Cancer mortality in the United Kingdom: projections to the year 2025

The purpose of this study was to project mortality rates in the United Kingdom for the period 2006–2025 for 21 major cancers on the basis of the observed trends in mortality rates during 1971–2005, and to estimate the implication in terms of expected deaths. Age-period-cohort models were applied to official statistics. The projected decrease in age-standardised mortality rates for all cancers from 2003 to 2023 was 17% in men and 16% in women. Future mortality rates were projected to decline for most cancer sites. In men, there were small projected increases in mortality rates from cancers of the oral cavity, oesophagus and melanoma, with a larger projected increase (14% over 20 years) in mortality of liver cancer. In women, the only projected increase (18%) was for corpus uteri. The numbers of deaths will increase for most cancers, with a 30% increase in all cancers projected for men and a 12% increase projected for women. Mortality rates from cancer as a whole have been falling in the United Kingdom since 1990, and this decline was projected to continue into the future as well as the declining rates in both sexes for most cancers. Actual numbers of deaths will increase for most cancers

Multimode optomechanical system in the quantum regime

We realise a simple and robust optomechanical system with a multitude of long-lived ($Q>10^7$) mechanical modes in a phononic-bandgap shielded membrane resonator. An optical mode of a compact Fabry-Perot resonator detects these modes' motion with a measurement rate ($96~\mathrm{kHz}$) that exceeds the mechanical decoherence rates already at moderate cryogenic temperatures ($10\,\mathrm{K}$). Reaching this quantum regime entails, i.~a., quantum measurement backaction exceeding thermal forces, and thus detectable optomechanical quantum correlations. In particular, we observe ponderomotive squeezing of the output light mediated by a multitude of mechanical resonator modes, with quantum noise suppression up to -2.4 dB (-3.6 dB if corrected for detection losses) and bandwidths $\lesssim 90\,\mathrm{ kHz}$. The multi-mode nature of the employed membrane and Fabry-Perot resonators lends itself to hybrid entanglement schemes involving multiple electromagnetic, mechanical, and spin degrees of freedom.Comment: 19 pages, 9 figure

Quantitative Relativistic Effects in the Three-Nucleon Problem

The quantitative impact of the requirement of relativistic invariance in the three-nucleon problem is examined within the framework of Poincar\'e invariant quantum mechanics. In the case of the bound state, and for a wide variety of model implementations and reasonable interactions, most of the quantitative effects come from kinematic factors that can easily be incorporated within a non-relativistic momentum-space three-body code.Comment: 15 pages, 15 figure

An analytical treatment of the Clock Paradox in the framework of the Special and General Theories of Relativity

In this paper we treat the so called clock paradox in an analytical way by assuming that a constant and uniform force F of finite magnitude acts continuously on the moving clock along the direction of its motion assumed to be rectilinear. No inertial motion steps are considered. The rest clock is denoted as (1), the to-and-fro moving clock is (2), the inertial frame in which (1) is at rest in its origin and (2) is seen moving is I and, finally, the accelerated frame in which (2) is at rest in its origin and (1) moves forward and backward is A. We deal with the following questions: I) What is the effect of the finite force acting on (2) on the proper time intervals measured by the two clocks when they reunite? Does a differential aging between the two clocks occur, as it happens when inertial motion and infinite values of the accelerating force is considered? The Special Theory of Relativity is used in order to describe the hyperbolic motion of (2) in the frame I II) Is this effect an absolute one, i.e. does the accelerated observer A comoving with (2) obtain the same results as that in I, both qualitatively and quantitatively, as it is expected? We use the General Theory of Relativity in order to answer this question.Comment: LaTex2e, 19 pages, no tables, no figures. Rewritten version, it amends the previous one whose results about the treatment with General Relativity were wrong. References added. Eq. (55) corrected. More refined version. Comments and suggestions are warmly welcom

The effect of geometry on charge confinement in three dimensions

We show that, in contrast to the flat case, the Maxwell theory is not confining in the background of the three dimensional BTZ black-hole (covering space). We also study the effect of the curvature on screening behavior of Maxwell-Chern-Simons model in this space-time.Comment: 8 pages. To be published in Europhysics Letter

The equivalence principle, uniformly accelerated reference frames, and the uniform gravitational field

The relationship between uniformly accelerated reference frames in flat spacetime and the uniform gravitational field is examined in a relativistic context. It is shown that, contrary to previous statements in the pages of this journal, equivalence does not break down in this context. No restrictions to Newtonian approximations or small enclosures are necessary

First Order Relativistic Three-Body Scattering

Relativistic Faddeev equations for three-body scattering at arbitrary energies are formulated in momentum space and in first order in the two-body transition-operator directly solved in terms of momentum vectors without employing a partial wave decomposition. Relativistic invariance is incorporated within the framework of Poincare invariant quantum mechanics, and presented in some detail. Based on a Malfliet-Tjon type interaction, observables for elastic and break-up scattering are calculated up to projectile energies of 1 GeV. The influence of kinematic and dynamic relativistic effects on those observables is systematically studied. Approximations to the two-body interaction embedded in the three-particle space are compared to the exact treatment.Comment: 26 pages, 13 figure

N-terminal and core-domain random mutations in human topoisomerase II α conferring bisdioxopiperazine resistance

AbstractRandom mutagenesis of human topoisomerase II α cDNA followed by functional expression in yeast cells lacking endogenous topoisomerase II activity in the presence of ICRF-187, identified five functional mutations conferring cellular bisdioxopiperazine resistance. The mutations L169F, G551S, P592L, D645N, and T996L confer >37, 37, 18, 14, and 19 fold resistance towards ICRF-187 in a 24 h clonogenic assay, respectively. Purified recombinant L169F protein is highly resistant towards catalytic inhibition by ICRF-187 in vitro while G551S, D645N, and T996L proteins are not. This demonstrates that cellular bisdioxopiperazine resistance can result from at least two classes of mutations in topoisomerase II; one class renders the protein non-responsive to bisdioxopiperazine compounds, while an other class does not appear to affect the catalytic sensitivity towards these drugs. In addition, our results indicate that different protein domains are involved in mediating the effect of bisdioxopiperazine compounds

Conservation laws for vacuum tetrad gravity

Ten conservation laws in useful polynomial form are derived from a Cartan form and Exterior Differential System (EDS) for the tetrad equations of vacuum relativity. The Noether construction of conservation laws for well posed EDS is introduced first, and an illustration given, deriving 15 conservation laws of the free field Maxwell Equations from symmetries of its EDS. The Maxwell EDS and tetrad gravity EDS have parallel structures, with their numbers of dependent variables, numbers of generating 2-forms and generating 3-forms, and Cartan character tables all in the ratio of 1 to 4. They have 10 corresponding symmetries with the same Lorentz algebra, and 10 corresponding conservation laws.Comment: Final version with additional reference