A study on the sense of attachment, with a phenomenological view of place: Interpretation of people’s existential experiences

Place and the sense of attachment to a place are among the topics that are considered in this study in which people are shown to have internal relationship with the environment. In fact, the feeling of belonging and attachment to a place play a decisive role in any situation and space, in order to benefit and maintain human presence there. This sense leads to the connection in such a way that man considers himself as a part of the place. The spatial attachment is a relationship of belonging and identity to the environment in which one lives. For this reason, the purpose of this study is to achieve the effective factors in the formation of a sense of attachment, by recognizing the characteristics of the place. This research is qualitative in nature and is conducted with an existential phenomenological approach in which three types of informal (conversational) and semi-structured interviews and in-depth (structured) interviews are used as data tools. Findings show that two categories of factors can be effective in the sense of attachment of residents to the house: external dialectic and factors that are related to the outside of the house (i.e., the quality of the exterior appearance of the house; neighborhood reputation and security) and internal dialectics factors that are related to inside (i.e. ownership; quality of comfort; physical quality of the house; neighborhood satisfaction and positive emotional relationships). These two categories influence the formation of residents' attachment to house i.e. "human-house interaction" and have been identified as the core of research. In the phenomenological approach, the sense of belonging means the inter-relationship between human and the environment, which includes all indicators

Cultural and livelihood impacts on the physical and biolospatial formation of traditional houses in Paveh

Native design of buildings is a branch of architecture based on local needs and available materials that reflect regional traditions. The city of Paveh in the northwestern Iranian province of Kermanshah has many valuable buildings, with some dating back to more than three thousand years which are stepped-type based the topography of the land. The purpose of this research is to investigate the impact of culture and livelihood on the physical and biological space formation of traditional houses in Paveh. Data were collected through measuring livelihood standard, geographical location, and type of materials, culture and environmental factors through observation method in spring 2023 and based on questionnaire as a tool. The data analysis was done through factor analysis and regression tests with Lisrel and SPSS software. Validation of the questionnaire was confirmed through content validity and its reliability was checked through Cronbach alpha (r=0.701). By confirmatory analysis, research components with a factor load above 0.4 were identified and confirmed. The ADJR2 index in the regression test showed that the research indicators predict 61% of the physical and biospatial variance of the traditional houses in Paveh. The component of culture and climate has the highest influence (beta=0.779) on the physical and spatial formation of traditional houses there. The results obtained from the observation method also showed that the cultural, social, religious, livelihood features include the use of natural materials, spatial hierarchy, proper separation of spaces, building houses on top or next to each other and paying attention to the environment, including the correct orientation, the use of brick laying, the appropriate dimensions of the openings, etc. which have been the most important factors in bodily and spatial formation of houses in Paveh

Investigating the Relationship between of Vascular Endothelial Growth Factor and HER-2neu in IHC Staining with Metastasis and Mortality in Patients with Osteosarcoma

Background: The expression of HER-2neu and vascular endothelial growth factor (VEGF) in patients with osteosarcoma may determine the response to treatment. These two factors are likely to be effective in cancer progression. This study aimed at investigating the prevalence of these two factors in the pathological samples. Methods: Pathological samples of patients with osteosarcoma collected at a cancer surgery center between 2017 and 2018 were evaluated, of which 37 samples were included. The samples were evaluated using the IHC technique by two pathologists. Results: 12 women and 25 men with an average age of 26.7 years were studied. 21 patients (56.8) developed metastases from the beginning or during follow-up, whereas 16 patients (43.2) have not yet developed metastases. Regarding HER-2neu, 21 patients (56.8) scored 0, 9 patients (24.3) scored 1, 3 patients (8.1) scored +2, and 4 patients (10.8) scored +3. The VEGF intensity scores of 0, 1+, 2+, +3, +4 and were found in 7 (18.9), 2 (5.4), 18 (48.6), 8 (21.6), and 2 (5.4) patients, respectively. The results of the study did not show a significant relationship between age, gender, metastasis, and positive expression rates of HER-2neu and VEGF. Conclusion: The high expression of VEGF (75.7) in the studied samples should be considered and further studies on this biomarker in cases with osteosarcoma are recommended from different aspects. To achieve validated results and prove the results of this study, similar studies with a larger sample size should be performed, and using targeted therapy for angiogenesis in large scale trials should be considered