Long term Arecibo monitoring of the water megamaser in MG J0414+0534

We monitored the 22 GHz maser line in the lensed quasar MG J0414+0534 at z=2.64 with the 300-m Arecibo telescope for almost two years to detect possible additional maser components and to measure a potential velocity drift of the lines. The main maser line profile is complex and can be resolved into a number of broad features with line widths of 30-160 km/s. A new maser component was tentatively detected in October 2008 at a velocity of +470 km/s. After correcting for the estimated lens magnification, we find that the H2O isotropic luminosity of the maser in MG J0414+0534 is about 26,000 solar luminosities, making this source the most luminous ever discovered. Both the main line peak and continuum flux densities are surprisingly stable throughout the period of the observations. An upper limit on the velocity drift of the main peak of the line has been estimated from our observations and is of the order of 2 km/s per year. We discuss the results of the monitoring in terms of the possible nature of the maser emission, associated with an accretion disk or a radio jet. This is the first time that such a study is performed in a water maser source at high redshift, potentially allowing us to study the parsec-scale environment around a powerful radio source at cosmological distances.Comment: 5 pages, 2 figures, to appear in the Proceedings of the IAU Symposium 287, 2012, "Cosmic masers: from OH to H0

Evaluation of the composition and antimicrobial activities of essential oils from four species of Lamiaceae Martinov native to Iran

In this study the essential oils obtained from four different plant species belonging to the Lamiaceae family were extracted by means of hydrodistillation and their composition and antimicrobial activity were evaluated. About 66 components were identified by using gas chromatography-mass spectrometry (GC-MS), and among all, thymol (67.7%), oleic acid (0.5-62.1%), (-)-caryophyllene oxide (0.4-24.8%), α-pinene (1.1-19.4%), 1,8-cineole (0.2-15.4%), palmitic acid (0.32-13.28%), ( +)spathulenol (11.16%), and germacrene D (0.3-10.3%) were the most abundant in all the species tested (i.e. Thymus daenensis, Nepeta sessilifolia, Hymenocrater incanus, and Stachys inflata). In particular, only the composition of essential oils from H. incanus was completely detected (99.13%), while that of the others was only partially detected. Oxygenated monoterpenes (75.57%) were the main compounds of essential oil from T. daenensis; sesquiterpenes hydrocarbons (26.88%) were the most abundant in S. inflata; oxygenated sesquiterpenes (41.22%) were mainly detected in H. incanus essential oil, while the essential oil from N. sessilifolia was mainly composed of non-terpene and fatty acids (77.18%). Due to their slightly different composition, also the antibacterial activity was affected by the essential oil tested. Indeed, the highest antibacterial and antifungal activities were obtained with the essential oil from T. daenensis by means of the inhibition halo (39 ± 1 and 25 ± 0 mm) against Gram-positive strains such as Staphylococcus aureus and Aspergillus brasiliensis. The minimal inhibitory concentration (MIC) and minimal bactericidal/fungicidal concentration (MBC/MFC) of the essential oils obtained from the four species varied from 16 to 2000 μg/mL and were strictly affected by the type of microorganism tested. As an example, the essential oils from H. incanus and S. inflata were the most effective against the Gram-negative bacterium Pseudomonas aeruginosa (MIC 16 and 63 μg/ml, respectively), which is considered one of the most resistant bacterial strain. Therefore, the essential oils obtained from the four species contained a suitable phytocomplexes with potential applications in different commercial area such as agriculture, food, pharmaceutical and cosmetic industries. Moreover, these essential oils can be considered a valuable natural alternative to some synthetic antibiotics, thanks to their ability to control the growth of different bacteria and fungi

Jabuticaba (Myrciaria jaboticaba) peel as a sustainable source of anthocyanins and ellagitannins delivered by phospholipid vesicles for alleviating oxidative stress in human keratinocytes

The Brazilian berry scientifically known as jabuticaba is a fruit covered by a dark purple peel that is still rich in bioactives, especially polyphenols. Considering that, this work was aimed at obtaining an extract from the peel of jabuticaba fruits, identifying its main components, loading it in phospholipid vesicles specifically tailored for skin delivery and evaluating their biological efficacy. The extract was obtained by pressurized hot water extraction (PHWE), which is considered an easy and low dissipative method, and it was rich in polyphenolic compounds, especially flavonoids (ortho-diphenols and condensed tannins), anthocyanins (cyanidin 3-O-glucoside and delphinidin 3-O-glucoside) and gallic acid, which were responsible for the high antioxidant activity detected using different colorimetric methods (DPPH, FRAP, CUPRAC and metal chelation). To improve the stability and extract effectiveness, it was incorporated into ultradeformable phospholipid vesicles (transfersomes) that were modified by adding two different polymers (hydroxyethyl cellulose and sodium hyaluronate), thus obtaining HEcellulose-transfersomes and hyaluronan-transfersomes. Transfersomes without polymers were the smallest, as the addition of the polymer led to the formation of larger vesicles that were more stable in storage. The incorporation of the extract in the vesicles promoted their beneficial activities as they were capable, to a greater extent than the solution used as reference, of counteracting the toxic effect of hydrogen peroxide and even of speeding up the healing of a wound performed in a cell monolayer, especially when vesicles were enriched with polymers. Given that, polymer enriched vesicles may represent a good strategy to produce cosmetical and cosmeceutical products with beneficial properties for skin

An outlook on modern and sustainable approaches to the management of grape pomace by integrating green processes, biotechnologies and advanced biomedical approaches

Grape pomace is the main solid residue of wine industry, mainly composed of seeds, skins and stalks, all containing high amounts of valuable phytochemicals. Considering its high potential, in this review, an outlook on different resources and products, which can be obtained by the recovery of grape pomace is provided. Special attention has been devoted to the analysis of chemical, physical and biotechnological processes to be applied and also to the high value compounds and products, such as supplements, nutraceuticals and cosmeceuticals, that can be manufactured. In particular, in the first part of the review, an update on the composition of grape pomace has been provided along with the analysis of its traditional fate. In the second part, the more modern and green approaches tested to the sustainable management of grape pomace are reported and discussed

Stability and Antioxidant Activity of Hydro-Glyceric Extracts Obtained from Different Grape Seed Varieties Incorporated in Cosmetic Creams

Grape seeds are agro-industrial by-products, which if improperly managed, may be responsible for socioeconomic and environmental problems. Nevertheless, it is possible to effectively valorize them by means of extraction of the bioactive compounds, especially the antioxidant phenolic molecules, using a safe, green, and environmentally-friendly extractive medium (i.e., hydro-glyceric solution). In the present study, the extraction was performed using seeds from two Lebanese varieties, Obeidi and Asswad Karech, and three international varieties, Marselan, Syrah, and Cabernet Franc. The type and amount of phenolic compounds were identified by High-Performance Liquid Chromatography (HPLC). Marselan was the extract richer in catechins (132.99 +/- 9.81 mu g/g of dried matter), and it also contained a higher amount of phenolic compounds (49.08 +/- 0.03 mg of gallic acid equivalent/g of dry matter and 10.02 +/- 0.24 mg of proanthocyanidin content/g of dry matter). The antioxidant capacity of the extracts was assessed using three different colorimetric assays including 2,2-DiPhenyl-1-PicrylHydrazyl (DPPH), CUPRIC ion Reducing Antioxidant Capacity (CUPRAC), and Ferric Reducing Antioxidant Power (FRAP). As expected, Marselan exhibited the highest antioxidant activity; as well, the total phenolic and proanthocyanidin content were the highest. The stability of the Marselan extract incorporated into a commercial cream, was performed at three different temperatures (4, 25, and 50 degrees C), and four different concentrations (5, 4, 3, 2%), over a period of 4 months, using different methods such as centrifugation, Heat-Shock Cycles, pH, and viscosity. All Marselan hydro-glyceric extract formulations were proven to be stable over the entire 4 months, where the highest stability was achieved at 4 degrees C and the least at 50 degrees C. This study supports the suitability of the incorporation of phenolic extracts into commercial creams to enrich the cosmetic industry with effective, natural, and safe skincare products