultures along ancient, cross-continental trading routes. With increasing desertification their importance as livestock species is rising rapidly, but little is known about their genome-wide diversity and demographic history. As previous studies using few nuclear markers found weak phylogeographic structure, here we detected fine-scale population differentiation in dromedaries across Asia and Africa by adopting a genome-wide approach. Global patterns of effective migration rates revealed pathways of dispersal after domestication, following historic caravan routes like the Silk and Incense Roads. Our results show that a Pleistocene bottleneck and Medieval expansions during the rise of the Ottoman empire have shaped genome-wide diversity in modern dromedaries. By understanding subtle population structure we recognize the value of small, locally adapted populations and appeal for securing genomic diversity for a sustainable utilization of this key desert species
Phosphate feeding to permit growth while maintaining secondary product synthesis
Maintaining high metabolic activities for extended periods by feeding small amounts of the growth limiting nutrient was examined for the production of cycloheximide by Streptomyces griseus . Batch studies indicated that increased initial phosphate levels led to increased cell concentrations, stimulated glucose utilization, and over a limited range (<0.6 g/l KH 2 PO 4 ) did not adversely affect cycloheximide production rates. Semi-continuous phosphate feeding was observed to permit limited cell growth, and to enhance metabolic activities (i. e. glucose utilization). The effect of semi-continuous phosphate feeding on antibiotic production depended on the feed rate, with high feed rates suppressing production.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46756/1/253_2004_Article_BF00451634.pd
Action of dimeric hybrids of native and selectively alkylated ribonuclease A on double-stranded ribonucleic acid
The genus Lipara Meigen (Diptera, Chloropidae), systematics, morphology, behaviour, and ecology
Volume: 117Start Page: 1End Page: 2
Incorporation and Phosphorylation of 5-Azacytidine by Normal and T4-Phage-Infected Cells of E. coli
Acid deoxyribonuclease. IX. 5'-Hydroxy-terminal and penultimate nucleotides of oligonucleotides obtained from calf thymus deoxyribonucleic acid
Differential Incorportion of 5-Azapyrimidines into the RNA of Phage f2 and of Bacterial Host
- …