Origin of the high energy neutrino flux at IceCube

We discuss the spectrum of the different components in the astrophysical neutrino flux reaching the Earth and the possible contribution of each component to the high-energy IceCube data. We show that the diffuse flux from cosmic ray interactions with gas in our galaxy implies just 2 events among the 54 event sample. We argue that the neutrino flux from cosmic ray interactions in the intergalactic (intracluster) space depends critically on the transport parameter $\delta$ describing the energy dependence in the diffusion coefficient of galactic cosmic rays. Our analysis motivates a E^{-2.1} neutrino spectrum with a drop at PeV energies that fits well the data, including the non-observation of the Glashow resonance at 6.3 PeV. We also show that a cosmic ray flux described by an unbroken power law may produce a neutrino flux with interesting spectral features (bumps and breaks) related to changes in the cosmic ray composition.Comment: 19 pages, new section about changes in CR composition, version to appear in Ap

El Chorizo japonés : semanario inocente: Año I Número 2 - 17 marzo 1915

Recurso electrónico. València : BVNP, 2015Recurso electrónico. Año 1: chorizada n. 2 (17 marzo 1915). Valencia : BVNP, 2015. Archivo Rafael Solaz Albert

El Chorizo japonés : semanario inocente: Año I Número 6 - 14 abril 1915

Recurso electrónico. València : BVNP, 2015Recurso electrónico. Año 1: chorizada n. 6 (14 abril 1915). Valencia : BVNP, 2017. Archivo Rafael Solaz Albert

Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses

10 páginas, 6 figuras. Contiene material suplementarioGlucocorticoids (GCs) regulate skin homeostasis and combat cutaneous inflammatory diseases; however, adverse effects of chronic GC treatments limit their therapeutic use. GCs bind and activate the GC receptor and the mineralocorticoid receptor (MR), transcription factors that recognize identical hormone responsive elements. Whether epidermal MR mediates beneficial or deleterious GC effects is of great interest for improving GC-based skin therapies. MR epidermal knockout mice exhibited increased keratinocyte proliferation and differentiation and showed resistance to GC-induced epidermal thinning. However, crucially, loss of epidermal MR rendered mice more sensitive to inflammatory stimuli and skin damage. MR epidermal knockout mice showed increased susceptibility to phorbol 12-myristate 13-acetate-induced inflammation with higher cytokine induction. Likewise, cultured MR epidermal knockout keratinocytes had increased phorbol 12-myristate 13-acetate-induced NF-κB activation, highlighting an anti-inflammatory function for MR. GC-induced transcription was reduced in MR epidermal knockout keratinocytes, at least partially due to decreased recruitment of GC receptor to hormone responsive element-containing sequences. Our results support a role for epidermal MR in adult skin homeostasis and demonstrate nonredundant roles for MR and GC receptor in mediating GC actions.This work was supported by grant SAF2011-28115 and SAF2014-59474-R (MINECO, Spanish Government). JB and EC are recipients of FPI (BES-2012-0578) and FPU (AP201-06094) fellowships of MINECO, respectively. We thank COST ADMIRE BM- 1301 and NURCAMEIN (SAF2015-71878-REDT) for support for dissemination.Peer reviewe

The mineralocorticoid receptor plays a transient role in mouse skin development

3 páginas, 2 figuras. Contiene material suplemenarioGlucocorticoid (GC) hormones can bind two structurally and functionally related steroid receptors: the GC Receptor (GR or Nr3c1) and the mineralocorticoid receptor (MR or Nr3c2), which recognize the same DNA response elements and act as ligand-dependent transcription factors. While the crucial role of GR for skin homeostasis has been widely characterized, the exact role of MR in this tissue deserves further study. We assessed NR3C2 expression in developing and adult WT mouse skin and found a transient peak at embryonic day (E)16.5, which along with low levels of HSD11B2, the enzyme inactivating GCs, supports a role for GC-MR complexes in epidermal maturation. Consistent with this observation, MR-/- embryonic skin showed alterations in early epidermal differentiation that resolved postnatally. The lack of a more severe skin phenotype of MR-/- mice suggests functional compensation by GR in this tissue in the perinatal period.This work was supported by JSPS KAKENHI grant numbers 25870545 and 15K09772. Spanish Ministerio de Ciencia e Innovación. Grant Numbers: SAF2011-28115, SAF2014-59474-RPeer Reviewe

El Fallero : periòdic festero, buñolero y sandunquero: Año 1926 Número 6

Recurso electrónico. Valencia : BVN

El Fallero : periòdic festero, buñolero y sandunquero: Año 1936 Número 16

Recurso electrónico. Valencia : BVN

El Fallero : periòdic festero, buñolero y sandunquero: Año 1928 Número 8

Recurso electrónico. Valencia : BVN

El Fallero : periòdic festero, buñolero y sandunquero: Año 1924 Número 4

Recurso electrónico. Valencia : BVN

El Fallero : periòdic festero, buñolero y sandunquero: Año 1932 Número 12

Recurso electrónico. Valencia : BVN