Numerical modelling of the optical demultiplexer photonic structures

Photonic structures and their application are one of the most intensively studied areas of modern optics. They are used in devices such as blue lasers, optical fibres or optical add-drop multiplexers. The paper describes the possibility of designing the photonic structure of the optical demultiplexer using the application written by the authors

Treatment of advanced lung cancer by external beam radiotherapy and high dose rate (HDR) brachytherapy

PurposeBrachytherapy is a highly valued and effective palliative treatment for lung cancer, especially as it reduces intensity of dyspnoea and other symptoms arising from tumours inside the respiratory tract. In some cases, due to the location of the lesion brachytherapy is a treatment of choice. However, its curative role is unclear. A combination treatment of brachytherapy and an external beam irradiaton may play a significant role when the mediastinal lymph nodes are involved.The paper presents the results of treatment of advanced lung cancer patients by external beam irradiation and brachytherapy, and the role of this palliative treatment is discussed.Material and methodsBetween May 1999 and March 2000 at the Greatpoland Cancer Centre fifteen patients with advanced lung cancer were treated by HDR brachytherapy and palliative external beam irradiation using the method of hypofractionation. The patients’ age ranged between 39 to 80 years, mean: 54.3 years. The treatment consisted of external beam irradiation (total dose of 20–30 Gy), and a weekly high dose rate (HDR) brachytherapy (three fractions of 7.5 or 10 Gy, at 1 cm from the source). In three cases the treatment was started with external irradiation, whereas in 12 cases the first stage was brachytherapy. During the patients’ clinical and endobronchial follow-up of 1, 3 and 6 months, local remission and regression of difficulties in breathing, cough, pain and haemoptysis were assessed.ResultsIn all our patients subjective improvement (regression of all symptoms) was found on the first check-up following treatment. In one case complete remission of the tumour lasted for over 6 months, in 9 cases partial remission and in two cases progression were found. Severe complications due to the high total local dose were not observed.ConclusionsCombined palliative treatment (intraluminal brachytherapy and external beam irradiation) in advanced lung cancer was an efficient method that led to regression of symptoms and improvement of well-being in many patients

High dose rate endobronchial brachytherapy in the management of advanced lung cancer – comparison of different doses – preliminary assessment

PurposeBrachytherapy is one of the most efficient methods of overcoming endobronchial obstruction in palliative treatment of lung cancer. In single cases, brachytherapy is performed as radical treatment, however in most of cases, due to advanced clinical stage it has a palliative aim. In the absence of clear consensus regarding the value of doses used in brachytherapy different fraction doses are used in clinical treatment. The aim of this work is to compare results of palliative high dose rate brachytherapy using various treatment protocols with the view to analysing differences in survival and diminishing breathing difficulties.Material and methodsBetween May 1999 and February 2000 at the Greatpoland Cancer Center, 69 patients with advanced lung cancer were treated by high dose rate brachytherapy. They were disqualified from radical treatment due to advanced clinical stage. The age of the patients ranged from 39 to 76 years (average 53,2 years). Fifty-one patients received a total dose of 22,5 Gy in 3 fractions once a week, 18 patients received one single fraction of 10 Gy. All the patients were divided into two groups according to their clinical stage and the Karnofsky score – those with the Karnofsky score lower than 50 were qualified for a single fraction treatment. They were under clinical and endobronchial observation as regards survival rates, local remission and subsiding dyspnoea, breathing, cough and haemoptysis in the first, third, sixth and twelveth month of observation.ResultsFour weeks after the end of treatment subjective improvement (subsidence of all symptoms) was ascertained in 61/69 (88,4%) patients. In 12 cases (17,4%) complete remission (CR), in 49 cases (71,0%) – partial remission (PR) of the tumor were found. During one year of observation 45 (65,2%) patients died, in 10 cases (14,5%) improvement of in dyspnoea was observed and in 14 cases (20,3%) recurrence and progression of the disease were noted. There was no statistical difference in the survival rates between the two groups of patients treated with different fractions protocols.Conclusions1.Brachytherapy in advanced lung cancer is an efficient method that led in most of patients to subcidence of symptoms and to improvement of the quality their lives.2.The two treatment protocols showed similar efficiency in overcoming difficulties in breathing.3.Survival rates were similar in both group of patients treated with different treatment protocols

Remote Sensing Using Unmanned Aerial Vehicles for Tourist-Recreation Lake Evaluation and Development

This article concerns the use of remote sensing methods to assess the potential of tourism and recreation of lakes by using unmanned aerial vehicles as a tool that offers new measurement possibilities in such difficult areas to research as river and lake systems. For the purpose of the study, air surveys over three lakes used for tourism and recreation purposes were planned and carried out. These were the following lakes: Swarzędzkie, Wolsztyńskie and Zbąszyńskie located in western Poland. The photos were taken with a RGB and a multispectral cameras. On the basis of calculated orthophotomaps and digital surface models, anthropogenic and natural values were assessed. The examples of the research show the versatile possibilities of using drones dependent on the type sensor used. Remote sensing performed from the deck of an unmanned aircraft is widely used in the study of lakes and is an alternative to existing land and water research methods

Remote sensing using unmanned aerial vehicles for tourist-recreation lake evaluation and development

This article concerns the use of remote sensing methods to assess the potential of tourism and recreation of lakes by using unmanned aerial vehicles as a tool that offers new measurement possibilities in such difficult areas to research as river and lake systems. For the purpose of the study, air surveys over three lakes used for tourism and recreation purposes were planned and carried out. These were the following lakes: Swarzędzkie, Wolsztyńskie and Zbąszyńskie located in western Poland. The photos were taken with a RGB and a multispectral cameras. On the basis of calculated orthophotomaps and digital surface models, anthropogenic and natural values were assessed. The examples of the research show the versatile possibilities of using drones dependent on the type sensor used. Remote sensing performed from the deck of an unmanned aircraft is widely used in the study of lakes and is an alternative to existing land and water research methods

The Effect of CacyBP/SIP on the Phosphorylation of ERK1/2 and p38 Kinases in Clear Cell Renal Cell Carcinoma

The prognosis for patients with RCC is very poor because this cancer is diagnosed mainly in the metastatic stage and is resistant to radio- and chemotherapy. According to recent research, CacyBP/SIP exhibits phosphatase activity against MAPK and may be involved in many cellular processes. This function has not been studied in RCC so far, so we decided to test whether CacyBP/SIP has phosphatase function against ERK1/2 and p38 in high-grade clear cell RCC. The research material consisted of fragments of clear cell RCC, whereas the comparative material consisted of the adjacent normal tissues. Immunohistochemistry and qRT-PCR were used to identify the expression of CacyBP/SIP, ERK1/2, and p38. The studies showed an increase in immunoreactivity and gene expression of the parameters examined in clear cell RCC compared with normal tissues. Only in the case of ERK1/2 was it shown that the expression of the MAPK3 gene was downregulated and the MAPK1 gene was higher in clear cell RCC. These studies demonstrated that CacyBP/SIP lacked phosphatase function against ERK1/2 and p38 in high-grade clear cell RCC. Further research is needed because a better understanding of the role of CacyBP/SIP and MAPK offers hope for the treatment of urological cancer

Experience Gained When Using the Yuneec E10T Thermal Camera in Environmental Research

Thermal imaging is an important source of information for geographic information systems (GIS) in various aspects of environmental research. This work contains a variety of experiences related to the use of the Yuneec E10T thermal imaging camera with a 320 × 240 pixel matrix and 4.3 mm focal length dedicated to working with the Yuneec H520 UAV in obtaining data on the natural environment. Unfortunately, as a commercial product, the camera is available without radiometric characteristics. Using the heated bed of the Omni3d Factory 1.0 printer, radiometric calibration was performed in the range of 18–100 °C (high sensitivity range–high gain settings of the camera). The stability of the thermal camera operation was assessed using several sets of a large number of photos, acquired over three areas in the form of aerial blocks composed of parallel rows with a specific sidelap and longitudinal coverage. For these image sets, statistical parameters of thermal images such as the mean, minimum and maximum were calculated and then analyzed according to the order of registration. Analysis of photos taken every 10 m in vertical profiles up to 120 m above ground level (AGL) were also performed to show the changes in image temperature established within the reference surface. Using the established radiometric calibration, it was found that the camera maintains linearity between the observed temperature and the measured brightness temperature in the form of a digital number (DN). It was also found that the camera is sometimes unstable after being turned on, which indicates the necessity of adjusting the device’s operating conditions to external conditions for several minutes or taking photos over an area larger than the region of interest