IN SILICO DOCKING ANALYSIS OF BIOACTIVE COMPOUNDS FROM CALOPHYLLUM INOPHYLLUM L. ETHANOL LEAF EXTRACT AGAINST EGFR PROTEIN

Objective: The objective of this study was to evaluate the effective new phytocomponents from Calophyllum inophyllum ethanol leaf extract against breast cancer target protein of Epidermal Growth Factor Receptor (EGFR) using in silico docking studies.Materials and Methods: The identification of compounds was done by GC-MS analysis. The in silico docking studies were carried out using Discovery Studio 4.0 software.Results: The GC-MS analysis of ethanol leaf extract revealed the presence of eleven compounds. The docking analysis have exhibited moderate to potent inhibition with a range of dock score 3 to 55. 2H-Benzo(cd) pyrene-2,6(1,H)-dione, 3,5,7,10-tetrahydroxy-compound showed the dock score of 55.427.Conclusion: The results revealed out that the compounds present in Calophyllum inophyllum can inhibit the EGFR protein. The plant possesses anticancer potential because of the various bioactive compounds presence which is mainly responsible for anticancer activity.Â

A Study on Consumer Owned Retailing Store Business Model with special reference to Grocery Products in Karaikal Region

Since consumer cooperative stores play important roles in economic development of a country in post independent period. They fulfill the customer’s needs and wants and they can buy the product at affordable price and profit sharing among the members. After GST implementation the low class and middle class families face difficulties in purchasing of goods and services. As a result it will ultimately affect people’s standard of living, purchases and reduce the consumption of goods and services. Recent trends in the retailing industry cooperative stores have a market potential and benefits to its target customers. So customer owned cooperative retailing stores are strategic business models which create values, deliver values to target customers, make the customers satisfied and provide profit sharing with its members