A través del objeto : Le Corbusier y las claves de las maquetas Olivetti

El Centro de Cáculo Electrónico Olivetti en Rho (Milán), proyecto llevado a cabo entre 1962 y 1964, ha sido poco estudiado en relación con otros proyectos del arquitecto, a pesar de su envergadura. Sinembargo, existe una gran cantidad de material elaborado para el mismo,compuesto por numerosas maquetas cuyas técnicas de ejecución,materialidad y textura, entre otras características, desvelan el misterio del proyecto Olivetti: una estrategia modular que marca el inicio del proyecto y lo acompaña hasta el final. Gracias a una mirada analíticadel objeto, es posible establecer un diálogo entre el pasado y el presente del proyecto, es decir, entre el proceso proyectual y las claves del mismo, que se encuentran en las maquetas Olivetti.Además, estas maquetas, reflejan, además las intenciones artísticas del arquitecto, que trata al edificio como si se tratara de uno de sus tapices.Lo cual nos permite entender dichas maquetas como parte dela obra plástica de Le Corbusier.The Olivetti Electronic Center (Rho, Milan), that is a project elaborated between 1962 and 1964, has been very little studied in the Le Corbusier’s whole architectural framework. However, during this period, a great deal of materials were created in order to develop this project. Among these materials, we can find several models whose execution techniques, materiality, texture and other features reveal the Olivetti’s project mystery: a modular strategy marks the beginning of the project and remains until the end of it. If we have an analitic glance to the objet itself, it is possible to stablish a conversation between the porject’s past and present, it means, a conversation between the proyectual process and its own keys, that are found in the Olivetti’s models. These models also represent the architect’s artistic intentions by treating the building as one of his tapestries. This fact lets us see these models as a par of Le Corbusier’s plastic framework.Universidad de Sevilla. Grado en Fundamentos de Arquitectur

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective