5 research outputs found
Hipertensão Portopulmonar e Gravidez
A gravidade da coexistência de hipertensão pulmonar e gravidez está bem estabelecida. A hipertensão arterial pulmonar constitui condição com elevado risco de morte materna no final da gravidez e pós-parto. Pacientes portadores de hipertensão portal de várias etiologias podem desenvolver hipertensão arterial pulmonar (hipertensão portopulmonar), sendo a maioria dos casos relatados na cirrose hepática, entretanto uns poucos casos foram descritos na hipertensão portal não cirrótica. São apresentados o quadro clínico e anatomopatológico em dois casos de hipertensão portopulmonar e gravidez. Tratava-se de pacientes com 30 e 24 anos de idade, que desenvolveram insuficiência cardíaca direita grave e choque no puerpério imediato, evoluindo rapidamente para o óbito. A necropsia demonstrou em ambos os casos fibrose nos espaços portais, correspondendo ao relatado na hipertensão portal idiopática, além de hipertensão pulmonar classificada como plexogênica
Hypovitaminosis D is associated with visceral adiposity, high levels of low-density lipoprotein and triglycerides in alternating shift workers.
Background: Studies suggest that there is a strong association between
low vitamin D levels and cardiovascular disease (CVD) and its
risk factors (RFs). Hypovitaminosis D (25(OH)D < 30 ng/mL or 75
nmol/L) is a recent public health problem that has reached different
populations. The objective of the study was to investigate whether
hypovitaminosis D is an additional mechanism to explain the disturbances
in the lipid profile as well as the excess of abdominal fat presented
by alternating shift workers of a mining company in the region
of Inconfidentes, Minas Gerais, Brazil.
Methods: A cross-sectional study was conducted in a sample of 391
adult males, aged 20 - 57 years old and working alternating shifts,
who had at least one risk criterion for CVD. Demographic, behavioral,
clinical, and anthropometric and body composition variables
were obtained. A blood sample was drawn for determining 25(OH)
D, parathyroid hormone intact molecule, lipid profile, blood glucose,
insulin, C-reactive protein, and adipokines.
Results: The average age of the 391 study participants was 36.1 ± 7.3
years. The percentage of hypovitaminosis D and dyslipidemia was
73% and 74.2%, respectively. Excess visceral fat was significant in
the hypovitaminosis D group, with an odds ratio (OR) of 2.4 (95%
confidence interval (CI): 1.1 - 5.2). Dyslipidemia showed 25(OH)D
levels significantly lower (OR: 2.7, 95% CI: 1.6 - 4.3) than in individuals
with normal levels of cholesterol and fractions, and triglycerides.
After adjusted the analysis by age and seasonality, the vitamin levels
had a significant inverse association and dose-dependent with lowdensity
lipoprotein (OR: 5.9), triglycerides (OR: 2.3) and visceral fat
area (OR: 2.4).
Conclusion: Hypovitaminosis D and dyslipidemia were found in the
majority of our mining company shift workers. Furthermore, excess
visceral adiposity, hypertriglyceridemia and high low-density lipoprotein
cholesterol levels are strong predictors of hypovitaminosis D