261 research outputs found
One-Day FISH Approach for the High-Speed Determination of HER2 Gene Copy Status in Breast Carcinoma
No Evidence of Human Polyomavirus 9, WU and KI DNA in Kidney and Urinary Bladder Tumour Tissue Samples
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Digital Measurement of Myelofibrosis Associated Platelet Derived Growth Factor Receptor ß (PDGFR ß) Expression in Bone Marrow Biopsies
In daily routine the reticulin silver staining is used on bone marrow biopsy samples as a gold standard for the characterization of myelofibrosis, however this method does not provide information about the prefibrotic stage.Recently a specific immunohistochemical method was introduced which may overcome these weaknesses of reticulin staining. Activated fibroblasts responsible for stromal proliferation are highlighted by increased PDGFR β expression, which can be presented by immunohistochemistry in bone marrow samples. Using this staining the pre-fibrotic stage can become detectable and we have information about the disease activity.During development of new staining method it is important to prove its reliability and usability. In this paper we introduce a digital image processing method to measure paranchymal damage in digitalized histological slides that can aid correct interpretation of the staining.</p
Sustain, Adapt, and Overcome: hypoxia Associated Changes in the Progression of Lymphatic Neoplasia
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Image analysis of platelet derived growth factor receptor-beta (PDGFRβ) expression to determine the grade and dynamics of myelofibrosis in bone marrow biopsy samples
Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia
Platelet-derived growth factor receptor [béta] (PDGFR[béta]) immunohistochemistry highlights activated bone marrow stroma and is potentially predictive for fibrosis progression in prefibrotic myeloproliferative neoplasia
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