A Geant4 based engineering tool for Fresnel lenses

Geant4 is a Monte Carlo radiation transport toolkit that is becoming a tool of generalized application in areas such as high-energy physics, nuclear physics, astroparticle physics, or medical physics. Geant4 provides an optical physics process category, allowing the simulation of the production and propagation of light. Its capabilities are well tailored for the simulation of optics systems namely in cosmic-rays experiments based in the detection of Cherenkov and fluorescence light. The use of Geant4 as an engineering tool for the optics design and simulation of Fresnel lens systems is discussed through a specific example.Comment: 4 pages, 6 figures, Proceedings of the 30th ICRC, International Cosmic Ray Conference 2007, M\'erida, M\'exico, 3-11 July 200

The interplay between the electromagnetic and the muonic longitudinal profile at production

The electromagnetic and the muonic longitudinal profile at production enclosure important information about the primary particle and the hadronic interactions that rule the shower development. In fact, these two profiles provide two different insights of the shower: the electromagnetic component gives a measurement of the energy and the strength of the neutral pion channel; while the muonic profile, being intimately related with the charged mesons decays, can be used as a direct probe for the high energy hadronic interactions. In this work we explore the interplay between the electromagnetic and muonic profiles, by analysing their phenomenologic behaviour for different primary masses and energies, zenith angles, and also different high energy hadronic interaction models. We have found that the muonic longitudinal profile at production displays universal features similar to what is known for the electromagnetic one. Moreover, we show that both profiles have new primary mass composition variables which are fairly independent of the high energy hadronic interaction model. Finally we discuss how the information in the electromagnetic and the muonic longitudinal profile can be combined to break the degeneracy between the primary mass composition and the high energy hadronic physics.Comment: 5 pages, to appear in conference proceedings of International Symposium on Very High Energy Cosmic Ray Interactions (ISVHECRI 2012), Berlin, German

Isotope separation with the RICH detector of the AMS Experiment

The Alpha Magnetic Spectrometer (AMS), to be installed on the International Space Station (ISS) in 2008, is a cosmic ray detector with several subsystems, one of which is a proximity focusing Ring Imaging Cherenkov (RICH) detector. This detector will be equipped with a dual radiator (aerogel+NaF), a lateral conical mirror and a detection plane made of 680 photomultipliers and light guides, enabling precise measurements of particle electric charge and velocity. Combining velocity measurements with data on particle rigidity from the AMS Tracker it is possible to obtain a measurement for particle mass, allowing the separation of isotopes. A Monte Carlo simulation of the RICH detector, based on realistic properties measured at ion beam tests, was performed to evaluate isotope separation capabilities. Results for three elements -- H (Z=1), He (Z=2) and Be (Z=4) -- are presented.Comment: 5 pages. Contribution to the Fifth International Workshop on New Worlds in Astroparticle Physics (Faro 2005). Presenter: Rui Pereir

Response to therapy in Richter syndrome: a systematic review with meta-analysis of early clinical trials

Introduction and aimsRichter syndrome (RS) represents the clonal evolution of chronic lymphocytic leukemia with histological transformation into a high-grade B cell lymphoma (diffuse large B cell lymphoma - DLBCL) or Hodgkin lymphoma. Considering that RS is an uncommon condition with poor prognosis, few high-quality evidence is available. To overcome this unmet need, this meta-analysis aimed to pool efficacy of early clinical trials in Richter syndrome (DLBCL subtype).MethodsMEDLINE, Scopus and Web of Science were searched up to May of 2023 to identify clinical trials decoying efficacy. The pooled complete response, objective response and intension-to-treat failure rates were calculated by pharmacological categories (classical chemotherapy, immunochemotherapy, immunotherapy, Bruton-tyrosine kinase inhibitors, targeted approaches, cell-based therapies and combinatorial regimens) using the Der-Simonian and Laird random-effects model. The Freeman-Tukey double arcsine method was used to estimate variance and confidence intervals. Heterogeneity was assessed using the I2 method.ResultsOverall, from 1242 studies identified, 30 were included, pooling data from 509 patients. The higher efficacy rates when, cell-based therapies were excluded, were achieved by immunochemotherapeutic regimens followed by combinatorial regimens, with complete response rates of 21.54% (IC95%14.93-28.87) and 23.77% (IC95% 8.70-42.19), respectively. Bispecific antibodies (alone or coupled with a chemotherapy debulking strategy) overtook Bruton tyrosine kinase inhibitors response rates. The latter, although achieving objective response rates above average, presented scarce complete response rates. Checkpoint inhibitors alone usually do not lead to complete responses, but their effectiveness may improve when combined with other agents, unveiling the importance of immune microenvironmental modulation.ConclusionThis is the first meta-analysis of early clinical trials assessing the impact of different therapeutics in RS. By analyzing the pooled efficacy estimates, our work suggests the role of a tailor-made bridging therapy for young patients with RS eligible for allogeneic hematopoietic stem cell transplantation (alloSCT), formally the only curative strategy

Accessibility of Brazilian state government websites: a quantitative analysis between 1996 and 2007

A utilização da web para a disponibilização de informações e serviços de órgãos governamentais para os cidadãos tem se tornado cada vez mais expressiva. Assim, a garantia de que esses conteúdos e serviços possam ser acessíveis a qualquer cidadão é imprescindível, independentemente de necessidades especiais ou de quaisquer outras barreiras. No Brasil, o Decreto-Lei nº5.296/2004 determinou que todos os órgãos governamentais deveriam adaptar seus sítios na web de acordo com critérios de acessibilidade até dezembro de 2005. Com o objetivo de verificar a evolução da acessibilidade ao longo dos anos e como foi o impacto dessa legislação, este artigo analisa a acessibilidade dos sítios dos governos estaduais brasileiros por meio de amostras coletadas entre 1996 e 2007. Foram efetuadas análises por meio de métricas, obtidas por avaliações com ferramentas automáticas. Os resultados indicam que a legislação teve pouco impacto para a melhoria real da acessibilidade dos sítios no período indicado, com uma melhora somente em 2007. Verifica-se que se faz necessário adotar políticas públicas mais efetivas para que as pessoas com necessidades especiais tenham os seus direitos para acesso a informações e aos serviços públicos na web assegurados mais amplamente.The use of the web to provide government information and services to citizens has become more and more significant. Ensuring that any citizen can access these contents and services is essential, regardless of disabilities or other barriers they may have. In Brazil, Executive Act no. 5.296/2004 ruled that all government agencies should adapt their websites according to accessibility guidelines until December 2005. In order to check the trend of accessibility over the years and the impact of such legislation, this article analyzes the accessibility of the Brazilian state government websites from 1996 to 2007. Analyses were carried out by means of metrics, obtained by evaluations with automatic tools. The results indicate that the legislation has had little impact on the accessibility of the sites, with an improvement in 2007. Thus, it indicates that it is necessary to adopt more effective public policies to guarantee that people with disabilities have insured their rights to access information and public services on the web.CNP