A Fishery Manager's Guidebook, Second Edition

A Fishery Managers' Guidebook was first published as an FAO Fisheries Technical Paper in 2002 to meet the need for information and guidance on the broad and often complex task of fisheries management. Based on subsequent experience and feedback gained from publication of the first edition, this new volume, has been expanded to provide broader coverage of the key elements of the task and updated in order to keep track of the rapid developments in theory and practice as academics and practitioners struggle to confront the many challenges facing modern fisheries management

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Background: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. Methods: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. Findings: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52–1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03–4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [<1%], adjusted OR 5·58 [1·22–25·50]; p=0·024). Interpretation: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. Funding: None

Le choix d'une société

[eng] The choice of a society - Farmers in post-war years have had to face a sharp alternative — either to adopt « progress », new production methods and a new way of life, or to disappear altogether in the near future. In the 70's many farmers who had adopted progress to survive and who had been caught up in the workings of the national economy gradually became aware of their precarious economic situation in spite of their attempts to adapt and modernize. Today they have to try to survive progress. The farmer has lost his traditional « peasant » identity and village society has crumbled before society at large. We must now reconsider the present role of farming in society as a whole and whether an original local society can survive. [fre] Les agriculteurs, dans les années d'après guerre, ont dû faire face à une sévère alternative : adopter le « progrès » c'est-à-dire de nouveaux modes de production et de vie ou, à plus ou moins brève échéance, disparaître. Dans les années 1970, après avoir adopté le progrès pour survivre et s'être intégré dans les rouages de l'économie nationale, bon nombre d'agriculteurs ont pris conscience de la précarité de leur situation économique malgré leurs efforts d'adaptation et de modernisation ; il faut aujourd'hui tenter de survivre au progrès. L'agriculteur a perdu son identité traditionnelle « de paysan » et la société villageoise s'est effritée sous les assauts de la société globale. Nous sommes amenés à nous interroger sur la place nouvelle de l'agriculteur dans la société nationale et sur les conditions de survie d'une société locale originale.

Les enseignements de la psycho sociologie en matière de diffusion des innovations. Discussion par Ch. Delaunoy

Bodiguel M. Les enseignements de la psycho sociologie en matière de diffusion des innovations. Discussion par Ch. Delaunoy. In: Économie rurale. N°99-100, 1974. Le développement agricole en France. pp. 133-136

Axisymmetric Drainage in Hydrophobic Porous Media Micromodels

We present studies of axisymmetric drainage in two-dimensional micromodels of porous media using up to date microfabrication and image analysis methods. Drainage of model oil by aqueous solutions is studied at low capillary numbers (Ca) typically encountered during oil recovery operations. We use two types of oil-wet micromodels: one is based on a deposition method for creating a random monolayer of micronic glass beads, while the other is made using computer generated random networks etched in glass using wet-lithography. Both models have a central injection scheme and a radial geometry, resulting in a continuous variation of the capillary number during the course of drainage. We first carry out an analysis of experiments at global micromodel scale using computer based image analysis coupled with flow rates and pressure drop measurements. Basic relevant parameters such as permeability, porosity of the micromodel and residual oil in place after waterflooding are extracted. We then take advantage of the ease of observation in transparent micromodels to investigate the drainage phenomenon at local scale. Local saturation and front width are measured as a function of the local capillary number. Interestingly, because of the radial flow geometry, our experiments allow a continuous plotting of the micromodels capillary desaturation curve on several decades. As expected but never precisely observed, all points of various experiments collapse on a single capillary desaturation curve for a given micromodel. However, we observe dissimilar behaviors between the two types of micromodels. We discuss this phenomenon in light of the pore scale geometrical differences between the two models

A dynamic and mechanistic model of PCB bioaccumulation in the European hake (Merluccius merluccius)

Bioaccumulation is difficult to document because responses differ among chemical compounds, with environmental conditions. and physiological processes characteristic of each species. We use a mechanistic model, based on the Dynamic Energy Budget (DEB) theory, to take into account this complexity and study factors impacting accumulation of organic pollutants in fish through ontogeny. The bioaccumulation model proposed is a comprehensive approach that relates evolution of hake PCB contamination to physiological information about the fish, such as diet, metabolism, reserve and reproduction status. The species studied is the European hake (Merluccius merluccius, L 1758). The model is applied to study the total concentration and the lipid normalised concentration of 4 PCB congeners in male and female hakes from the Gulf of Lions (NW Mediterranean sea) and the Bay of Biscay (NE Atlantic ocean). Outputs of the model compare consistently to measurements over the life span of fish. Simulation results clearly demonstrate the relative effects of food contamination, growth and reproduction on the PCB bioaccumulation in hake. The same species living in different habitats and exposed to different PCB prey concentrations exhibit marked difference in the body accumulation of PCBs. At the adult stage, female hakes have a lower PCB concentration compared to males for a given length. We successfully simulated these sex-specific PCB concentrations by considering two mechanisms: a higher energy allocation to growth for females and a transfer of PCBs from the female to its eggs when allocating lipids from reserve to eggs. Finally, by its mechanistic description of physiological processes, the model is relevant for other species and sets the stage for a mechanistic understanding of toxicity and ecological effects of organic contaminants in marine organisms