Traffic monitoring using video analytics in clouds

Traffic monitoring is a challenging task on crowded roads. Traditional traffic monitoring procedures are manual, expensive, time consuming and involve human operators. They are subjective due to the very involvement of human factor and sometimes provide inaccurate/incomplete monitoring results. Large scale storage and analysis of video streams were not possible due to limited availability of storage and compute resources in the past. Recent advances in data storage, processing and communications have made it possible to store and process huge volumes of video data and develop applications that are neither subjective nor limited in feature sets. It is now possible to implement object detection and tracking, behavioural analysis of traffic patterns, number plate recognition and automate security and surveillance on video streams produced by traffic monitoring and surveillance cameras. In this paper, we present a video stream acquisition, processing and analytics framework in the clouds to address some of the traffic monitoring challenges mentioned above. This framework provides an end-to-end solution for video stream capture, storage and analysis using a cloud based GPU cluster. The framework empowers traffic control room operators by automating the process of vehicle identification and finding events of interest from the recorded video streams. An operator only specifies the analysis criteria and the duration of video streams to analyse. The video streams are then automatically fetched from the cloud storage, decoded and analysed on a Hadoop based GPU cluster without operator intervention in our framework. It reduces the latencies in video analysis process by porting its compute intensive parts to the GPU cluster. The framework is evaluated with one month of recorded video streams data on a cloud based GPU cluster. The results show a speedup of 14 times on a GPU and 4 times on a CPU when compared with one human operator analysing the same amount of video streams data

Atmospheric conditions of extreme precipitation events in western Turkey for the period 2006–2015

This paper investigates the precipitation types and background physical mechanisms of extreme precipitation events (EPEs) over western Turkey during the period 2006–2015. The EPEs are described as the precipitation values above the 90th percentile obtained from the hourly precipitation dataset, which has high spatial resolution. Precipitation types associated with EPEs are identified by using radar outputs and the Lamb weather type (LWT) approach. It is found that EPEs occurred more frequently in the Marmara and Aegean regions during autumn and winter months. In Marmara, mainly 21&thinsp;%, 17&thinsp;%, and 15&thinsp;% of total autumn EPEs show convective, cyclonic, and sea-effect precipitation characteristics, respectively. While convective EPEs are seen more commonly in the southern portions, cyclonic and sea-effect-originated EPEs mainly affect the southwest and northeastern parts of Marmara. Among these three precipitation types, convective mechanisms generally produce more intense daily precipitation (66.1&thinsp;mm on average) in the Marmara Region under the proper synoptic conditions (high-pressure center over the Balkan Peninsula and low-pressure center over the eastern Mediterranean). Based on the hourly observations, convective types of extreme precipitation (EP) show two peak values during afternoon and evening times of the day and are linked to diurnal heating. In terms of the Aegean Region, cyclone-originated EP, which includes 65&thinsp;% of the total winter EPEs, is more common in the whole territory and reaches its peak value during the early hours of the day.</p

Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration

Spinal cord injury (SCI) induces neurological deficits associated with long-term functional impairments. Since the current treatments remain ineffective, novel therapeutic options are needed. Besides its effect on bipolar mood disorder, lithium was reported to have neuroprotective activity in different neurodegenerative conditions, including SCI. In SCI, the effects of lithium on long-term neurological recovery and neuroplasticity have not been assessed. We herein investigated the effects of intraperitoneally administered lithium chloride (LiCl) on motor coordination recovery, electromyography (EMG) responses, histopathological injury and remodeling, and axonal plasticity in mice exposed to spinal cord transection. At a dose of 0.2, but not 2.0 mmol/kg, LiCl enhanced motor coordination and locomotor activity starting at 28 days post-injury (dpi), as assessed by a set of behavioral tests. Following electrical stimulation proximal to the hemitransection, LiCl at 0.2 mmol/kg decreased the latency and increased the amplitude of EMG responses in the denervated hindlimb at 56 dpi. Functional recovery was associated with reduced gray and white matter atrophy rostral and caudal to the hemitransection, increased neuronal survival and reduced astrogliosis in the dorsal and ventral horns caudal to the hemitransection, and increased regeneration of long-distance axons proximal and distal to the lesion site in mice receiving 0.2 mmol/kg, but not 2 mmol/kg LiCl, as assessed by histochemical and immunohistochemical studies combined with anterograde tract tracing. Our results indicate that LiCl induces long-term neurological recovery and neuroplasticity following SCI.TUBA ; Istanbul Medipol University ; Turkish Academy of Science

A Nutrigenetic approach to examine the relationship between vitamin B12 status and cardio-metabolic traits in multiple ethnic groups – findings from the GeNuIne Collaboration

Low vitamin B12 concentrations have been shown to be risk factors for metabolic traits in numerous observational studies; however, the relationship has remained inconsistent. It is possible that certain genotypes jointly contribute to obesity and vitamin B12 deficiency, and these may be modulated by dietary factors. The main objective of this review article was to summarize the effect of gene-nutrient interactions on vitamin B12 concentrations and cardio-metabolic disease risk factors using population-based studies from different ethnic groups from the GeNuIne (Gene-Nutrient Interactions) Collaboration. Interactions between vitamin B12-related SNPs and protein energy intake (%) on waist circumference (Pinteration=0.002) and body fat percentage (Pinteraction=0.034), were observed in Sri Lankan and Indonesian populations, respectively. In the study in Brazilian adolescents, the metabolic and vitamin B12 related SNPs showed a significant interaction with carbohydrate and protein intakes on oxidised low density lipoprotein cholesterol and homocysteine concentrations, respectively. In the Asian Indian population, an association between obesity-related SNPs and vitamin B12 concentrations (P = 0.018) was observed. In summary, these studies in multiple ethnic groups show that the association between genetically low vitamin B12 concentrations and metabolic outcomes may be modified by dietary intake. Further studies utilising larger sample sizes are needed to confirm or refute our findings

Padres Preparados, Jóvenes Saludables: intervention impact of a randomized controlled trial on Latino father and adolescent energy balance-related behaviors

Studies have shown associations among food and activity behaviors and body weight of Latino fathers and adolescents. However, few Latino father-focused interventions have been designed to improve energy balance-related behaviors (EBRBs) and weight status among early adolescents. Thus, this efficacy study aims to evaluate the Padres Preparados, Jóvenes Saludables (Padres) youth obesity prevention program for positive changes in EBRBs (fruit, vegetable, sugar-sweetened beverage (SSB), sweet/salty snack, and fast-food consumption, physical activity, and screen time) and weight status among low-income Latino fathers and adolescents (10-14 years). A two-arm (treatment versus delayed-treatment control group) randomized controlled trial was conducted to evaluate the efficacy of 8 weekly experiential learning sessions (2.5 hours each) based on social cognitive theory. The sessions included food preparation, parenting skills, nutrition, and physical activity. The program was delivered to father-adolescent dyads (mothers were encouraged to attend) in trusted community-based settings in a Midwest metropolitan area between 2017 and 2019. In March 2020, in-person implementation was discontinued due to COVID-19 pandemic restrictions, which limited the sample size. Father/adolescent dyads were randomized to treatment or control group within each site. Surveys and measurements were completed by fathers and adolescents to assess changes in food and activity behaviors from baseline to post-intervention. Adolescents also completed 24-hour dietary recall interviews at baseline and post-intervention. Intervention effects were assessed using linear regression mixed models adjusted for covariates and accounting for clustering of participants within sites. Data from 147 father/adolescent dyads who completed at least the baseline data collection were used. No significant differences were observed for baseline to post-intervention changes in adolescents’ and fathers’ EBRBs or weight status between treatment and control groups. Fathers’ SSB and fast food intakes were not statistically significant (p = 0.067 and p = 0.090, respectively). The Padres program resulted in no significant improvements in adolescent and father EBRBs and weight status. Additional Latino father-focused interventions are needed to examine intervention effects on EBRBs among Latino adolescents.https://doi.org/10.1186/s12889-022-14284-

Early-infantile onset epilepsy and developmental delay caused by bi-allelic GAD1 variants

Gamma-aminobutyric acid (GABA) and glutamate are the most abundant amino acid neurotransmitters in the brain. GABA, an inhibitory neurotransmitter, is synthesized by glutamic acid decarboxylase (GAD). Its predominant isoform GAD67, contributes up to ∼90% of base-level GABA in the CNS, and is encoded by the GAD1 gene. Disruption of GAD1 results in an imbalance of inhibitory and excitatory neurotransmitters, and as Gad1−/− mice die neonatally of severe cleft palate, it has not been possible to determine any potential neurological dysfunction. Furthermore, little is known about the consequence of GAD1 disruption in humans. Here we present six affected individuals from six unrelated families, carrying bi-allelic GAD1 variants, presenting with developmental and epileptic encephalopathy, characterized by early-infantile onset epilepsy and hypotonia with additional variable non-CNS manifestations such as skeletal abnormalities, dysmorphic features and cleft palate. Our findings highlight an important role for GAD1 in seizure induction, neuronal and extraneuronal development, and introduce GAD1 as a new gene associated with developmental and epileptic encephalopathy

Effects of dietary supplementation of nickel and nickel-zinc on femoral bone structure in rabbits

<p>Abstract</p> <p>Background</p> <p>Nickel (Ni) and zinc (Zn) are trace elements present at low concentrations in agroecosystems. Nickel, however, may have toxic effects on living organisms and is often considered as a contaminant. This study reports the effect of peroral administrated Ni or a combination of Ni and Zn on femoral bone structure in rabbits.</p> <p>Methods</p> <p>One month-old female rabbits were divided into three groups of five animals each. Group 1 rabbits were fed a granular feed mixture with addition of 35 g NiCl₂per 100 kg of mixture for 90 days. In group 2, animals were fed a mixture containing 35 g NiCl₂and 30 g ZnCl₂per 100 kg of mixture. Group 3 without administration of additional Ni or Zn served as control. After the 90-day experimental period, femoral length, femoral weight and histological structure of the femur were analyzed and compared.</p> <p>Results</p> <p>The results did not indicate a statistically significant difference in either femoral length or weight between the two experimental groups and the control group. Also, differences in qualitative histological characteristics of the femora among rabbits from the three groups were absent, except for a fewer number of secondary osteons found in the animals of groups 1 and 2. However, values for vascular canal parameters of primary osteons were significantly lower in group 1 than in the control one. Peroral administration of a combination of Ni and Zn (group 2) led to a significant decreased size of the secondary osteons.</p> <p>Conclusions</p> <p>The study indicates that dietary supplementation of Ni (35 g NiCl₂per 100 kg of feed mixture) and Ni-Zn combination (35 g NiCl₂and 30 g ZnCl₂per 100 kg of the mixture) affects the microstructure of compact bone tissue in young rabbits.</p

Metallothionein – overexpression as a highly significant prognostic factor in melanoma: a prospective study on 1270 patients

Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined the role of MT overexpression in melanoma patients as a prognostic factor for progression and survival. Between 1993 and 2004, 3386 patients with primary cutaneous melanoma were investigated by using a monoclonal antibody against MT on routinely fixed, paraffin-embedded tissues. In all, 1270 patients could be followed up for further statistical analysis (Fisher's exact test, Mantel–Haenszel χ2 test, Kaplan–Meier curves). The MT data of disease-free interval and overall survival were compared univariately and multivariately in Cox regression analysis. Immunohistochemical overexpression of MT in tumour cells of patients with primary melanoma (310 of 1270; 24.4%) was associated with a higher risk for progression (117 of 167; 70.1%) and reduced survival (80 of 110; 72.7%) of the disease (P<0.0001). Similarly, Kaplan–Meier curves gave highly significant disadvantages for the MT-positive group. Univariate analysis (relative risk 7.4; 95% confidence interval (CI) 5.2–10.2; P<0.0001 for progression; relative risk 7.1; 95% CI 4.7–10.9; P<0.0001 for survival), as well as multivariate analysis with other prognostic markers resulted in MT overexpression as a highly significant and independent factor for prognosis in primary melanoma