Is Campylobacter fetus subspecies venerealis infection a cause of reproductive failure in dairy cows in Iran?

Summary Bovine genital campylobacteriosis is one of the most economically important diseases of dairy cattle resulting in lowered fertility, embryo mortality and abortion, repeated returns to service, reduced pregnancy rates and extended calving intervals. While the occurrence of repeat breeding syndrome and abortions are reported from many Iranian dairy cattle farms, little information is available regarding the presence of bovine genital campylobacteriosis in Iran. The present report describes detection of Campylobacter fetus subsp. venerealis infection in two out of eight repeat breeder Holstein Friesian cows (Bos Taurus) using a PCR method in a herd with a history of subfertility in Mashhad, in the northeast of Iran

TP87 153. Implantación de dos sistemas de oxigenador de membrana extracorpórea a un paciente en dos ingresos: Uno como recuperación, otro como puente a otra asistencia

IntroducciónLos programas de asistencias mecánicas de corta duración se empiezan a desarrollar en nuestro país. Uno de los más utilizados es el oxigenador de membrana extracor-pórea (ECMO), cuya mayor indicación en nuestro entorno es como puente al trasplante. Presentamos un caso en el que se coloca como recuperación, y tras 3 meses otra nueva como puente a otra asistencia.Material y métodosPaciente de 61 años que ingresa por trombosis de stent en descendente anterior (DA), presentando shock cardiogénico refractario a fármacos y balón de contrapulsación. Dada la situación se coloca ECMO venoarterial que se retira a las 72h por mejoría, dándose de alta el paciente a los 19 días.Tres meses después el paciente ingresa con bajo gasto y edema de pulmón, implantándose un ECMO venoarterial en el box de intensivos como puente a asistencia univentricular Levitronix, que se coloca 10h después en quirófano. Se reinterviene dos veces por taponamiento y se extuba a los 7 días, momento en que se incluye en alarma 0. Tras 27 días con Levitronix izquierda, la paciente sufre un ictus y retiramos de lista, falleciendo la paciente.ResultadosLos dos ECMO cumplieron su objetivo: uno de recuperación y el otro de puente a la asistencia.ConclusionesComo describimos en este caso, el ECMO es muy útil y fácil de implantar en pacientes con el objetivo de la recuperación o como puente al trasplante. Las asistencias no están exentas de complicaciones

Self-interrupted synthesis of sterically hindered aliphatic polyamide dendrimers

Hydrolytically and enzymatically stable nanoscale synthetic constructs, with well-defined structures that exhibit antimicrobial activity, offer exciting possibilities for diverse applications in the emerging field of nanomedicine. Herein, we demonstrate that it is the core conformation, rather than periodicity, that ultimately controls the synthesis of sterically hindered aliphatic polyamide dendrimers. The latter self-interrupt at a predictable low generation number due to backfolding of their peripheral groups, which in turn leads to well-defined nanoarchitectures

Is Campylobacter fetus subspecies venerealis infection a cause of reproductive failure in dairy cows in Iran?

Summary Bovine genital campylobacteriosis is one of the most economically important diseases of dairy cattle resulting in lowered fertility, embryo mortality and abortion, repeated returns to service, reduced pregnancy rates and extended calving intervals. While the occurrence of repeat breeding syndrome and abortions are reported from many Iranian dairy cattle farms, little information is available regarding the presence of bovine genital campylobacteriosis in Iran. The present report describes detection of Campylobacter fetus subsp. venerealis infection in two out of eight repeat breeder Holstein Friesian cows (Bos Taurus) using a PCR method in a herd with a history of subfertility in Mashhad, in the northeast of Iran

Asymmetric fluorination reactions promoted by chiral hydrogen bonding‐based organocatalysts

Fluorinated compounds can exhibit interesting biological properties. The importance of these species has made that the chemistry of fluorine has experienced a great development. On this review, the recent advances on asymmetric fluorination reactions promoted by chiral hydrogen bonding‐based organocatalysts are discussed. Hence, examples using phosphoric acid, carboxylic acid, (thio)urea and squaramide derivatives are illustrated. The growth of this field is amazing. We have only considered pivotal works in which direct fluorination takes place using a fluorinating agent, leaving aside the reactions where a fluorine atom is incorporated from the beginning as part of other reactants. Herein, the scarce existing examples on this field of research have been compiled.The authors thank Ministerio de Economía, Industria y Competitividad (MINECO‐FEDER CTQ2016‐75816‐C2‐1‐P, CTQ2017‐88091‐P and PID2019‐104379RB‐C21) and Gobierno de Aragón‐Fondo Social Europeo (Research Group E07_20R) for financial support of our research.Peer reviewe

Self-interrupted synthesis of sterically hindered aliphatic polyamide dendrimers

2,2-Bis(azidomethyl)propionic acid was prepared in four steps and 85% yield from the commercially available 2,2-bis(hydroxymethyl) propionic acid and used as the starting building block for the divergent, convergent, and double-stage convergent-divergent iterative methods for the synthesis of dendrimers and dendrons containing ethylenediamine (EDA), piperazine (PPZ), and methyl 2,2- bis(aminomethyl)propionate (COOMe) cores. These cores have the same multiplicity but different conformations. A diversity of synthetic methods were used for the synthesis of dendrimers and dendrons. Regardless of the method used, a self-interruption of the synthesis was observed at generation 4 for the dendrimer with an EDA core and at generation 5 for the one with a PPZ core, whereas for the COOMe core, self-interruption was observed at generation 6 dendron, which is equivalent to generation 5 dendrimer. Molecular modeling and molecular-dynamics simulations demonstrated that the observed self-interruption is determined by the backfolding of the azide groups at the periphery of the dendrimer. The latter conformation inhibits completely the heterogeneous hydrogenation of the azide groups catalyzed by 10% Pd/carbon as well as homogeneous hydrogenation by the Staudinger method. These self-terminated polyamide dendrimers are enzymatically and hydrolytically stable and also exhibit antimicrobial activity. Thus, these nanoscale constructs open avenues for biomedical applications

Self-interrupted synthesis of sterically hindered aliphatic polyamide dendrimers

2,2-Bis(azidomethyl)propionic acid was prepared in four steps and 85% yield from the commercially available 2,2-bis(hydroxymethyl)propionic acid and used as the starting building block for the divergent, convergent, and double-stage convergent–divergent iterative methods for the synthesis of dendrimers and dendrons containing ethylenediamine (EDA), piperazine (PPZ), and methyl 2,2-bis(aminomethyl)propionate (COOMe) cores. These cores have the same multiplicity but different conformations. A diversity of synthetic methods were used for the synthesis of dendrimers and dendrons. Regardless of the method used, a self-interruption of the synthesis was observed at generation 4 for the dendrimer with an EDA core and at generation 5 for the one with a PPZ core, whereas for the COOMe core, self-interruption was observed at generation 6 dendron, which is equivalent to generation 5 dendrimer. Molecular modeling and molecular-dynamics simulations demonstrated that the observed self-interruption is determined by the backfolding of the azide groups at the periphery of the dendrimer. The latter conformation inhibits completely the heterogeneous hydrogenation of the azide groups catalyzed by 10% Pd/carbon as well as homogeneous hydrogenation by the Staudinger method. These self-terminated polyamide dendrimers are enzymatically and hydrolytically stable and also exhibit antimicrobial activity. Thus, these nanoscale constructs open avenues for biomedical applications