Safety and pharmacokinetics of intravenous zanamivir treatment in hospitalized adults with influenza: an open-label, multicenter, single-arm, phase II study

Intravenous zanamivir is a neuraminidase inhibitor suitable for treatment of hospitalized patients with severe influenza. Patients were treated with intravenous zanamivir 600 mg twice daily, adjusted for renal impairment, for up to 10 days. Primary outcomes included adverse events (AEs), and clinical/laboratory parameters. Pharmacokinetics, viral load, and disease course were also assessed.5.997 JCR (2014) Q1, 18/148 Inmunology, 4/78 Infectious diseases, 14/119 MicrobiologyUE

Reactivity of Tetrabutylammonium Iodide with a Heteronuclear 6Copper(II)–4Na(I) Complex: Selective Recognition of Iodide Ion

A complex of type [Cu6Na4(μ-O)4(NTA)2(bpy)6(H2O)4(NO3)2]·3H2O 1 was allowed to react separately with tetrabutylammonium salts (TBAX), X = F–, Cl–, Br–, I–, AcO–, NO3–, and H2PO4–. The color of complex 1 changed immediately on the addition of TBAI (tetrabutylammonium iodide) only. However, keeping the corresponding solution for 2 months at room temperature, four complexes of compositions [Cu6(μ-OH)4(NTA)2(bpy)6]2I–·5H2O 2, [Cu2(bpy)2(OH)2(I)]2(NO3)2(H2O) 3, [Cu(bpy)2I]I3– 4, and [Cu(bpy)2I]I·TBAI 5 (bpy = 2,2′-bipyridyl, H3NTA = nitrilotriacetic acid) together with some residues of TBAI and complex 1 were isolated in one-pot synthesis. These complexes were characterized using elemental analysis, spectroscopic (IR, UV–vis) and single crystal X-ray diffraction techniques. Colorimetric response of complex 1 with iodide anions was further supported by the changes in its UV–vis spectra recorded in methanol. The results indicated that 1 exhibits a strong affinity for iodide anions

International trade and firm performance: a survey of empirical studies since 2006

The literature on international trade and firm performance grows exponentially. This paper attempts to summarize what we learn from this literature to guide both future empirical and theoretical work in this area, and public debates and policy makers, in an evidence-based way. The focus is on the empirical part of the literature that consists of recently published papers using data for firms from manufacturing or services industries to study the links between international trade (exports and imports) and dimensions of firm performance (productivity, wages, profitability and survival). It discusses recent add-ons to the box of tools for empirical investigation in this field and suggests topics for future research