A phenomenological exploration of experience of Syrian dentists with online Course “Traumatic dental injuries”

BackgroundSeveral learning modalities have been implemented to improve learning about Traumatic Dental Injuries (TDIs) worldwide. Free online courses about TDIs might be an effective and convenient approach for equipping Syrian dentists with essential competencies during the Syrian crisis. Therefore, this qualitative study with a descriptive phenomenological method was undertaken to explore the lived experience of Syrian dentists enrolled in an online course about TDIs and investigate areas requiring improvement.MethodsEthical approval was obtained from the Faculty of Dentistry, Damascus University, and the University of Dundee. Educational contents of the TDI course were developed. About 10 dentists who completed the TDI course, were interviewed. The interviews were recorded, transcribed, and analyzed to identify emerging themes. Inductive thematic analysis was performed to extract all data.ResultsAbout 10 clustered categories were first developed and this has led to the emergence of 3 themes that represent the lived experience including usefulness, challenges, and recommendations. Participants were so motivated and keen to take advantage of the course despite the personal, technical problems, and crisis-related challenges. TDIs course was effective for general and specialists despite the challenges they experienced. Factors that lead to effective TDIs courses as reported by participants were flexibility in time and location, interactivity with colleagues, other commitments, quantity and quality of content, easiness, and variety of virtual environment tools. Conversely, negative attitudes were linked to factors like lack of interest, unfamiliarity with the learning environment and tools, late participation, lack of confidence, anxiety about independent learning and insufficient interactivity and engagement tools.ConclusionSyrian dentists can benefit from online courses if constraints and various learning needs are addressed during the design and delivery of online courses. Future work is still required to identify other effective instructional modalities that equip Syrian dentists to overcome challenges and enhance their learning

Mutations in C4orf26, Encoding a Peptide with In Vitro Hydroxyapatite Crystal Nucleation and Growth Activity, Cause Amelogenesis Imperfecta

Autozygosity mapping and clonal sequencing of an Omani family identified mutations in the uncharacterized gene, C4orf26, as a cause of recessive hypomineralized amelogenesis imperfecta (AI), a disease in which the formation of tooth enamel fails. Screening of a panel of 57 autosomal-recessive AI-affected families identified eight further families with loss-of-function mutations in C4orf26. C4orf26 encodes a putative extracellular matrix acidic phosphoprotein expressed in the enamel organ. A mineral nucleation assay showed that the protein’s phosphorylated C terminus has the capacity to promote nucleation of hydroxyapatite, suggesting a possible function in enamel mineralization during amelogenesis

Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study

BACKGROUND: A genetic predisposition to Preterm Labor (PTL) and Preterm Premature Rupture of Membranes (PPROM) has been suggested; however the relevance of polymorphisms and ancestry to susceptibility to PTL and PPROM in different populations remains unclear. The aim of this study was to evaluate the contribution of maternal and fetal SNPs in the IL1B, IL6, IL6R, TNFA, TNFR, IL10, TLR2, TLR4, MMP9, TIMP1 and TIMP2 genes and the influence of ancestry background in the susceptibility to PTL or PPROM in Brazilian women. METHODS: Case–control study conducted at a tertiary hospital in São Paulo State, Brazil. We included women with PTL or PPROM and their babies (PTL: 136 women and 88 babies; PPROM: 65 women and 44 babies). Control group included 402 mother-babies pairs of term deliveries. Oral swabs were collected for identification of AIMs by fragment analysis and SNPs by Taqman® SNP Genotyping Assays and PCR. Linkage Disequilibrium and Hardy-Weinberg proportions were evaluated using Genepop 3.4. Haplotypes were inferred using the PHASE algorithm. Allele, genotype and haplotype frequencies were compared by Fisher’s exact test or χ(2) and Odds Ratio. Logistic regression was performed. Clinical and sociodemographic data were analyzed by Fisher’s exact test and Mann–Whitney. RESULTS: PTL was associated with European ancestry and smoking while African ancestry was protective. The fetal alleles IL10-592C (rs800872) and IL10-819C (rs1800871) were also associated with PTL and the maternal haplotype TNFA-308G-238A was protective. Maternal presence of IL10-1082G (rs1800896) and TLR2A (rs4696480) alleles increased the risk for PPROM while TNFA-238A (rs361525) was protective. Family history of PTL/PPROM was higher in cases, and time to delivery was influenced by IL1B-31T (rs1143627) and TLR4-299G (rs4986790). CONCLUSION: There is an association between European ancestry and smoking and PTL in our Brazilian population sample. The presence of maternal or fetal alleles that modify the inflammatory response increase the susceptibility to PTL and PPROM. The family history of PTL/PPROM reinforces a role for genetic polymorphisms in susceptibility to these outcomes

The relation between protein energy malnutrition and gingival status in children

Thepurpose of this study was to investigate the relation between protein-energy malnutrition and gingivitis in children in Damascus and its suburbs. For this purpose we used a random sample of 840 male and female children aged 6-t2 years. Their gums were examined. The bleedins indexes were recorded for both primaw and permanent teeth. Anthropometric measures were taken: Weight for age. Height for age and Weight for Height. We found that gingivitis increased among low weight children [44%]compared to normal children [31%]. It was more severe in low-height children in comparison to others. These findings necessitate the promotion of preventive care in order to insure gingival hygiene, particularly by following a balanced diet</jats:p

Native Arabic Language Use Acceptability and Adequacy in Health Professional Instruction: Students and Faculty’s Perspectives

Purpose: This study had three main purposes which were (a) to assess the adequacy and desirability of Arabic in health professional instruction by investigating students and teachers’ perspectives and attitudes, (b) to explore aspects of Arabic medical translations which are not meeting expectations, and lastly, (c) to examine whether the level of education is a predictor of attitude. Method: A questionnaire survey of medical and dental students at the undergraduate and postgraduate levels was carried out in 2019 at major universities in Damascus. Faculty members were also invited to participate. 346 respondents in total completed the questionnaires. Data were processed and analysed quantitatively and qualitatively. Attitude theory and Health belief model were employed to analyse and interpret the study findings. Results: Overall attitudes toward Arabic as a language of instruction were relatively negative. Students consistently exhibited a preference for English as the language of instruction. The one-way Welch’s ANOVA test found a significant difference among the main subgroups (undergraduates, postgraduates, faculty). Findings also showed that students and teachers suffer from the inadequacy of Arabic medical translations in quality and quantity. Respondents were generally dissatisfied with the proficiency of medical translators, and the majority agreed that there is a shortage of up-to-date Arabic study materials. Discussion: Students’ implicitly considered Arabic as a threat to their career advancement. Inadequacy of teaching in Arabic was more evident among postgraduates. Syrian students’ desire to join the international medical community was one of the data implications. This study shed new light on the anomalous Syrian educational system as it provided a theortical framework which could further understanding of the interaction between different concepts that affect attitudes towards the language of instruction. In terms of directions for future research, qualitative field research is recommended to give an idiographic account of students and teachers’ subjective perception of the career threats posed by using Arabic as the medium of instruction in medical education

Dietary patterns and oral health in schoolchildren from Damascus, Syrian Arab Republic ‫السورية‬ ‫العربية‬ ‫اجلمهورية‬ ‫دمشق،‬ ‫يف‬ ‫املدارس‬ ‫أطفال‬ ‫لدى‬ ‫الفم‬ ‫وصحة‬ ‫الغذائية‬ ‫األنامط‬

ABSTRACT This study investigated the association between dietary patterns and oral health in primary-school children from Damascus. A total of 504 children aged 6-12 years were enrolled and food frequency questionnaires were distributed to their guardians to evaluate food consumption. Dental health was evaluated by gingival index and presence of untreated dental caries. Consumption of food groups was lower than recommended frequencies, whereas consumption of sugars was high. High sugar consumption (OR 5.26), low consumption of dairy products (OR 2.45) and poor oral hygiene (OR 2.98) remained risk factors for dental caries in multiple regression analysis. Poor oral hygiene (OR 18.5), high consumption of sugars (OR 1.82) and low frequency of tooth brushing (OR 1.98) also remained as risk factors for gingivitis regardless of all confounders included in the analysis. Comprehensive educational programmes about dietary patterns and their relation to oral health should be provided for children and their guardians. Habitudes alimentaires et santé bucco-dentaire chez des écoliers à Damas (République arabe syrienne) RÉSUMÉ La présente étude a examiné l&apos;association entre les habitudes alimentaires et la santé bucco-dentaire chez des écoliers du primaire à Damas. Au total, 504 enfants âgés de 6 à 12 ans ont été recrutés et des questionnaires de fréquence alimentaire ont été distribués aux personnes qui avaient la charge des enfants pour évaluer leur consommation d&apos;aliments. La santé dentaire a été évaluée par rapport à un indice gingival et la présence de caries dentaires non soignées. La consommation des aliments des différents groupes était inférieure aux recommandations, alors que la consommation de sucre était supérieure