Revamping established project procurement approaches to support BIM implementation

Purpose Previous studies have established to a great extent that regulatory frameworks and, in particular, procurement approaches – that are common in a particular context – have a major impact on the success of building information modelling (BIM) implementation in construction projects. Despite the close links between these two concepts, research on the effect of procurement approaches on BIM implementation is scarce. To address this gap, this paper aims to investigate the barriers that affect BIM implementation through the lens of procurement approaches. Design/methodology/approach A mixed-method approach was adopted using a questionnaire survey (n = 116) and interviews with key stakeholders (n = 12) in Jordan. The outcomes of the quantitative parts were augmented with findings from interviews. Findings It was revealed that the deployment of unfavourable construction procurement approaches represents a major hurdle towards BIM implementation. Though essential for enhancing BIM implementation, it is revealed that a fundamental change from the common design-bid-build (DBB) to more collaborative procurement approaches remains infeasible in view of the realities that govern the construction industry. Research limitations/implications It was revealed the deployment of unfavourable construction procurement approaches represents a major hurdle towards BIM implementation. Though essential for enhancing BIM implementation, it is revealed that a fundamental change from the common DBB to more collaborative procurement approaches remains infeasible given the realities that govern the construction industry. Originality/value As the first of its kind, a set of recommendations for establishing supportive, workable procurement that does not deviate significantly from common procedures and practices is presented. Rather than advocating a shift to procurement approaches that are aligned with BIM, the findings offer novel insight into the necessity of developing a framework within the boundaries of the current and widely adopted procurement approaches to address the identified construction procurement issues and facilitate BIM implementation

Time-resolved pharmacological studies using automated, on-line monitoring of five parallel suspension cultures

Early stage pharmacological studies rely on in vitro methodologies for screening and testing compounds. Conventional assays based on endpoint measurements provide limited information because the lack in temporal resolution may not determine the pharmacological effect at its maximum. We developed an on-line, automated system for near real-time monitoring of extracellular content from five parallel suspension cultures, combining cell density measurements with a high-resolution separations every 12 minutes for 4 days. Selector and switching valves provide the fluidic control required to sample from one culture during the analysis of the previous sample from another culture, a time-saving measure that is fundamental to the throughput of the presented system. The system was applied to study the metabolic effects of the drugs rotenone, β-lapachone and clioquinol using lactate as metabolic indicator. For each drug, 96 assays were executed on the extracellular matrix at three concentrations with two controls in parallel, consuming only 5.78 mL of media from each culture over four days, less than 60 μL per analysis. The automated system provides high sample throughput, good temporal resolution and low sample consumption combined with a rugged analytical method with adequate sensitivity, providing a promising new platform for pharmacological and biotechnological studies

Benefits of Implementing Occupational Health and Safety Management Systems for the Sustainable Construction Industry: A Systematic Literature Review

Accidents are more prevalent in the construction industry compared to other economic sectors. Therefore, understanding the benefits of occupational health and safety management systems (OHSMSs) in terms of their sustainable implementation, management and performance, as well as the awareness of OHMSs and barriers to their implementation, are important for improving OHSMSs in the sustainability of the construction industry. Although there is considerable research on OHSMSs, further assessments are needed concerning other aspects of OHSMSs, particularly the benefits of OHSMSs. Thus, this review paper summarises the empirical state of the art of OHSMS activities. Scopus, Web of Science and other databases were searched using predefined standards. The query was limited to articles published from 1999 to 2023. Consequently, one hundred and four articles were selected and analysed. These articles present analyses of OHSMSs and their potential benefits concerning the implementation of OHSMSs and management, performance, awareness, and barriers in relation to OHSMSs. The results reveal that 12.50% of the reviewed studies assessed the implementation of OHSMSs in the construction industry, and 25.96% studied the management of OHSMSs. Analyses of the performance of OHSMSs in the construction industry accounted for 8.65%, analyses of the awareness of OHSMSs accounted for 4.81%, model-related analyses accounted for 13.46%, studies on the significance/benefits of OHSMSs accounted for 3.85%, studies on the barriers/challenges associated with OHSMSs accounted for 5.77%, analyses on the safety indicators of OHSMSs accounted for 2.88% and other types of studies accounted for 20.19%. This study further reveals that the implementation of OHSMSs is characterised by a dearth of proper communication, the non-utilisation of personal protective equipment (PPE), wrong postures and work activities, a dearth of training, physiological factors including burnout and stress, and a dearth of safety culture and orientation; in addition, matters relating to compliance with effective laws are significant safety challenges in the construction industry. However, the rationality for evaluating the benefits of OHSMSs, comprising their implementation, management and performance, as well as awareness of and barriers to OHSMSs, is challenging to authenticate because appropriate field, survey, organisational and clinical data concerning incident occurrences in the construction industry are lacking for comprehensive evaluations. Thus, this novel study presents our effort to narrow this gap by establishing a framework for increasing our understanding of the benefits of implementing OHSMSs and accident reduction

A holistic multi evidence approach to study the fragmentation behaviour of crystalline mannitol

Mannitol is an essential excipient employed in orally disintegrating tablets due to its high palatability. However its fundamental disadvantage is its fragmentation during direct compression, producing mechanically weak tablets. The primary aim of this study was to assess the fracture behaviour of crystalline mannitol in relation to the energy input during direct compression, utilising ball milling as the method of energy input, whilst assessing tablet characteristics of post-milled powders. Results indicated that crystalline mannitol fractured at the hydrophilic (011) plane, as observed through SEM, alongside a reduction in dispersive surface energy. Disintegration times of post-milled tablets were reduced due to the exposure of the hydrophilic plane, whilst more robust tablets were produced. This was shown through higher tablet hardness and increased plastic deformation profiles of the post-milled powders, as observed with a lower yield pressure through an out-of-die Heckel analysis. Evaluation of crystal state using x-ray diffraction/differential scanning calorimetry showed that mannitol predominantly retained the β-polymorph; however x-ray diffraction provided a novel method to calculate energy input into the powders during ball milling. It can be concluded that particle size reduction is a pragmatic strategy to overcome the current limitation of mannitol fragmentation and provide improvements in tablet properties