Incompressible fluid inside an astrophysical black hole?

It is argued that under natural hypothesis the Fermions inside a black hole formed after the collapse of a neutron star could form a non compressible fluid (well before reaching the Planck scale) leading to some features of integer Quantum Hall Effect. The relations with black hole entropy are analyzed. Insights coming from Quantum Hall Effect are used to analyze the coupling with Einstein equations. Connections with some cosmological scenarios and with higher dimensional Quantum Hall Effect are shortly pointed out.Comment: 30 pages, 2 figures. Accepted for publication on Physical Review D: references added, typos corrected, test polishe

The UV behavior of Gravity at Large N

A first step in the analysis of the renormalizability of gravity at Large N is carried on. Suitable resummations of planar diagrams give rise to a theory in which there is only a finite number of primitive superficially divergent Feynman diagrams. The mechanism is similar to the the one which makes renormalizable the 3D Gross-Neveu model at large N. Some potential problems in fulfilling the Slavnov-Taylor and the Zinn-Justin equations are also pointed out.Comment: 17 pages, 9 figures. To appear on Phys. Rev. D. Two more references, further technical details and the discussion of the KLT relations at large N have been include

Vacuum static compactified wormholes in eight-dimensional Lovelock theory

In this paper new exact solutions in eight dimensional Lovelock theory will be presented. These solutions are vacuum static wormhole, black hole and generalized Bertotti-Robinson space-times with nontrivial torsion. All the solutions have a cross product structure of the type $M_{5}\times \Sigma_{3}$ where $M_{5}$ is a five dimensional manifold and $\Sigma_{3}$ a compact constant curvature manifold. The wormhole is the first example of a smooth vacuum static Lovelock wormhole which is neither Chern-Simons nor Born-Infeld. It will be also discussed how the presence of torsion affects the "navigableness" of the wormhole for scalar and spinning particles. It will be shown that the wormhole with torsion may act as "geometrical filter": a very large torsion may "increase the traversability" for scalars while acting as a "polarizator" on spinning particles. This may have interesting phenomenological consequences.Comment: LaTeX, 27 pages, no figures, some comments added. Version accepted for publication in Physical Review

On the computational complexity of dynamic slicing problems for program schemas

This is the preprint version of the Article - Copyright @ 2011 Cambridge University PressGiven a program, a quotient can be obtained from it by deleting zero or more statements. The field of program slicing is concerned with computing a quotient of a program that preserves part of the behaviour of the original program. All program slicing algorithms take account of the structural properties of a program, such as control dependence and data dependence, rather than the semantics of its functions and predicates, and thus work, in effect, with program schemas. The dynamic slicing criterion of Korel and Laski requires only that program behaviour is preserved in cases where the original program follows a particular path, and that the slice/quotient follows this path. In this paper we formalise Korel and Laski's definition of a dynamic slice as applied to linear schemas, and also formulate a less restrictive definition in which the path through the original program need not be preserved by the slice. The less restrictive definition has the benefit of leading to smaller slices. For both definitions, we compute complexity bounds for the problems of establishing whether a given slice of a linear schema is a dynamic slice and whether a linear schema has a non-trivial dynamic slice, and prove that the latter problem is NP-hard in both cases. We also give an example to prove that minimal dynamic slices (whether or not they preserve the original path) need not be unique.This work was partly supported by the Engineering and Physical Sciences Research Council, UK, under grant EP/E002919/1

Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle

Amyotrophic Lateral Sclerosis is a neurodegenerative disease caused by progressive loss of motor neurons, which severely compromises skeletal muscle function. Evidence shows that muscle may act as a molecular powerhouse, whose final signals generate in patients a progressive loss of voluntary muscle function and weakness leading to paralysis. This pathology is the result of a complex cascade of events that involves a crosstalk among motor neurons, glia, and muscles, and evolves through the action of converging toxic mechanisms. In fact, mitochondrial dysfunction, which leads to oxidative stress, is one of the mechanisms causing cell death. It is a common denominator for the two existing forms of the disease: sporadic and familial. Other factors include excitotoxicity, inflammation, and protein aggregation. Currently, there are limited cures. The only approved drug for therapy is riluzole, that modestly prolongs survival, with edaravone now waiting for new clinical trial aimed to clarify its efficacy. Thus, there is a need of effective treatments to reverse the damage in this devastating pathology. Many drugs have been already tested in clinical trials and are currently under investigation. This review summarizes the already tested drugs aimed at restoring muscle-nerve cross-talk and on new treatment options targeting this tissue

Machine-Readable Privacy Certificates for Services

Privacy-aware processing of personal data on the web of services requires managing a number of issues arising both from the technical and the legal domain. Several approaches have been proposed to matching privacy requirements (on the clients side) and privacy guarantees (on the service provider side). Still, the assurance of effective data protection (when possible) relies on substantial human effort and exposes organizations to significant (non-)compliance risks. In this paper we put forward the idea that a privacy certification scheme producing and managing machine-readable artifacts in the form of privacy certificates can play an important role towards the solution of this problem. Digital privacy certificates represent the reasons why a privacy property holds for a service and describe the privacy measures supporting it. Also, privacy certificates can be used to automatically select services whose certificates match the client policies (privacy requirements). Our proposal relies on an evolution of the conceptual model developed in the Assert4Soa project and on a certificate format specifically tailored to represent privacy properties. To validate our approach, we present a worked-out instance showing how privacy property Retention-based unlinkability can be certified for a banking financial service.Comment: 20 pages, 6 figure

Cooking pasta with Lie groups

We extend the (gauged) Skyrme model to the case in which the global isospin group (which usually is taken to be SU(N)) is a generic compact connected Lie group G. We analyze the corresponding field equations in (3+1) dimensions from a group theory point of view. Several solutions can be constructed analytically and are determined by the embeddings of three dimensional simple Lie groups into G, in a generic irreducible representation. These solutions represent the so-called nuclear pasta state configurations of nuclear matter at low energy. We employ the Dynkin explicit classification of all three dimensional Lie subgroups of exceptional Lie group to classify all such solutions in the case G is an exceptional simple Lie group, and give all ingredients to construct them explicitly. As an example, we construct the explicit solutions for G=G2. We then extend our ansatz to include the minimal coupling of the Skyrme field to a U(1) gauge field. We extend the definition of the topological charge to this case and then concentrate our attention to the electromagnetic case. After imposing a \u201cfree force condition\u201d on the gauge field, the complete set of coupled field equations corresponding to the gauged Skyrme model minimally coupled to an Abelian gauge field is reduced to just one linear ODE keeping alive the topological charge. We discuss the cases in which such ODE belongs to the (Whittaker-)Hill and Mathieu types

Autoimmune mucocutaneous blistering diseases after SARS-Cov-2 vaccination: A Case report of Pemphigus Vulgaris and a literature review

Background: Cases of severe autoimmune blistering diseases (AIBDs) have recently been reported in association with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Aims: To describe a report of oropharyngeal Pemphigus Vulgaris (OPV) triggered by the mRNABNT162b2 vaccine (Comirnaty®/ Pfizer/ BioNTech) and to analyze the clinical and immunological characteristics of the AIBDs cases reported following the SARS-CoV-2 vaccination. Methods: The clinical and immunological features of our case of OPV were documented. A review of the literature was conducted and only cases of AIBDs arising after the SARS-CoV-2 vaccination were included. Case report: A 60-year old female patients developed oropharyngeal and nasal bullous lesions seven days after the administration of a second dose of the mRNABNT162b2 vaccine (Comirnaty®/ Pfizer/BioNtech). According to the histology and direct immunofluorescence findings showing the presence of supra-basal blister and intercellular staining of IgG antibodies and the presence of a high level of anti-Dsg-3 antibodies (80 U/ml; normal < 7 U/ml) in the serum of the patients, a diagnosis of oropharyngeal Pemphigus Vulgaris was made. Review: A total of 35 AIBDs cases triggered by the SARS-CoV-2 vaccination were found (including our report). 26 (74.3%) were diagnosed as Bullous Pemphigoid, 2 (5.7%) as Linear IgA Bullous Dermatosis, 6 (17.1%) as Pemphigus Vulgaris and 1 (2.9%) as Pemphigus Foliaceus. The mean age of the sample was 72.8 years and there was a predominance of males over females (F:M=1:1.7). In 22 (62.9%) cases, the disease developed after Pfizer vaccine administration, 6 (17.1%) after Moderna, 3 (8.6%) after AstraZeneca, 3 (8.6%) after CoronaVac (one was not specified). All patients were treated with topical and/or systemic corticosteroids, with or without the addition of immunosuppressive drugs, with a good clinical response in every case. Conclusion: Clinicians should be aware of the potential, though rare, occurrence of AIBDs as a possible adverse event after the SARS-CoV-2 vaccination. However, notwithstanding, they should encourage their patients to obtain the vaccination in order to assist the public health systems to overcome the COVID-19 pandemic

Statin‐induced myopathy: Translational studies from preclinical to clinical evidence

Statins are the most prescribed and effective drugs to treat cardiovascular diseases (CVD). Nevertheless, these drugs can be responsible for skeletal muscle toxicity which leads to reduced compliance. The discontinuation of therapy increases the incidence of CVD. Thus, it is essential to assess the risk. In fact, many studies have been performed at preclinical and clinical level to investigate pathophysiological mechanisms and clinical implications of statin myotoxicity. Consequently, new toxicological aspects and new biomarkers have arisen. Indeed, these drugs may affect gene transcription and ion transport and contribute to muscle function impairment. Identifying a marker of toxicity is important to prevent or to cure statin induced myopathy while assuring the right therapy for hypercholesterolemia and counteracting CVD. In this review we focused on the mechanisms of muscle damage discovered in preclinical and clinical studies and high-lighted the pathological situations in which statin therapy should be avoided. In this context, preventive or substitutive therapies should also be evaluated

A new generation photodetector for astroparticle physics: the VSiPMT

The VSiPMT (Vacuum Silicon PhotoMultiplier Tube) is an innovative design we proposed for a revolutionary photon detector. The main idea is to replace the classical dynode chain of a PMT with a SiPM (G-APD), the latter acting as an electron detector and amplifier. The aim is to match the large sensitive area of a photocathode with the performance of the SiPM technology. The VSiPMT has many attractive features. In particular, a low power consumption and an excellent photon counting capability. To prove the feasibility of the idea we first tested the performance of a special non-windowed SiPM by Hamamatsu (MPPC) as electron detector and current amplifier. Thanks to this result Hamamatsu realized two VSiPMT industrial prototypes. In this work, we present the results of a full characterization of the VSiPMT prototype