Optimum plastic design of tapered gable frames

This study deals with the problem of plastic analysis and design of symmetrical tapered or uniform gable frames of the portal type subject to usual loads. In the course of this study, a fully automatic plastic design procedure, based on an original conversational computer program written by H. B. Harrison, was developed and implemented on the UNIVAC 1108 computer. Input data was made free-format in order to eliminate the inconvenience present in using a fixed-format input. Another new feature of the program is the capability of dealing with tapered-column gable frames. The procedure for analysis and design in the modified program accounts for the strength reduction in the plastic moment capacity caused by the presence of axial thrust in the frame members. The program also checks for the limiting width-to-thickness ratios of web and flange as given by the 1971 AISC specifications which serve to prevent local buckling failures.Civil and Environmental Engineering, Department o

S100A10, a novel biomarker in pancreatic ductal adenocarcinoma

Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome and quality of life. Here, we introduce the plasminogen receptor S100A10 as a novel predictive biomarker and a driver of pancreatic tumor growth and invasion. We demonstrated that S100A10 mRNA and protein are overexpressed in human pancreatic tumors compared to normal ducts and nonductal stroma. S100A10 mRNA and methylation status were predictive of overall survival and recurrence‐free survival across multiple patient cohorts. S100A10 expression was driven by promoter methylation and the oncogene KRAS. S100A10 knockdown reduced surface plasminogen activation, invasiveness, and in vivo growth of pancreatic cancer cell lines. These findings delineate the clinical and functional contribution of S100A10 as a biomarker in pancreatic cancer