Challenges in the diagnosis and treatment of peritoneal mesothelioma: a case study and review of the literature

Peritoneal mesothelioma is a rare neoplasm that is associated with multiple diagnostic and therapeutic challenges. Therapeutic guidelines are scarce and based on extrapolative data. Histopathological diagnosis is difficult as neither the morphological finding nor the immunohistochemical stains are specific. The mainstay treatment for resectable disease is cytoreductive surgery with intraperitoneal chemotherapy being a valuable addition. Treatment of non-resectable cases includes platinum-based chemotherapy, immune checkpoint inhibitors, and bevacizumab. We present a case of a 49-year-old woman suffering from inoperable peritoneal mesothelioma, which was initially diagnosed as ovarian cancer and treated accordingly

Numerical simulation of thermally loaded aircraft engine turbine blade covered with thermal barrier coating - TBC

The objective of this thesis is to present the impact of the turbine blade cooling on blade material temperature as well as to assess advantages and disadvantages of applied cooling method (TBC coating combined with internal cooling). To calculate the conjugated heat transfer analysis generating 3d model and mesh of the blade and its cooling was required. Model mesh was covered with boundary layer in order to properly simulate conditions near the blade walls and obtain accurate results. Calculated blade was put in the canal simulating hot combustion gasses flow. Geometry of model described above was created using Unigraphics NX5 program based on drawings obtained from available literature, and data acquired from the Internet. The discretization was done in commercial pre--processor GAMBITŽ. Conjugated heat transfer analysis was conducted in program FLUENTŽ for two different cases, where the TBC material properties were changed. The goal of this thesis was to obtain temperature fields and distribution in the turbine blade airfoil and to evaluate if applied cooling is sufficient to cool down this thermally loaded part of the engine. Calculated results show that proposed blade heat protection with TBC and internal cooling canal is insufficient during steady state condition, especially on the blade leading and trailing edge. In these two locations, the TBC coating is overheated, and the high temperature level of blade material is unacceptable for materials used in jet engine turbine industry

Magnetic Specific Heat Study of the Competition between Ferro- and Antiferromagnetic Spin-Spin exchange Interactions in PbSnMnTe

Magnetic contribution to the specific heat, magnetic susceptibility and Hall effect are experimentally studied in Pb$\text{}_{1-x-y}$Sn$\text{}_{y}$Mn$\text{}_{x}$Te semimagnetic semiconductors with y=0.72 and x=0.08 and with different carrier concentrations 10$\text{}^{20}$ ≤ p ≤ 10$\text{}^{21}$ cm$\text{}^{-3}$. The ferromagnetism observed in crystals with p ≥ 3×10$\text{}^{20}$ cm$\text{}^{-3}$ breaks down with a decreasing concentration of carriers due to an increasing competition between Ruderman-Kittel-Kasuya-Yoshida and superexchange interactions

Transport and Magnetic Properties of Pb1−x−y\text{}_{1-x-y}Sny\text{}_{y}Mnx\text{}_{x}Te (x ≤ 0.16)

Hall constant, conductivity and magnetic susceptibility of Pb$\text{}_{1-x-y}$Sn$\text{}_{y}$Mn$\text{}_{x}$Te semimagnetic semiconductor were investigated as a function of Mn content (x = 0.04, 0.09, 0.16, y = (0.7-0.8)) in the temperature range T = (4 - 300) K. A ferromagnetic phase transition takes place at T = 5 K for samples with x = 0.04, at T = 10 K for x = 0.09 and at T = 20 K for x = 0.16. For crystals with x ≥ 0.09 the strong temperature dependence of the Hall constant is observed for temperatures below 40 K. Magnetic field characteristics of the Hall effect is strongly non-linear at T = 4.2 K. No significant temperature or magnetic field dependence of conductivity is observed in the whole temperature range studied. The observed transport anomalies are due to the anomalous Hall effect

Transport and Magnetic Study of Gd Ions in Pb1−y\text{}_{1-y}Sny\text{}_{y}Te

Electric conductivity, Hall effect and magnetic susceptibility of Pb$\text{}_{1-x-y}$ Sn$\text{}_{y}$Gd$\text{}_{x}$Te mixed crystals with 0.13 ≤ y ≤ 0.93 and 0.001 ≤ x ≤ 0.04 were experimentally studied over the temperature range 4K ≤ T ≤ 300 K. The incorporation of Gd ions into the Pb$\text{}_{1-y}$Sn$\text{}_{y}$Te matrix results in semi-metallic n-type conductivity of the crystals with y 0.6 one observes only semi-metallic p-type conductivity. We present a model explaining these results in terms of the Sn composition dependence of the location of Gd$\text{}^{2+}\text{}^{/}\text{}^{3+}$ level with respect to the band edges of PbSnGdTe