Peculiarities in produced particles emission in 208Pb + Ag(Br) interactions at 158 A GeV/c

The angular structures of particles produced in 208Pb induced collisions with Ag(Br) nuclei in an emulsion detector at 158 A GeV/c have been investigated. Nonstatistical ring-like substructures in azimuthal plane of the collision have been found and their parameters have been determined. The indication on the formation of the ring-like substructures from two symmetrical emission cones - one in the forward and other in the backward direction in the center-of mass system have been obtained. The ring-like substructures parameters have been determined. The experimental results are in an agreement with I.M. Dremin idea, that mechanism of the ring-like substructures formation in nuclear collisions is similar to that of Cherenkov electromagnetic radiation.Comment: 10 pages, 7 figures, Report at the HADRON STRUCTURE'04 Conference, Smolenice, Slovakia, 30.8.-3.9.200

Unraveling the Pharmacokinetic Interaction of Ticagrelor and MEDI2452 (Ticagrelor Antidote) by Mathematical Modeling

The investigational ticagrelor-neutralizing antibody fragment, MEDI2452, is developed to rapidly and specifically reverse the antiplatelet effects of ticagrelor. However, the dynamic interaction of ticagrelor, the ticagrelor active metabolite (TAM), and MEDI2452, makes pharmacokinetic (PK) analysis nontrivial and mathematical modeling becomes essential to unravel the complex behavior of this system. We propose a mechanistic PK model, including a special observation model for post-sampling equilibration, which is validated and refined using mouse in vivo data from four studies of combined ticagrelor-MEDI2452 treatment. Model predictions of free ticagrelor and TAM plasma concentrations are subsequently used to drive a pharmacodynamic (PD) model that successfully describes platelet aggregation data. Furthermore, the model indicates that MEDI2452-bound ticagrelor is primarily eliminated together with MEDI2452 in the kidneys, and not recycled to the plasma, thereby providing a possible scenario for the extrapolation to humans. We anticipate the modeling work to improve PK and PD understanding, experimental design, and translational confidence

A Relational Event Approach to Modeling Behavioral Dynamics

This chapter provides an introduction to the analysis of relational event data (i.e., actions, interactions, or other events involving multiple actors that occur over time) within the R/statnet platform. We begin by reviewing the basics of relational event modeling, with an emphasis on models with piecewise constant hazards. We then discuss estimation for dyadic and more general relational event models using the relevent package, with an emphasis on hands-on applications of the methods and interpretation of results. Statnet is a collection of packages for the R statistical computing system that supports the representation, manipulation, visualization, modeling, simulation, and analysis of relational data. Statnet packages are contributed by a team of volunteer developers, and are made freely available under the GNU Public License. These packages are written for the R statistical computing environment, and can be used with any computing platform that supports R (including Windows, Linux, and Mac).

Decolonizing the Mind with Ngugi Wa Thiong\u27o and Chinua Achebe: Searching for a Voice in Postcolonial African Literature

Any discussion of postcolonial African literature requires consideration of both the inherent diversity of “African” and the complex history of colonialism throughout Africa. Ngugi wa Thiong’o claims there are “broad affinities” among the diverse peoples of sub-Saharan Africa which allow for a broad discussion of the common experiences of colonialism, but it is necessary to complement these broad affinities with specific cultural references and historic contexts. This paper attempts to delineate some of the common struggles facing postcolonial African peoples by focusing on the specific writings of Kenya’s Ngugi wa Thiong’o and Nigeria’s Chinua Achebe. Though they are from disparate regions within Africa, Ngugi and Achebe share the common experiences of being subjects to British colonial rule and, later, of witnessing the births of their respective nations. From their common experiences, several key issues pertaining to postcolonial literature emerge, namely the political and cultural implications of retaining English as the lingua franca in an independent African nation. The debates concerning the role of English in postcolonial African nations inspires serious consideration of the relationship between a language and its people, the relevance of a language to cultural identity, and, as the Alice Walker discussion willdemonstrate, the ideological conflict between cultural autonomy and cultural chauvinism. A close analysis of the primary works of Ngugi wa Thiong’o and Chinua Achebe reveals a political imperative from each author. Exploring this relationship between literature and politics, this paper will attempt to present and then address several of the key political issues portrayed by Ngugi and Achebe. To complement these primary works, the paper employs additional secondary sources to help develop a conceptual framework through which Ngugi and Achebe can be read and interpreted. This paper will not pretend to be exhaustive in exploring the many serious issues facing postcolonial African peoples, and it will not presume to solve the issues it does address. Rather, this study provides a starting point for understanding the dynamics of two of Africa’s leading contemporary writers and thinkers-Ngugi wa Thiong’o and Chinua Achebe-and a forum for addressing the complexity inherent to the postcolonial discussion itsel

Evaluation of rate law approximations in bottom-up kinetic models of metabolism.

BackgroundThe mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters. The parameterization challenge is often addressed through the use of simplifying approximations to form reaction rate laws with reduced numbers of parameters. Whether such simplified models can reproduce dynamic characteristics of the full system is an important question.ResultsIn this work, we compared the local transient response properties of dynamic models constructed using rate laws with varying levels of approximation. These approximate rate laws were: 1) a Michaelis-Menten rate law with measured enzyme parameters, 2) a Michaelis-Menten rate law with approximated parameters, using the convenience kinetics convention, 3) a thermodynamic rate law resulting from a metabolite saturation assumption, and 4) a pure chemical reaction mass action rate law that removes the role of the enzyme from the reaction kinetics. We utilized in vivo data for the human red blood cell to compare the effect of rate law choices against the backdrop of physiological flux and concentration differences. We found that the Michaelis-Menten rate law with measured enzyme parameters yields an excellent approximation of the full system dynamics, while other assumptions cause greater discrepancies in system dynamic behavior. However, iteratively replacing mechanistic rate laws with approximations resulted in a model that retains a high correlation with the true model behavior. Investigating this consistency, we determined that the order of magnitude differences among fluxes and concentrations in the network were greatly influential on the network dynamics. We further identified reaction features such as thermodynamic reversibility, high substrate concentration, and lack of allosteric regulation, which make certain reactions more suitable for rate law approximations.ConclusionsOverall, our work generally supports the use of approximate rate laws when building large scale kinetic models, due to the key role that physiologically meaningful flux and concentration ranges play in determining network dynamics. However, we also showed that detailed mechanistic models show a clear benefit in prediction accuracy when data is available. The work here should help to provide guidance to future kinetic modeling efforts on the choice of rate law and parameterization approaches

Parton cascade description of relativistic heavy-ion collisions at CERN SPS energies ?

We examine Pb+Pb collisions at CERN SPS energy 158 A GeV, by employing the earlier developed and recently refined parton-cascade/cluster-hadronization model and its Monte Carlo implementation. This space-time model involves the dynamical interplay of perturbative QCD parton production and evolution, with non-perturbative parton-cluster formation and hadron production through cluster decays. Using computer simulations, we are able to follow the entwined time-evolution of parton and hadron degrees of freedom in both position and momentum space, from the instant of nuclear overlap to the final yield of particles. We present and discuss results for the multiplicity distributions, which agree well with the measured data from the CERN SPS, including those for K mesons. The transverse momentum distributions of the produced hadrons are also found to be in good agreement with the preliminary data measured by the NA49 and the WA98 collaboration for the collision of lead nuclei at the CERN SPS. The analysis of the time evolution of transverse energy deposited in the collision zone and the energy density suggests an existence of partonic matter for a time of more than 5 fm.Comment: 16 pages including 7 postscript figure

Relativistic Heavy--Ion Collisions in the Dynamical String--Parton Model

We develop and extend the dynamical string parton model. This model, which is based on the salient features of QCD, uses classical Nambu-Got\=o strings with the endpoints identified as partons, an invariant string breaking model of the hadronization process, and interactions described as quark-quark interactions. In this work, the original model is extended to include a phenomenological quantization of the mass of the strings, an analytical technique for treating the incident nucleons as a distribution of string configurations determined by the experimentally measured structure function, the inclusion of the gluonic content of the nucleon through the introduction of purely gluonic strings, and the use of a hard parton-parton interaction taken from perturbative QCD combined with a phenomenological soft interaction. The limited number of parameters in the model are adjusted to $e^+e^-$ and $p$--$p$ data. Utilizing these parameters, the first calculations of the model for $p$--$A$ and $A$--$A$ collisions are presented and found to be in reasonable agreement with a broad set of data.Comment: 26 pages of text with 23 Postscript figures placed in tex