Beyond the virtual intracranial stenting challenge 2007: non-Newtonian and flow pulsatility effects

The attached article is a post print version of the final published version which may be accessed at the link below. Crown Copyright (c) 2010 Published by Elsevier Ltd. All rights reserved.The Virtual Intracranial Stenting Challenge 2007 (VISC’07) is becoming a standard test case in computational minimally invasive cerebrovascular intervention. Following views expressed in the literature and consistent with the recommendations of a report, the effects of non-Newtonian viscosity and pulsatile flow are reported. Three models of stented cerebral aneurysms, originating from VISC’07 are meshed and the flow characteristics simulated using commercial computational fluid dynamics (CFD) software. We conclude that non-Newtonian and pulsatile effects are important to include in order to discriminate more effectively between stent designs

Vascular device interaction with the endothelium

Copyright @ 2008 Elsevier. This is the post-print version of the article.Cerebral stents and Intra Aortic Balloon Pumps (IABP) are examples of mechanical devices that are inserted into arteries to restore flows to clinically healthy states. The stent and the IABP ‘correct’ the arterial flow by static dilation and by cyclical occlusion respectively. As this presentation shows, these functions are effectively modelled by current engineering practice. As interventions however, by their very nature they involve physical contact between a non-biological structure and the sensitive endothelial surface. The possible damage to the endothelium is not currently well addressed and we also consider this issue. Cerebral stents generally have two primary clinical objectives: to mechanically dilate a stenosed artery and to have minimal detrimental impact upon local blood flow characteristics. These objectives are well served at the arterial scale as these devices are evidently effective in opening up diseased arteries and restoring vital flows. However, at the near-wall micro-scale the picture is less satisfactory, as thin stent wires apply stresses to the endothelium and glycocalyx and the local flow is disturbed rather than being ideally streamlined. This causes further interaction with this endothelium topography. Wall Shear Stress (WSS) is the measure commonly used to indicate the interaction between fluid and wall but it is a broad brush approach that loses fidelity close to the wall. We will present simulation results of blood flow through a stented cerebral saccular aneurysm under these limitations of WSS. The Intra Aortic Balloon Pump (IABP) is a widely used temporary cardiac assist device. The balloon is usually inserted from the iliac artery, advanced in the aorta until it reaches the desired position; with its base just above the renal bifurcation and the tip approximately 10cm away from the aortic valve. The balloon is inflated and deflated every- (1:1), every other- (1:2) or every second (1:3) cardiac cycle. Balloon inflation, which takes place during early diastole, causes an increase in the pressure of the aortic root which leads to an increase in coronary flow. Balloon deflation which takes place during late diastole achieves one of the main IABP therapeutic effects by reducing left ventricular afterload. Unavoidably, the balloon contacts the inner wall of the aorta with every inflation/deflation cycle. This repeated event and possible contact with atherosclerotic plaque have been reported to be responsible for balloon rupture. However, there has not been a methodical study to investigate the mechanical effects of balloon-wall interaction. For example, during inflation the balloon approaches the endothelium as it displaces a volume of blood proximally and distally. This squeezing process generates shear stresses, which hasn't yet been quantified. Similarly, when the balloon moves away from the endothelium during deflation, it generates micro pressure differences that may impose stretching (pulling) stresses on the endothelium cells. Both of the above cases indicate that a very high spatial resolution is required in order to fully understand the process of interaction between device and endothelium, and to interpret the effects at the cellular level

A Management Strategy for Multi-Source Heat Pump Systems

The recent H2020 IDEAS project is oriented to the study of multi-source heat pump systems by investigating their behavior through dynamic simulations and on-field experiments in real small and large-scale prototypes respectively. One of the main aims of the project is the exploitation of available free energy sources, solar, air and ground using the heat pump technology. The key point in the investigated multi-source heat pump system is the optimal management of the renewable sources and the keeping of the ground storage available also in case of undersize of it and in case of buildings with unbalanced thermal load profile. In the last year of the project the algorithm for the control of sources and devices in the IDEAS system has been developed to maximize the use of renewable energies and at the same time to minimize the consumption of auxiliary energy. The present paper shows the details of this part of the project highlighting limits, potential and properties of the management system with a discussion of the results obtained from the on-field experiments. In the last part of the project, the implementation of weather forecast and artificial intelligence in the algorithm is planned

Non-Newtonian and flow pulsatility effects in simulation models of a stented intracranial aneurysm

Permission to redistribute provided by publishers.Three models of different stent designs implanted in a cerebral aneurysm, originating from the Virtual Intracranial Stenting Challenge'07, are meshed and the flow characteristics simulated using commercial computational fluid dynamics (CFD) software in order to investigate the effects of non-Newtonian viscosity and pulsatile flow. Conventional mass inflow and wall shear stress (WSS) output are used as a means of comparing the cfd simulations. In addition, a WSS distribution is presented, which clearly discriminates in favour of the stent design identified by other groups. It is concluded that non-Newtonian and pulsatile effects are important to include in order to avoid underestimating wss, to understand dynamic flow effects, and to discriminate more effectively between stent designs. © Authors 2011

Blazar surveys with WMAP and Swift

We present the preliminary results from two new surveys of blazars that have direct implications on the GLAST detection of extragalactic sources from two different perspectives: microwave selection and a combined deep X-ray/radio selection. The first one is a 41 GHz flux-limited sample extracted from the WMAP 3-yr catalog of microwave point sources. This is a statistically well defined sample of about 200 blazars and radio galaxies, most of which are expected to be detected by GLAST. The second one is a new deep survey of Blazars selected among the radio sources that are spatially coincident with serendipitous sources detected in deep X-ray images (0.3-10 keV) centered on the Gamma Ray Bursts (GRB) discovered by the Swift satellite. This sample is particularly interesting from a statistical viewpoint since a) it is unbiased as GRBs explode at random positions in the sky, b) it is very deep in the X-ray band (\fx \simgt $10^{-15}$ \ergs) with a position accuracy of a few arc-seconds, c) it will cover a fairly large (20-30 square deg.) area of sky, d) it includes all blazars with radio flux (1.4 GHz) larger than 10 mJy, making it approximately two orders of magnitude deeper than the WMAP sample and about one order of magnitude deeper than the deepest existing complete samples of radio selected blazars, and e) it can be used to estimate the amount of unresolved GLAST high latitude gamma-ray background and its anisotropy spectrum.Comment: 3 pages, 3 figures, to appear in Proc. of the 1st GLAST Symposium, Feb 5-8, 2007, Stanford, AIP, Eds. S. Ritz, P. F. Michelson, and C. Meega

Development and calibration of a 1D thermo-fluid dynamic model of ventilation in tunnels

In complex, large civil infrastructures where ventilation has a crucial role for the safety of users in both normal operation and hazardous scenarios, the correct prediction of flow and heat transfer parameters is of fundamental importance. While full 3D simulation is applicable only to a limited extent, and the resort to 1D modeling is a common practice in both design and evaluation phases, the limitation of such models lies in the choice of transfer parameters, such as friction loss coefficients and heat transfer coefficients. In this work, an original approach based on the Finite Volume integration of the 1D flow and energy equations is presented. Such equations are to be solved on a network of ducts, representing the ventilation system in the 11.6 km long Mont Blanc Tunnel with a spatial resolution of 10 m. A preliminary calibration of a set of friction loss coefficients against a rich experimental dataset collected throughout a dedicated set of in situ tests is of particular concern here, as it is carried out by means of genetic optimization algorithms. Predictions of the flow field are in remarkable agreement with the experimental data, with an overall RMS error of - 0.42 m/s. Further refinements and possible parameter choices are also discussed

An integrated approach for the analysis and modeling of road tunnel ventilation. Part II: Numerical model and its calibration

The present work represents the second and final part of a twofold study aiming at the definition and validation of an integrated methodology for the analysis and modeling of road tunnel ventilation systems. A numerical approach is presented, based on the Finite Volume integration of the 1D mechanical and thermal energy conservation equations on a network of ducts, representing the ventilation system of the 11.6 km long Mont Blanc Tunnel. The set of distributed and concentrated loss coefficients, representing dissipation of mechanical energy by friction in each part of the ventilation system, is calibrated against a rich experimental dataset, collected throughout a dedicated set of in situ tests and presented in the first part of the work. The calibration of the model is carried out by means of genetic optimization algorithms. Predictions of the flow field using the calibrated parameters are in remarkable agreement with the experimental data, with an overall RMS error of \ub1 0.27 m/s, i.e. of the same order of the accuracy of the measurement probes. Further validation against a selection of field data recorded by the tunnel monitoring and control system is brought forward, highlighting the robustness and potential general applicability of the proposed approach

Systematic search for gamma-ray periodicity in active galactic nuclei detected by the Fermi Large Area Telescope

We use nine years of gamma-ray data provided by the Fermi Large Area Telescope (LAT) to systematically study the light curves of more than two thousand active galactic nuclei (AGN) included in recent Fermi-LAT catalogs. Ten different techniques are used, which are organized in an automatic periodicity-search pipeline, in order to search for evidence of periodic emission in gamma rays. Understanding the processes behind this puzzling phenomenon will provide a better view about the astrophysical nature of these extragalactic sources. However, the observation of temporal patterns in gamma-ray light curves of AGN is still challenging. Despite the fact that there have been efforts on characterizing the temporal emission of some individual sources, a systematic search for periodicities by means of a full likelihood analysis applied to large samples of sources was missing. Our analysis finds 11 AGN, of which 9 are identified for the first time, showing periodicity at more than 4sigma in at least four algorithms. These findings will help in solving questions related to the astrophysical origin of this periodic behavior.Comment: 16 pages, 5 figures, 4 tables. Accepted by Ap