9 research outputs found

    Membrane-Protein Binding Measured with Solution-Phase Plasmonic Nanocube Sensors

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    We describe a solution-phase sensor of lipid-protein binding based on localized surface plasmon resonance (LSPR) of silver nanocubes. When silica-coated nanocubes are mixed into a suspension of lipid vesicles, supported membranes spontaneously assemble on their surfaces. Using a standard laboratory spectrophotometer, we calibrate the LSPR peak shift due to protein binding to the membrane surface and then characterize the lipid-binding specificity of a pleckstrin-homology domain protein

    Gold nanoparticles with patterned surface monolayers for nanomedicine: current perspectives

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